Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation [PDF]
The Journal of Immunology, 2017 Abstract The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. Upon nonspecific binding of cytosolic B–form DNA, cGAS synthesizes the second messenger 2′3′-cGAMP and triggers STING-dependent signaling to produce type I
Jianli Tao +8 more
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How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response
Frontiers in Immunology, 2021 cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I ...
Yuying Ma +25 more
doaj +1 more source
Sea anemone model has a single Toll-like receptor that can function in pathogen detection, NF-κB signal transduction, and development [PDF]
, 2017 In organisms from insects to vertebrates, Toll-like receptors (TLRs) are primary pathogen detectors that activate downstream pathways, specifically those that direct expression of innate immune effector genes.
Brennan, Joseph J. +5 more
core +1 more source
, 2020 Multitasking optimization is a recently introduced paradigm, focused on the simultaneous solving of multiple optimization problem instances (tasks). The goal of multitasking environments is to dynamically exploit existing complementarities and synergies ...
Del Ser, Javier +4 more
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Beyond self-eating: The control of nonautophagic functions and signaling pathways by autophagy-related proteins. [PDF]
, 2017 The identification of conserved autophagy-related proteins (ATGs) that mediate bulk degradation of cytosolic material laid the foundation for breakthroughs linking autophagy to a litany of physiological processes and disease conditions.
Cadwell, Ken, Debnath, Jayanta
core +1 more source
The multifaceted functions of cGAS
Journal of Molecular Cell Biology, 2022 Abstract Pattern recognition receptors are critical for the sensing of pathogen-associated molecular patterns or danger-associated molecular patterns and subsequent mounting of innate immunity and shaping of adaptive immunity. The identification of 2′3′-cyclic guanosine monophosphate–adenosine monophosphate (cGAMP) synthase (cGAS) as a ...
Liu, Haipeng +4 more
openaire +2 more sources
cGAS-STING signalings potentiate tumor progression via sustaining cancer stemness
Translational Oncology, 2022 The cytosolic DNA-sensing cGAS-STING pathway has been proved to be involved in tumor progression and influence the effect of cancer immunotherapy. However, little attentions have been paid to the role of cGAS-STING pathway on cancer stemness.
Fu-rao Liu +4 more
doaj +1 more source
Treatment decision-making capacity in children and adolescents hospitalized for an acute mental disorder: The role of cognitive functioning and psychiatric symptoms [PDF]
, 2017 OBJECTIVE: This study was conducted to assess treatment decision-making capacity (TDMC) in a child and adolescent psychiatric sample and to verify possible associations between TDMC, psychiatric symptom severity, and cognitive functioning.
Ferracuti, Stefano +5 more
core +1 more source
A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence [PDF]
, 2017 OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood.
Asarnow, Joan R. +3 more
core +1 more source