Results 31 to 40 of about 31,976 (243)

Gender and Development: An Evaluation of World Bank Support, 2002-08 [PDF]

open access: yes, 2010
This evaluation reviews the World Bank's progress in gender integration from 2002 through 2008. Implementation of a 2001 gender strategy was initially strong, with integration into relevant projects peaking at 64% in 2003; but it declined between 2006 ...

core  

Centrally Extended Conformal Galilei Algebras and Invariant Nonlinear PDEs

open access: yes, 2015
We construct, for any given $ \ell = \frac{1}{2} + {\mathbb N}_0, $ the second-order \textit{nonlinear} partial differential equations (PDEs) which are invariant under the transformations generated by the centrally extended conformal Galilei algebras ...
Aizawa, Naruhiko, Kato, Tadanori
core   +2 more sources

Anisotropic selection in cellular genetic algorithms [PDF]

open access: yes, 2006
In this paper we introduce a new selection scheme in cellular genetic algorithms (cGAs). Anisotropic Selection (AS) promotes diversity and allows accurate control of the selective pressure.
Clergue, Manuel   +3 more
core   +3 more sources

cGAS Dimerization Entangles DNA Recognition [PDF]

open access: yesImmunity, 2013
Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of Immunity, Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-induced dimerization.
Philip J. Kranzusch, Russell E. Vance
openaire   +3 more sources

Spin‐Selective Anisotropic Magnetoresistance Driven by Chirality in DNA

open access: yesAdvanced Functional Materials, EarlyView.
It is shown that magnetoresistance (MR) measurements carried out as a function of angular dependence between the magnetic field and a chiral (DNA) interface provide a valuable new insight into the charge transport mechanism associated with the chiral‐induced spin selectivity (CISS) effect.
Tapan Kumar Das   +4 more
wiley   +1 more source

Neuroinflammation and the cGAS-STING pathway [PDF]

open access: yesJournal of Neurophysiology, 2019
The recent discovery of cyclic GMP-AMP synthase (cGAS) as the mammalian cytosolic DNA sensor has profound therapeutic implications for infection, immunology, and cancer. Because neurovirology, neuroimmunology, neuro-oncology, and neurodegeneration implicate cytosolic DNA sensing, cGAS activation and induction of the downstream signaling protein ...
openaire   +3 more sources

CGAS: comparative genomic analysis server [PDF]

open access: yesBioinformatics, 2009
Abstract Summary: Comparative approach is one of the most essential methods for extracting functional and evolutionary information from genomic sequences. So far, a number of sequence comparison tools have been developed, and most are either for on-site use, requiring program installation but providing a wide variety of analyses, or for ...
Hidemi Watanabe, Masumi Itoh
openaire   +2 more sources

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

open access: yesAdvanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim   +8 more
wiley   +1 more source

A Visible Light‐Responsive Hydrogel to Study the Effect of Dynamic Tissue Stiffness on Cellular Mechanosensing

open access: yesAdvanced Functional Materials, EarlyView.
A visible light‐responsive polyacrylamide‐azobenzene hydrogel enables safe, reversible stiffness control for studying cell mechanobiology without harmful UV exposure. This approach reveals stem cells respond rapidly to mechanical changes, showing altered shape and protein distribution within one hour.
Aafreen Ansari   +11 more
wiley   +1 more source

A randomized clinical trial comparing family-focused treatment and individual supportive therapy for depression in childhood and early adolescence [PDF]

open access: yes, 2017
OBJECTIVE: Despite the morbidity and negative outcomes associated with early-onset depression, few studies have examined the efficacy of psychosocial treatment for depressive disorders during childhood.
Asarnow, Joan R.   +3 more
core   +1 more source

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