Results 51 to 60 of about 41,079 (213)

Cell-free protein synthesis with technical additives – expanding the parameter space of in vitro gene expression

Beilstein Journal of Organic Chemistry
Biocatalysis has established itself as a successful tool in organic synthesis. A particularly fast technique for screening enzymes is the in vitro expression or cell-free protein synthesis (CFPS).
Tabea Bartsch, Stephan Lütz, Katrin Rosenthal   +2 more
doaj   +1 more source

CGAS: comparative genomic analysis server [PDF]

Bioinformatics, 2009
Abstract Summary: Comparative approach is one of the most essential methods for extracting functional and evolutionary information from genomic sequences. So far, a number of sequence comparison tools have been developed, and most are either for on-site use, requiring program installation but providing a wide variety of analyses, or for ...
Itoh, Masumi, Watanabe, Hidemi
openaire   +2 more sources

A Randomized Depression Prevention Trial Comparing Interpersonal Psychotherapy—Adolescent Skills Training To Group Counseling In Schools [PDF]

, 2016
Given the rise in depression disorders in adolescence, it is important to develop and study depression prevention programs for this age group. The current study examined the efficacy of Interpersonal Psychotherapy-Adolescent Skills Training (IPT-AST), a ...
Benas, J. S., Gallop, R., Gillham, Jane, Mufson, L., Schueler, C. M., Young, J. F.   +5 more
core   +1 more source

Two-phase distribution in the vertical flow line of a domestic wet central heating system [PDF]

, 2013
The theoretical and experimental aspects of bubble distribution in bubbly two-phase flow are reviewed in the context of the micro bubbles present in a domestic gas fired wet central heating system.
Fsadni, A.M., Ge, Y.T.
core   +4 more sources

Epigallocatechin-3-Gallate Protects H2O2-Induced Nucleus Pulposus Cell Apoptosis and Inflammation by Inhibiting cGAS/Sting/NLRP3 Activation

Drug Design, Development and Therapy, 2020
Yixing Tian, Zhaohua Bao, Yiming Ji, Xin Mei, Huilin Yang Department of Orthopedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, People’s Republic of ChinaCorrespondence: Huilin Yang Email suzhouspine@163 ...
Tian Y, Bao Z, Ji Y, Mei X, Yang H
doaj  

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Mediators of Inflammation, 2015
Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation.
Yan Wang, Guo-Hua Su, Fang Zhang, Jing-Xue Chu, Yun-Shan Wang   +4 more
doaj   +1 more source

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes [PDF]

, 2017
Many human cells can sense the presence of exogenous DNA during infection though the cytosolic DNA receptor cyclic GMP-AMP synthase (cGAS), which produces the second messenger cyclic GMP-AMP (cGAMP).
A Ablasser, A Dempsey, AM Herzner, B Zhong, CD Conrady, CK Holm, D Cuchet-Lourenço, D Gao, DL Burdette, EE Gray, FO Nestle, G Yi, GC Carter, GL Smith, H Ishikawa, H Ishikawa, H Konno, J Rehwinkel, J Zhang, K Hansen, K Mukai, KA Horan, KL Jønsson, KM Storek, KMJ Sparrer, L Li, L Strähle, L Sun, L Unterholzner, L Unterholzner, L Zhang, M Kalamvoki, MH Orzalli, MH Orzalli, MR Jakobsen, MR Thompson, N Dobbs, Q Wang, RD Everett, S Chiliveru, S Liu, T Jin, T Li, T Saitoh, T Tsuchida, V Hornung, X Cai, X Zhang, X-D Li, Y Okabe, Y Wang, Z Li, Z Zhang   +52 more
core   +5 more sources

An API for IPv6 Multihoming based on HBA and CGA [PDF]

, 2005
EUNICE 2005. IFIP International Workshop on Networked Applications, Colmenarejo, Madrid/Spain, 6–8 July, 2005. (Proceedings of the 11th Open European Summer School EUNICE 2005: Networked Applications)This paper proposes an API for Multihoming in IPv6 ...
Bagnulo Braun, Marcelo Gabriel, García Martínez, Alberto, Martinez Yelmo, Isaias   +2 more
core   +2 more sources

Inhibition of cGAS Reduces Brain Injury and Facilitates Neurological Recovery via the STING-Mediated Signaling Pathway After Germinal Matrix Hemorrhage in Neonatal Mice

Journal of Integrative Neuroscience
Background: Germinal matrix hemorrhage (GMH) is a common complication of premature infants with lifelong neurological consequences. Inflammation-mediated blood-brain barrier (BBB) disruption has been implicated as a main mechanism of ...
Yiheng Wang, Xuhui Yin, Xiaoli Zhang, Xixiao Zhu, Yiting Luo, Bing-Qiao Zhao   +5 more
doaj   +1 more source

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

eLife, 2019
cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated.
Hannah E Volkman, Stephanie Cambier, Elizabeth E Gray, Daniel B Stetson   +3 more
doaj   +1 more source