Results 61 to 70 of about 43,268 (339)

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Cyclic GMP-AMP Synthase Is Required for Cell Proliferation and Inflammatory Responses in Rheumatoid Arthritis Synoviocytes

Mediators of Inflammation, 2015
Rheumatoid arthritis (RA) is characterized by inflammatory cell infiltration, fibroblast-like synoviocytes (FLS) invasive proliferation, and joint destruction. Cyclic GMP-AMP synthase (cGAS) is a cytosolic DNA sensor that induces immune activation.
Yan Wang, Guo-Hua Su, Fang Zhang, Jing-Xue Chu, Yun-Shan Wang   +4 more
doaj   +1 more source

The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Nature
Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7.
P. Xu, Ying Liu, Chong Liu, Baptiste Guey, Lingyun Li, Pauline Mélénec, Jonathan Ricci, A. Ablasser   +7 more
semanticscholar   +1 more source

Role of the cGAS–STING pathway in systemic and organ-specific diseases

Nature Reviews Nephrology, 2022
Cells are equipped with numerous sensors that recognize nucleic acids, which probably evolved for defence against viruses. Once triggered, these sensors stimulate the production of type I interferons and other cytokines that activate immune cells and ...
Sladjana Skopelja-Gardner, J. An, K. Elkon   +2 more
semanticscholar   +1 more source

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Proximity labeling reveals OTUD3 as a DNA-binding deubiquitinase of cGAS

Cell Reports, 2023
Summary: Cyclic GMP-AMP synthase (cGAS), as the major DNA sensor, initiates DNA-stimulated innate immune responses and is essential for a healthy immune system.
Heng Lyu, Le Sun, Zhenyu Guan, Jinxin Li, Changsong Yin, Yaoyang Zhang, Hong Jiang   +6 more
doaj  

Tight nuclear tethering of cGAS is essential for preventing autoreactivity

eLife, 2019
cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated.
Hannah E Volkman, Stephanie Cambier, Elizabeth E Gray, Daniel B Stetson   +3 more
doaj   +1 more source

A protein-based cGAS-STING nanoagonist enhances T cell-mediated anti-tumor immune responses

Nature Communications, 2022
cGAS-STING pathway is a key DNA-sensing machinery and emerges as a promising target to overcome the immunoresistance of solid tumors. Here we describe a bovine serum albumin (BSA)/ferritin-based nanoagonist incorporating manganese (II) ions and β ...
Xuan Wang, Yingqi Liu, Chencheng Xue, Yan Hu, Yuanyuan Zhao, K. Cai, Menghuan Li, Zhong Luo   +7 more
semanticscholar   +1 more source

cGAS Dimerization Entangles DNA Recognition [PDF]

Immunity, 2013
Detection of foreign DNA in the cell cytosol triggers potent antiviral responses. In this issue of Immunity, Li et al. (2013) provide new structural and biochemical data indicating that a cytosolic DNA sensor, cyclic GMP-AMP synthase (cGAS), is activated by DNA-induced dimerization.
Philip J. Kranzusch, Russell E. Vance
openaire   +3 more sources

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source