Results 281 to 290 of about 45,269 (354)

PLAGL1 overexpression exacerbates type 1 diabetes by inducing β-cell apoptosis via oxidative stress-dependent dual DNA damage and cGAS/STING pathway activation. [PDF]

J Diabetes Investig
Li C, Qiao L, Ge J, Hu S, Yang H, Hu C, Li T.   +6 more
europepmc   +1 more source

Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity

Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi‐Chun Lin, Songbai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Jonathan S. Serody, Benjamin G. Vincent, Leo Luznik, Ivana Gojo, Joshua F. Zeidner, Rui Su, Jianjun Chen, Ritin Sharma, Patrick Pirrotte, Xiwei Wu, Weidong Hu, Weidong Han, Binghui Shen, Ya‐Huei Kuo, Jie Jin, Amandeep Salhotra, Jeffrey Wang, Guido Marcucci, Yun Luo, Ling Li   +31 more
openalex   +1 more source

New Advances of Degradable Magnesium‐Based Metal Biomaterials in the Field of Orthopedics

Rare Metals, EarlyView.
ABSTRACT Based on their outstanding biomechanical properties and superior osteogenic activity, magnesium (Mg) and its alloys have been extensively investigated for their biocompatibility and therapeutic efficacy in treating fractures and bone defects.
Jia‐Nan Yu, Shao‐Sheng Jia, Rong‐Bang Sun, Tong Zhang, Ling‐Chuang Bai, Di Mei, Shi‐Jie Zhu, Lan Chen, Shao‐Kang Guan   +8 more
wiley   +1 more source

Systemic LINE-1 RNA in Plasma Extracellular Vesicles Drives Neuroinflammation and Cognitive Dysfunction via cGAS-STING Pathway in Aging. [PDF]

Aging Cell
Yu S, Cheng Q, Yu Q, Cui Z, Chen H, Wu S, Jin Y, Wang Y, Li M, Lu Z.   +9 more
europepmc   +1 more source

Gut Microbial Butyrate Boosts P53-Expressing Telomerase-Specific Oncolytic Adenovirus Efficacy by Enhancing Infectivity and Activating Mhc-I and the Cgas-Sting Pathway

Masaki Sakamoto, Shinji Kuroda, Tetsuya Katayama, Yu Mikane, Shunya Hanzawa, Daisuke Kadowaki, Yusuke Yoshida, Yuki Hamada, Ryoma Sugimoto, Chiaki Yagi, Masashi Hashimoto, Nobuhiko Kanaya, Yoshihiko Kakiuchi, Satoru Kikuchi, Kunitoshi Shigeyasu, Hiroshi Tazawa, Shunsuke Kagawa, Yasuo Urata, Toshiyoshi Fujiwara   +18 more
openalex   +1 more source

Large Cell Neuroendocrine Carcinoma of the Cervix With Extensive Metastases

The Kaohsiung Journal of Medical Sciences, EarlyView.
Di‐Ping Yu, Li‐Mei Sun
wiley   +1 more source

Resveratrol attenuates areca nut extract‐induced chronic colitis by suppressing pyroptosis of intestinal epithelial cells via modulating cGAS/STING signaling

VIEW, EarlyView.
Areca nut extract (ANE), commonly consumed in some cultures, can damage gut cells by triggering inflammation and cell death through a pathway called cGAS‐STING. This leads to the release of harmful inflammatory substances and weakens the gut barrier. Our study shows that resveratrol, a natural compound found in foods like grapes, can block this harmful
Jing Zhang, Muhammad Tufail, Yu‐Qi Huang, Can‐Hua Jiang, Ning Li   +4 more
wiley   +1 more source

Restoration of cGAS in cancer cells promotes antitumor immunity via transfer of cancer cell-generated cGAMP. [PDF]

Proc Natl Acad Sci U S A
Cryer AM, Dosta P, Dion MZ, de la Parra Soto L, Amar-Lewis E, Garcia de Leon Carmona G, Espinosa Pérez AA, Fernando Ruiz Aguilar D, Huerta T, Ruiz BN, Casteele Hernandez NN, Soria Y, Artzi N.   +12 more
europepmc   +1 more source

Polystyrene nanoplastics induce pulmonary oxidative stress and programmed cell death through the cGAS-STING-NLRP3 pathway

Y. Wang, Yaoyao Zhang, Mengwei Zhang, Xin Zhou, Linlin You, Jian Gao, Yuying Li   +6 more
openalex   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source