Results 31 to 40 of about 45,269 (354)

Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs

Frontiers in Immunology, 2023
Cyclic GMP-AMP Synthase (cGAS) is a pivotal adaptor of the signaling pathways involving the pattern recognition receptors and plays an important role in apoptosis and immune regulation.
Chang Lin, Chang Lin, Min Zheng, Shifeng Xiao, Shao Wang, Xiaoli Zhu, Xiuqin Chen, Dandan Jiang, Xiancheng Zeng, Shaoying Chen, Shilong Chen, Shilong Chen   +11 more
doaj   +1 more source

Clumping factors of HII, HeII and HeIII

, 2014
Estimating the intergalactic medium ionization level of a region needs proper treatment of the reionization process for a large representative volume of the universe.
Ciardi, Benedetta, Graziani, Luca, Jeeson-Daniel, Akila   +2 more
core   +1 more source

Nuclear cGAS restricts L1 retrotransposition by promoting TRIM41-mediated ORF2p ubiquitination and degradation

Nature Communications, 2023
Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor, detects DNA fragments to trigger an innate immune response. Recently, accumulating evidence reveals the presence of cGAS within the nucleus. However, the biological functions
Zhengyi Zhen, Yu Chen, Haiyan Wang, Huanyin Tang, Haiping Zhang, Haipeng Liu, Ying Jiang, Zhiyong Mao   +7 more
doaj   +1 more source

Anisotropic selection in cellular genetic algorithms [PDF]

, 2006
In this paper we introduce a new selection scheme in cellular genetic algorithms (cGAs). Anisotropic Selection (AS) promotes diversity and allows accurate control of the selective pressure.
Clergue, Manuel, Collard, Philippe, Simoncini, David, Verel, Sébastien   +3 more
core   +3 more sources

Activation of the cGAS-STING pathway by clofoctol through mitochondrial damage in triple-negative breast cancer. [PDF]

J Transl Med
Wang L, Zheng L, Yong X, Ding Z, Sun J, Tang Y, Tang K, Li Y, Chen J, Qi S, Hu H, Tang H.   +11 more
europepmc   +3 more sources

cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy

Frontiers in Bioscience-Landmark
Background: Radiotherapy is a commonly employed treatment modality for cancer; however, its radiobiological effects in hypertrophic cardiomyopathy (HCM) remain unclear.
Huiyang Li, Xin Wang, Xinping Luo, Haiming Shi, Jian Li   +4 more
doaj   +1 more source

Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients

OncoImmunology, 2019
CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with ...
Eric C. Ko, Lorenzo Galluzzi
doaj   +1 more source

Natural Compounds as Beneficial Antioxidant Agents in Neurodegenerative Disorders: A Focus on Alzheimer’s Disease [PDF]

, 2019
The positive role of nutrition in chronic neurodegenerative diseases (NDs) suggests that dietary interventions represent helpful tools for preventing NDs.
Antonella Amato, Flavia Mulè, Simona Terzo   +2 more
core   +1 more source

Barrier-to-autointegration factor 1 protects against a basal cGAS-STING response [PDF]

, 2020
Although the pathogen recognition receptor pathways that activate cell-intrinsic antiviral responses are well delineated, less is known about how the host regulates this response to prevent sustained signaling and possible immune-mediated damage. Using a
Artyomov, Maxim, Bambouskova, Monika, Byrum, Andrea K, Collins, Patrick L, Diamond, Michael S, Ma, Hongming, Miner, Jonathan J, Mosammaparast, Nima, Oltz, Eugene M, Porter, Sofia I, Qian, Wei, Zhang, Rong   +11 more
core   +2 more sources

cGAS Micro-Manages Genotoxic Stress [PDF]

Immunity, 2017
Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA sensor cGAS gains access to the cargo within micronuclei to drive type I IFN responses.
Mona, Motwani, Katherine A, Fitzgerald
openaire   +2 more sources