Results 281 to 290 of about 24,434 (294)
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Science, 2021
Innate Immunity Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al.
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Innate Immunity Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al.
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Nature Reviews Rheumatology, 2019
Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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Sensing of cytosolic DNA by cyclic GMP–AMP synthase (cGAS) is central to the pathogenesis of a number of autoinflammatory syndromes and possibly some autoimmune diseases, such as systemic lupus erythematosus (SLE). Activation of cGAS signalling requires its deacetylation, so might aspirin have therapeutic potential to treat SLE by acetylating cGAS?
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2007
Recent advances in genome sequencing technology and algorithms have made it possible to determine the sequence of a whole genome quickly in a cost-effective manner. As a result, there are more than 200 completely sequenced genomes. However, annotation of a genome is still a challenging task.
Kwangmin Choi, Sun Kim, Youngik Yang
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Recent advances in genome sequencing technology and algorithms have made it possible to determine the sequence of a whole genome quickly in a cost-effective manner. As a result, there are more than 200 completely sequenced genomes. However, annotation of a genome is still a challenging task.
Kwangmin Choi, Sun Kim, Youngik Yang
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Loosening the grip on nuclear cGAS
Nature Genetics, 2020Maintaining ignorance to self-nucleic acids can prevent inflammatory diseases such as Aicardi–Goutieres syndrome (AGS). A new study finds that mutations in LSM11 and RNU7-1, which encode components of the histone messenger RNA–preprocessing complex, cause AGS by loosening the binding of cyclic GMP–AMP synthase (cGAS) to nucleosomes, thus enabling cGAS ...
Fiachra Humphries +1 more
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Nature Reviews Molecular Cell Biology, 2018
Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Cyclic GMP–AMP synthase (cGAS) inhibits DNA damage repair in the nucleus and thereby promotes tumorigenesis.
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Modified cGA for electromagnetic optimization
2014 XXXIth URSI General Assembly and Scientific Symposium (URSI GASS), 2014Compact Genetic Algorithm (cGA), which uses a probability vector (PV) to represent the population, has been proposed as an alternative of the simple Genetic algorithm (sGA), which greatly reduces the memory storage requiring during its performance. The cGA, however, just performed equivalently to sGA.
Van Ha, Bui +4 more
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Science Signaling
The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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The DNA double-strand break sensor MRE11 is necessary to liberate cGAS and enable its activation by dsDNA.
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Science-Business eXchange, 2013
University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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University of Texas Southwestern Medical Center researchers have confirmed the role of cyclic GMP-AMP signaling in the innate immune system, making a case for developing adjuvants that agonize the pathway or antagonists of the pathway to treat autoimmune conditions.
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cGAS Conducts Micronuclei DNA Surveillance
Trends in Cell Biology, 2017DNA damage elicits a potent proinflammatory immune response. A collection of four papers now reveals that micronuclear DNA is a new cell intrinsic immunostimulatory molecule, and that accumulation of the immune sensor cyclic GMP-AMP synthase (cGAS) in micronuclei leads to a cell-cycle-dependent proinflammatory response following DNA damage.
Carina C. de Oliveira Mann +1 more
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The role of cGAS in innate immunity and beyond
Journal of Molecular Medicine, 2016The sensing of foreign DNA is crucial for host defense against several pathogens. In the cytosol the enzyme cyclic GMP-AMP synthase (cGAS) is critical for the recognition of pathogen-derived DNA and provides key signals that initiate immune responses. Beyond infection, accumulating evidence indicates that cGAS is also active during autoimmune diseases ...
Muhammed F. Gulen, Andrea Ablasser
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