Results 31 to 40 of about 43,268 (339)
PRMT1 mediated methylation of cGAS suppresses anti-tumor immunity
Nature Communications, 2023 Activation of the cGAS/STING innate immunity pathway is essential and effective for anti-tumor immunotherapy. However, it remains largely elusive how tumor-intrinsic cGAS signaling is suppressed to facilitate tumorigenesis by escaping immune surveillance.
Jing Liu +7 more
semanticscholar +1 more source
How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis
International Journal of Molecular Sciences, 2023 The cGAS–STING signaling axis can be activated by cytosolic DNA, including both non-self DNA and self DNA. This axis is used by the innate immune system to monitor invading pathogens and/or damage.
Wanglong Zheng +5 more
semanticscholar +1 more source
Significance of the cGAS-STING Pathway in Health and Disease
International Journal of Molecular Sciences, 2023 The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway plays a significant role in health and disease. In this pathway, cGAS, one of the major cytosolic DNA sensors in mammalian cells, regulates innate immunity and the STING ...
Jinglin Zhou +3 more
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2021 Significance Impaired neuronal bioenergetics and neuroinflammation are thought to play key roles in the progression of Alzheimer's disease (AD), but their interplay is not clear.
Yujun Hou +8 more
semanticscholar +1 more source
Experimental and Molecular Medicine, 2022 Low back pain (LBP) is a major musculoskeletal disorder and the socioeconomic problem with a high prevalence that mainly involves intervertebral disc (IVD) degeneration, characterized by progressive nucleus pulposus (NP) cell death and the development of
Weifeng Zhang +16 more
semanticscholar +1 more source
PLoS Pathogens, 2023 Cyclic GMP-AMP synthase (cGAS) plays a key role in the innate immune responses to both DNA and RNA virus infection. Here, we found that enterovirus 71 (EV-A71), Seneca Valley virus (SVV), and foot-and-mouth disease virus (FMDV) infection triggered ...
Huisheng Liu +12 more
semanticscholar +1 more source
Length does matter for
EMBO reports, 2017 Recognition of foreign nucleic acids by the immune system is essential to host protection against many viral and bacterial infections. It relies on the capacity of innate immune sensors to selectively distinguish self‐ and non‐self‐nucleic acids, on the basis of a variety of parameters including base modifications, sequence composition, length or ...
Michael P. Gantier
openalex +4 more sources
Pharmacological Activation of cGAS for Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2021 When compartmentally mislocalized within cells, nucleic acids can be exceptionally immunostimulatory and can even trigger the immune-mediated elimination of cancer. Specifically, the accumulation of double-stranded DNA in the cytosol can efficiently promote antitumor immunity by activating the cGAMP synthase (cGAS) / stimulator of interferon genes ...
Kyle M. Garland +15 more
openaire +4 more sources
Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response
Frontiers in Immunology, 2021 cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I ...
Yuying Ma +25 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2023 Currently, the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide. COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon (IFN-I) signal, along with limited activation of antiviral immune responses as ...
Sihui Cai +14 more
semanticscholar +1 more source