Results 21 to 30 of about 43,268 (339)
cGAS is essential for cellular senescence [PDF]
Proceedings of the National Academy of Sciences, 2017 Significance Cellular senescence is important for the maintenance of tissue homeostasis. Dysregulation of senescence is linked to many human diseases, such as cancer, premature aging, and age-related diseases. Although DNA damage response has been linked to senescence, the underlying mechanism is unknown.
Hui Yang +4 more
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Nature Communications, 2023 The immunologically “cold” microenvironment of triple negative breast cancer results in resistance to current immunotherapy. Here, we reveal the immunoadjuvant property of gas therapy with cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS ...
Kaiyuan Wang +13 more
semanticscholar +1 more source
Ubiquitin-like conjugation by bacterial cGAS enhances anti-phage defence
Nature, 2023 Cap2 of the cyclic dinucleotide-based anti-phage immune system functions through a ubiquitin-like conjugation mechanism to regulate cGAS activity. cGAS is an evolutionarily conserved enzyme that has a pivotal role in immune defence against infection^ 1 –
J. Jenson +4 more
semanticscholar +1 more source
The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
Nature, 2022 COVID-19, which is caused by infection with SARS-CoV-2, is characterized by lung pathology and extrapulmonary complications 1 , 2 . Type I interferons (IFNs) have an essential role in the pathogenesis of COVID-19 (refs 3 – 5 ).
J. Di Domizio +16 more
semanticscholar +1 more source
Critical Role of the cGAS-STING Pathway in Doxorubicin-Induced Cardiotoxicity
Circulation Research, 2023 Background: Doxorubicin is an effective chemotherapy drug for treating various types of cancer. However, lethal cardiotoxicity severely limits its clinical use.
Weihua Luo +22 more
semanticscholar +1 more source
The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis [PDF]
Signal Transduction and Targeted Therapy, 2021 Psychosocial stress is one of the main environmental factors contributing to the development of psychiatric disorders. In humans and rodents, chronic stress is associated with elevated inflammatory responses, indicated by increased numbers of circulating myeloid cells and activation of microglia, the brain-resident immune cells.
Eva Bartok +3 more
openaire +5 more sources
Mechanism and therapeutic potential of targeting cGAS-STING signaling in neurological disorders
Molecular Neurodegeneration, 2023 DNA sensing is a pivotal component of the innate immune system that is responsible for detecting mislocalized DNA and triggering downstream inflammatory pathways.
Yige Huang +4 more
semanticscholar +1 more source
Nonspecific DNA Binding of cGAS N Terminus Promotes cGAS Activation [PDF]
The Journal of Immunology, 2017 Abstract The cytosolic DNA sensor cyclic GMP-AMP synthase (cGAS) mediates innate immune responses against invading pathogens, or against self-dsDNA, which causes autoimmune disorders. Upon nonspecific binding of cytosolic B–form DNA, cGAS synthesizes the second messenger 2′3′-cGAMP and triggers STING-dependent signaling to produce type I
Jianli Tao +8 more
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Zoological Research, 2023 The innate immune system protects the host from external pathogens and internal damage in various ways. The cGAS-STING signaling pathway, comprised of cyclic GMP-AMP synthase (cGAS), stimulator of interferon genes (STING), and downstream signaling ...
Jing Pan +5 more
semanticscholar +1 more source
Mn-based cGAS-STING activation for tumor therapy.
Chinese journal of cancer research = Chung-kuo yen cheng yen chiu, 2023 Immunotherapy has efficiently revolutionized the treatment of human neoplastic diseases. However, the overall responsive rate of current immunotherapy is still unsatisfactory, benefiting only a small proportion of patients.
Aiping Huang, Wenhao Zhou
semanticscholar +1 more source