Results 41 to 50 of about 43,268 (339)
Cyclic GMP–AMP synthase (cGAS), initially identified as a cytosolic DNA sensor, detects DNA fragments to trigger an innate immune response. Recently, accumulating evidence reveals the presence of cGAS within the nucleus. However, the biological functions
Zhengyi Zhen+7 more
doaj +1 more source
The cGAS-STING pathway in atherosclerosis. [PDF]
Atherosclerosis (AS), a chronic inflammatory disease, remains a leading contributor to cardiovascular morbidity and mortality. Recent studies highlight the critical role of the cGAS-STING pathway—a key innate immune signaling cascade—in driving AS progression.
Wang SY, Chen YS, Jin BY, Bilal A.
europepmc +4 more sources
cGAS surveillance of micronuclei links genome instability to innate immunity
DNA is strictly compartmentalized within the nucleus to prevent autoimmunity; despite this, cyclic GMP–AMP synthase (cGAS), a cytosolic sensor of double-stranded DNA, is activated in autoinflammatory disorders and by DNA damage.
Karen J. Mackenzie+16 more
openalex +3 more sources
Antecedent chromatin organization determines cGAS recruitment to ruptured micronuclei
Micronuclei (MN) are cytosolic bodies that sequester acentric fragments or mis-segregated chromosomes from the primary nucleus. Spontaneous rupture of the MN envelope allows recognition by the viral receptor cyclic GMP-AMP synthase (cGAS), initiating ...
Kate M. MacDonald+5 more
semanticscholar +1 more source
CGAS is a micronucleophagy receptor for the clearance of micronuclei [PDF]
Micronuclei are constantly considered as a marker of genome instability and very recently found to be a trigger of innate immune responses. An increased frequency of micronuclei is associated with many diseases, but the mechanism underlying the regulation of micronuclei homeostasis remains largely unknown.
Mengmeng Zhao+10 more
openaire +2 more sources
Duck cGAS inhibits DNA and RNA virus replication by activating IFNs and antiviral ISGs
Cyclic GMP-AMP Synthase (cGAS) is a pivotal adaptor of the signaling pathways involving the pattern recognition receptors and plays an important role in apoptosis and immune regulation.
Chang Lin+11 more
doaj +1 more source
cGAS‐STING signaling in cell death: Mechanisms of action and implications in pathologies
Cyclic GMP‐AMP synthase (cGAS) monitors dsDNA in the cytosol in response to pathogenic invasion or tissue injury, initiating cGAS‐STING signaling cascades that regulate various cellular physiologies, including IFN /cytokine production, autophagy, protein
Yifan Xu+3 more
semanticscholar +1 more source
Function and regulation of cGAS-STING signaling in infectious diseases
The efficacious detection of pathogens and prompt induction of innate immune signaling serve as a crucial component of immune defense against infectious pathogens.
Yang Du+5 more
semanticscholar +1 more source
cGAS/STING/NLRP3 Signaling Pathway-Mediated Pyroptosis in Hypertrophic Cardiomyopathy Radiotherapy
Background: Radiotherapy is a commonly employed treatment modality for cancer; however, its radiobiological effects in hypertrophic cardiomyopathy (HCM) remain unclear.
Huiyang Li+4 more
doaj +1 more source
Radiation unlocks the therapeutic potential of immune checkpoint blockers in lung cancer patients
CTLA4 blockers have limited activity in patients with chemorefractory lung cancer. Recent clinical data demonstrate that radiation therapy combined with CTLA4 blockers enables disease control in a sizeable fraction of these patients, correlating with ...
Eric C. Ko, Lorenzo Galluzzi
doaj +1 more source