Results 51 to 60 of about 45,269 (354)

Gender and Development: An Evaluation of World Bank Support, 2002-08 [PDF]

, 2010
This evaluation reviews the World Bank's progress in gender integration from 2002 through 2008. Implementation of a 2001 gender strategy was initially strong, with integration into relevant projects peaking at 64% in 2003; but it declined between 2006 ...

core  

A Multiphase Model for the Intracluster Medium [PDF]

, 1999
Constraints on the clustered mass density \Omega_m of the universe derived from the mean intracluster gas fraction of X-ray clusters may be biased by a single-phase assumption for the thermodynamic structure of the intracluster medium (ICM). We propose a
A. E. Evrard, Birkinshaw M., Cavaliere A., Cen R., Cole S., D. Nagai, David L. P., Eke V. R., Fabian A. C., Frenk C. S., Gunn K. F., Hamuy M., Inagaki Y., Irwin J. A., Irwin J. A., Jones M., M. E. Sulkanen, Mohr J. J., Navarro J. F., Neumann D. M., Nulsen P. E. J., Peres C. B., Raymond J. C., Riess A. G., Thomas P., Thomas P. A., White D. A., White S. D. M., Zaroubi S.   +28 more
core   +3 more sources

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

Prevailing dust-transport directions on comet 67P/Churyumov-Gerasimenko

, 2015
Dust transport and deposition behind larger boulders on the comet 67P/Churyumov-Gerasimenko (67P/C-G) have been observed by the Rosetta mission. We present a mechanism for dust transport vectors based on a homogenous surface activity model incorporating ...
Kramer, Tobias, Noack, Matthias
core   +1 more source

Enhancing Oncological Care for India's Aging Population: Addressing the Complex Needs of Older Adults With Cancer

Aging and Cancer, EarlyView.
Aging‐associated physiological and molecular alterations pose significant challenges in cancer management among India's elderly. Limited geriatric oncology expertise, financial constraints, and inadequate specialized care exacerbate disparities. Strategic expansion of insurance coverage, integration of palliative care, and infrastructural advancements ...
Nihanthy D. Sreenath, Mathigatta Shivarudraiah S, Rajath Govind, Kaushik M R   +3 more
wiley   +1 more source

The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

Medical Review
As a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2′3′ cyclic GMP-AMP (cGAMP) that activates the stimulator of interferon genes (STING).
Zhou Zheqi, Huang Sanling, Fan Fangying, Xu Yan, Moore Casey, Li Sirui, Han Chuanhui   +6 more
doaj   +1 more source

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Mediators of Inflammation, 2015
Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation.
Yan Wang, Guo-Hua Su, Fang Zhang, Jing-Xue Chu, Yun-Shan Wang   +4 more
doaj   +1 more source

A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy—Adolescent Skills Training To Group Counseling In Schools [PDF]

, 2016
Given the rise in depression disorders in adolescence, it is important to develop and study depression prevention programs for this age group. The current study examined the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a ...
Benas, J. S., Gallop, R., Gillham, Jane, Mufson, L., Schueler, C. M., Young, J. F.   +5 more
core   +1 more source

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes [PDF]

, 2017
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).
A Ablasser, A Dempsey, AM Herzner, B Zhong, CD Conrady, CK Holm, D Cuchet-Lourenço, D Gao, DL Burdette, EE Gray, FO Nestle, G Yi, GC Carter, GL Smith, H Ishikawa, H Ishikawa, H Konno, J Rehwinkel, J Zhang, K Hansen, K Mukai, KA Horan, KL Jønsson, KM Storek, KMJ Sparrer, L Li, L Strähle, L Sun, L Unterholzner, L Unterholzner, L Zhang, M Kalamvoki, MH Orzalli, MH Orzalli, MR Jakobsen, MR Thompson, N Dobbs, Q Wang, RD Everett, S Chiliveru, S Liu, T Jin, T Li, T Saitoh, T Tsuchida, V Hornung, X Cai, X Zhang, X-D Li, Y Okabe, Y Wang, Z Li, Z Zhang   +52 more
core   +5 more sources

CGAS: comparative genomic analysis server [PDF]

Bioinformatics, 2009
Abstract Summary: Comparative approach is one of the most essential methods for extracting functional and evolutionary information from genomic sequences. So far, a number of sequence comparison tools have been developed, and most are either for on-site use, requiring program installation but providing a wide variety of analyses, or for ...
Itoh, Masumi, Watanabe, Hidemi
openaire   +2 more sources