Results 51 to 60 of about 31,976 (243)
Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]
, 2017 The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J. +3 more
core +1 more source
Advances in Marine Sciences, 2017 环鸟苷酸-腺苷酸合成酶(cyclic GMP-AMP synthase, cGAS)是一种核酸转移酶，在哺乳动物中具有DNA 感受器的功能，能识别胞质DNA并产生cGAMP (cyclic GMP-AMP)，激活干扰素刺激蛋白(stimulator of interferon genes, STING)，调控下游的I型干扰素(interferon, IFN)和其他细胞因子的分泌，启动机体的免疫反应。cGAS不仅能够抗病毒，也能抵抗细菌的感染。结构上，cGAS由氨基端的DNA结合位点，中间的催化结构域以及羧基端保守的Mab-21 (male abnormal 21)结构域组成，属于MAB21家族蛋白。进化分析发现，脊椎动物的cGAS来源于祖先Mab-21结构域 ...
openaire +2 more sources
Advanced Sensor Research, EarlyView.Fast response, zero‐power, text or image sensors utilizing light transmission or reflection, and no unfavorable color change judgments, are fabricated using printed nematic liquid crystals patterned on reactive alignment layers, permit ppt‐ to ppb‐level sensitivity, and were field‐tested with active firefighters.
Ryan A. Williams +9 more
wiley +1 more source
Type I interferons in tuberculosis: Foe and occasionally friend [PDF]
, 2018 Tuberculosis remains one of the leading causes of mortality worldwide, and, despite its clinical significance, there are still significant gaps in our understanding of pathogenic and protective mechanisms triggered by Mycobacterium tuberculosis infection.
Mayer-Barber, K +3 more
core +1 more source
AAVR Expression is Essential for AAV Vector Transduction in Sensory Hair Cells
Advanced Science, EarlyView.Decreased sensitivity to AAV vector transduction in the outer hair cells (OHCs) of adult mice is primarily attributed to reduction of AAVR (Kiaa0319l; Au040320). Knockout of AAVR reduces AAV vector transduction efficiency in both inner hair cells (IHCs) and OHCs in neonatal mice.
Fan Wu +8 more
wiley +1 more source
Advanced Science, EarlyView.ACLY is vital for early embryo development. IGF‐1 activates AKT to phosphorylate ACLY, driving its nuclear localization and recruitment of HATs (P300/HAT1), boosting acetyl‐CoA production and histone acetylation for transcriptional activation. Conversely, ACLY deficiency (via knockdown, knockout, or AKT inhibition) reduces nuclear acetyl‐CoA, disrupts ...
Yerong Ma +18 more
wiley +1 more source
Prevailing dust-transport directions on comet 67P/Churyumov-Gerasimenko
, 2015 Dust transport and deposition behind larger boulders on the comet 67P/Churyumov-Gerasimenko (67P/C-G) have been observed by the Rosetta mission. We present a mechanism for dust transport vectors based on a homogenous surface activity model incorporating ...
Kramer, Tobias, Noack, Matthias
core +1 more source
Fault Tolerant Scalable Support for Network Portability and Traffic Engineering [PDF]
, 2007 The P-SHIM6 architecture provides ISP independence to IPv6 sites without compromising scalability. This architecture is based on a middle-box, the P-SHIM6, which manages the SHIM6 protocol exchange on behalf of the nodes of a site, which are configured ...
Azcorra, Arturo +2 more
core +3 more sources
SnapShot: CGAS-STING Signaling
Cell, 2018 CGAS responds to cytosolic DNA by initiating a STING-dependent response that ultimately engages innate immune effectors to ensure the preservation of organismal homeostasis.
Sandra Demaria +3 more
openaire +2 more sources
Advanced Science, EarlyView.This study explores the use of ultrasound contrast agents loaded with Stimulator of Interferon Genes (STING) agonists as an approach to activate the body's immune system against cancer. Termed Microbubble‐assisted UltraSound‐guided Immunotherapy of Cancer (MUSIC), this strategy effectively inhibits tumor growth and improves survival in mouse models of ...
Sina Khorsandi +12 more
wiley +1 more source