Results 41 to 50 of about 57,474 (382)
Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion [PDF]
, 2017 Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis.
Adolfo García-Sastre +13 more
core +3 more sources
PLoS Pathogens, 2023 Cyclic GMP-AMP synthase (cGAS) plays a key role in the innate immune responses to both DNA and RNA virus infection. Here, we found that enterovirus 71 (EV-A71), Seneca Valley virus (SVV), and foot-and-mouth disease virus (FMDV) infection triggered ...
Huisheng Liu +12 more
semanticscholar +1 more source
Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs
Frontiers in Immunology, 2023 Cyclic GMP-AMP Synthase (cGAS) is a pivotal adaptor of the signaling pathways involving the pattern recognition receptors and plays an important role in apoptosis and immune regulation.
Chang Lin +11 more
doaj +1 more source
Using stepped-care approaches within internet-based interventions for youth anxiety: Three case studies. [PDF]
, 2019 Background There are a lack of clear guidelines for the dissemination of Internet-based cognitive behaviour therapy (ICBT) for childhood and adolescent anxiety in routine care.
Baldwin, Sarah +4 more
core +2 more sources
Pharmacological Activation of cGAS for Cancer Immunotherapy [PDF]
Frontiers in Immunology, 2021 When compartmentally mislocalized within cells, nucleic acids can be exceptionally immunostimulatory and can even trigger the immune-mediated elimination of cancer. Specifically, the accumulation of double-stranded DNA in the cytosol can efficiently promote antitumor immunity by activating the cGAMP synthase (cGAS) / stimulator of interferon genes ...
Kyle M. Garland +15 more
openaire +4 more sources
Trial watch: STING agonists in cancer therapy
OncoImmunology, 2020 Stimulator of interferon response cGAMP interactor 1 (STING1, best known as STING) is an endoplasmic reticulum-sessile protein that serves as a signaling hub, receiving input from several pattern recognition receptors, most of which sense ectopic DNA ...
Julie Le Naour +4 more
doaj +1 more source
Signal Transduction and Targeted Therapy, 2023 Currently, the incidence and fatality rate of SARS-CoV-2 remain continually high worldwide. COVID-19 patients infected with SARS-CoV-2 exhibited decreased type I interferon (IFN-I) signal, along with limited activation of antiviral immune responses as ...
Sihui Cai +14 more
semanticscholar +1 more source
Length does matter for
EMBO reports, 2017 Recognition of foreign nucleic acids by the immune system is essential to host protection against many viral and bacterial infections. It relies on the capacity of innate immune sensors to selectively distinguish self‐ and non‐self‐nucleic acids, on the basis of a variety of parameters including base modifications, sequence composition, length or ...
Michael P. Gantier
openalex +4 more sources
Roles of Emerging RNA-Binding Activity of cGAS in Innate Antiviral Response
Frontiers in Immunology, 2021 cGAS, a DNA sensor in mammalian cells, catalyzes the generation of 2’-3’-cyclic AMP-GMP (cGAMP) once activated by the binding of free DNA. cGAMP can bind to STING, activating downstream TBK1-IRF-3 signaling to initiate the expression of type I ...
Yuying Ma +25 more
doaj +1 more source
cGAS surveillance of micronuclei links genome instability to innate immunity
Nature, 2017 DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage.
Karen J. Mackenzie +16 more
openalex +3 more sources