Results 41 to 50 of about 41,079 (213)
SnapShot: CGAS-STING Signaling
Cell, 2018 CGAS responds to cytosolic DNA by initiating a STING-dependent response that ultimately engages innate immune effectors to ensure the preservation of organismal homeostasis.
Lorenzo, Galluzzi +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Gender and Development: An Evaluation of World Bank Support, 2002-08 [PDF]
, 2010 This evaluation reviews the World Bank's progress in gender integration from 2002 through 2008. Implementation of a 2001 gender strategy was initially strong, with integration into relevant projects peaking at 64% in 2003; but it declined between 2006 ...
core
Type I interferons in tuberculosis: Foe and occasionally friend [PDF]
, 2018 Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K +3 more
core +1 more source
Aging and Cancer, EarlyView.Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath +3 more
wiley +1 more source
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy
Frontiers in Bioscience-LandmarkBackground: Radiotherapy is a commonly employed treatment modality for cancer; however, its radiobiological effects in hypertrophic cardiomyopathy (HCM) remain unclear.
Huiyang Li +4 more
doaj +1 more source
Apoptotic caspases cut down the immunogenicity of radiation
OncoImmunology, 2019 Caspases are known for their ability to precipitate apoptosis. Our findings indicate that accelerating the terminal inactivation of cells dying in response to radiation therapy limit their immunogenicity as a consequence of reduced type I interferon ...
Aitziber Buqué +3 more
doaj +1 more source
Prevailing dust-transport directions on comet 67P/Churyumov-Gerasimenko
, 2015 Dust transport and deposition behind larger boulders on the comet 67P/Churyumov-Gerasimenko (67P/C-G) have been observed by the Rosetta mission. We present a mechanism for dust transport vectors based on a homogenous surface activity model incorporating ...
Kramer, Tobias, Noack, Matthias
core +1 more source
The polyphenolic and hydroxycinnamate contents of whole coffee fruits from China, India and Mexico [PDF]
, 2013 Air dried whole coffee fruits, beans and husks from China, India and Mexico were analysed for their chlorogenic acids (CGA), caffeine, and polyphenolic content. Analysis was by HPLC and Orbitrap exact mass spectrometry.
Combet, E. +4 more
core +1 more source
Advanced Functional Materials, EarlyView.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source