Results 61 to 70 of about 41,079 (213)

A Multiphase Model for the Intracluster Medium [PDF]

, 1999
Constraints on the clustered mass density \Omega_m of the universe derived from the mean intracluster gas fraction of X-ray clusters may be biased by a single-phase assumption for the thermodynamic structure of the intracluster medium (ICM). We propose a
A. E. Evrard, Birkinshaw M., Cavaliere A., Cen R., Cole S., D. Nagai, David L. P., Eke V. R., Fabian A. C., Frenk C. S., Gunn K. F., Hamuy M., Inagaki Y., Irwin J. A., Irwin J. A., Jones M., M. E. Sulkanen, Mohr J. J., Navarro J. F., Neumann D. M., Nulsen P. E. J., Peres C. B., Raymond J. C., Riess A. G., Thomas P., Thomas P. A., White D. A., White S. D. M., Zaroubi S.   +28 more
core   +3 more sources

Melatonin alleviates neuroinflammation in ischemic stroke by regulating cyclic GMP-AMP synthase– mediated microglial pyroptosis signaling

Neural Regeneration Research
Inflammation plays a key role in driving the secondary brain injury that follows ischemic stroke. Melatonin is an endogenous neuroendocrine hormone that regulates mitochondrial homeostasis.
Qian Li, Lin Feng, Yu Tian, Erliang Guo, Yiran Li, Jingyan Niu, Haodong Pan, Chun Dang, Yaoheng Lu, Lihua Wang   +9 more
doaj   +1 more source

Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? [PDF]

, 2014
The effect of roasting of coffee beans and the extraction of ground coffee with different volumes of hot pressurised water on the caffeine and the total caffeoylquinic acids (CQAs) content of the resultant beverages was investigated.
Alan Crozier, Concepción Cid, Daniele Del Rio, Iziar A. Ludwig, Luca Calani, Michael E. J. Lean, Pedro Mena   +6 more
core   +1 more source

ZYG11B potentiates the antiviral innate immune response by enhancing cGAS-DNA binding and condensation

Cell Reports, 2023
Summary: As a key dsDNA recognition receptor, cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) plays a vital role in innate immune responses. Activated cGAS, by sensing DNA, catalyzes the synthesis of the secondary messenger cyclic GMP-AMP (cGAMP)
Jie Zhang, Er-Chi Zhou, Yan He, Ze-Lin Chai, Ben-Zhe Ji, Yi Tu, Han-Ling Wang, Wen-Qiang Wu, Yong Liu, Xing-Hua Zhang, Yu Liu   +10 more
doaj   +1 more source

Using stepped-care approaches within internet-based interventions for youth anxiety: Three case studies. [PDF]

, 2019
Background There are a lack of clear guidelines for the dissemination of Internet-based cognitive behaviour therapy (ICBT) for childhood and adolescent anxiety in routine care.
Baldwin, Sarah, Donovan, Caroline L., Ford, Martelle, March, Sonja, Spence, Susan H.   +4 more
core   +2 more sources

The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response

JCI Insight, 2023
Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SRC is
William Dunker, Shivam A. Zaver, Jose Mario Bello Pineda, Cameron J. Howard, Robert K. Bradley, Joshua J. Woodward   +5 more
doaj   +1 more source

The multiple faces of cGAS-STING in antitumor immunity: prospects and challenges

Medical Review
As a key sensor of double-stranded DNA (dsDNA), cyclic GMP-AMP synthase (cGAS) detects cytosolic dsDNA and initiates the synthesis of 2′3′ cyclic GMP-AMP (cGAMP) that activates the stimulator of interferon genes (STING).
Zhou Zheqi, Huang Sanling, Fan Fangying, Xu Yan, Moore Casey, Li Sirui, Han Chuanhui   +6 more
doaj   +1 more source

Role and Mechanism of cGAS-STING Pathway in Cardiovascular System

Reviews in Cardiovascular Medicine
The cyclic guanosine monophosphate-adenosine monophosphate (GMP-AMP) synthase (cGAS)-stimulator of interferon genes (STING) pathway is a part of the innate immune system that plays a role in the cardiovascular system.
Xianqiang Yu, Silin Pan
doaj   +1 more source

Airway epithelial cGAS inhibits LPS-induced acute lung injury through CREB signaling

Cell Death and Disease, 2023
Increased levels of cytosolic DNA in lung tissues play an important role in acute lung injury. However, the detailed mechanisms involved remain elusive.
Zhangchu Jin, Zhehua Shao, Shiyi Yang, Anyi Guo, Yinling Han, Yinfang Wu, Yun Zhao, Yanping Wu, Jiaxin Shen, Min Zhang, Xueqin Zhan, Wenqi Diao, Songmin Ying, Chao Zhang, Wen Li, Huahao Shen, Zhihua Chen, Fugui Yan   +17 more
doaj   +1 more source

An API for IPv6 Multihoming [PDF]

, 2006
IFIP International Workshop on Networked Applications, Colmenarejo, Madrid/Spain, 6?8 July, 2005This paper proposes an API for Multihoming in IPv6. This API is based on the Hash Based Addresses and Cryptographically Generated Addresses approaches, which ...
Bagnulo Braun, Marcelo Gabriel, García Martínez, Alberto, Martinez Yelmo, Isaias   +2 more
core   +2 more sources