Results 271 to 280 of about 24,434 (294)

Duck plague virus US3 kinase phosphorylates and induces STING degradation to inhibit innate immune responses. [PDF]

Poult Sci
Tian B, Tian Y, Cai D, Cao H, Wu L, Wang M, Yang Q, Wu Y, Jia R, Zhu D, Liu M, Chen S, Zhao X, Zhang S, Huang J, Sun D, Ou X, Wu Z, Cheng A.   +18 more
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Interplay of cGAS with chromatin

Trends in Biochemical Sciences, 2021
Recognition of DNA is an evolutionarily highly conserved mechanism of immunity. In mammals, the cGAS-STING pathway plays a central role in coupling DNA sensing to the execution of innate immune mechanisms, both in contexts of infection as well as in noninfectious settings of cellular stress and injury. The indiscriminate ability of double-stranded DNA (
Wischnewski, Marilena, Ablasser, Andrea
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cGAS–STING signaling

Current Biology, 2022
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING, also known as TMEM173) constitute the major signaling pathway in vertebrates that senses non-self DNA and elicits potent immune responses. At the core of this pathway, cGAS senses double-stranded DNA (dsDNA) and synthesizes cyclic GMP-AMP (cGAMP).
Zhiqi, Sun, Veit, Hornung
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Step on the cGAS! Viral inhibition of cGAS phase separation with cytosolic DNA

Molecular Cell, 2021
Xu et al. (2021) uncover a conserved viral mechanism to subvert the innate immune system whereby herpesvirus tegument proteins suppress cGAS:DNA phase separation.
Shubhanjali Minhas, Alex S. Holehouse
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CS-CGA: Compact and more Secure CGA

2011 17th IEEE International Conference on Networks, 2011
Cryptographically Generated Address (CGA) is one of the most novel security features introduced in IPv6 suite. CGA is designed to prevent addresses theft without relying on trust authority or additional security infrastructures. However, CGA is relatively computationally intensive, and bandwidth consuming.
Feng Cheng, Ahmad Alsadeh, Christoph Meinel   +2 more
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The cGAS–STING pathway and cancer

Nature Cancer, 2022
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway has emerged as a critical innate immune pathway that, following engagement by DNA, promotes distinct immune effector responses that can impact virtually all aspects of tumorigenesis, from malignant cell transformation to metastasis.
Natasha Samson, Andrea Ablasser
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ReGLUation of cGAS

Nature Immunology, 2016
The detection of cytosolic DNA by the sensor cGAS triggers potent antiviral responses. New data now propose that cGAS is regulated on a post-translational level by glutamylation.
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Development of enzyme immunoassay for chromogranin A (CgA) and profiling of plasma CgA concentrations in the cow

Animal Science Journal, 2021
AbstractThe objectives of this study were to establish and characterize a homologous immunoassay for bovine chromogranin A (bCgA) and to profile plasma bCgA concentrations during early pregnancies. We synthesized oligopeptide corresponding to the amino acid sequence 341–355 of bCgA for immunizing rabbits and peptide corresponding to the amino acid ...
Chihiro Saito, Haruka Ido‐Matsumoto, Hiromasa Kumazaki, Tomoaki Kubo, Tomomi Kanazawa, Toru Takahashi   +5 more
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The chromogranin-A (CgA) in prostate cancer

Archives of Gerontology and Geriatrics, 2006
Prostate cancer is one of the most frequent tumors in men. The neuroendocrine differentiation in prostate cancer has become more widely recognized and has attracted considerable attention as a potentially new finding with major diagnostic, prognostic and therapeutic implications. We investigated the role of the serum concentrations of CgA in a group of
RANNO S, MOTTA, Massimo, RAMPELLO E, RISINO C, BENNATI E, MALAGUARNERA, Mariano   +5 more
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