Results 61 to 70 of about 45,269 (354)
Advanced Functional Materials, EarlyView.We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj +21 more
wiley +1 more source
The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response
JCI Insight, 2023 Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SRC is
William Dunker +5 more
doaj +1 more source
Variations in caffeine and chlorogenic acid contents of coffees: what are we drinking? [PDF]
, 2014 The effect of roasting of coffee beans and the extraction of ground coffee with different volumes of hot pressurised water on the caffeine and the total caffeoylquinic acids (CQAs) content of the resultant beverages was investigated.
Alan Crozier +6 more
core +1 more source
Advanced Functional Materials, EarlyView.A bimetallic Mn–Ca nanoreactor (MCC) is developed as a non‐nucleotide STING nanoagonist for cancer metalloimmunotherapy. MCC induces Ca2+ overload and hydroxyl radical generation, resulting in mitochondrial damage and mtDNA release. The released mtDNA cooperates with Mn2+ to robustly activate cGAS–STING signaling.
Xin Wang Mo +7 more
wiley +1 more source
Tight nuclear tethering of cGAS is essential for preventing autoreactivity
eLife, 2019 cGAS is an intracellular innate immune sensor that detects double-stranded DNA. The presence of billions of base pairs of genomic DNA in all nucleated cells raises the question of how cGAS is not constitutively activated.
Hannah E Volkman +3 more
doaj +1 more source
Topoisomerase II inhibitors induce DNA damage-dependent interferon responses circumventing Ebola virus immune evasion [PDF]
, 2017 Ebola virus (EBOV) protein VP35 inhibits production of interferon alpha/beta (IFN) by blocking RIG-I-like receptor signaling pathways, thereby promoting virus replication and pathogenesis.
Adolfo García-Sastre +13 more
core +3 more sources
Advanced Functional Materials, EarlyView.The cGAS‐STING pathway boosts HCC antitumor immunity but lacks specific activation. Nanoplatform ZMRPF induces HCC ferroptosis via lipid ROS, releasing mtDNA. It synergizes with ZMRPF‐released Mn2⁺ to activate cGAS‐STING, amplifies antigen‐presenting cell activity, reverses HCC immunosuppression, and enables robust systemic antitumor immunity ...
Yuchen Zhang +13 more
wiley +1 more source
Two-phase distribution in the vertical flow line of a domestic wet central heating system [PDF]
, 2013 The theoretical and experimental aspects of bubble distribution in bubbly two-phase flow are reviewed in the context of the micro bubbles present in a domestic gas fired wet central heating system.
Fsadni, A.M., Ge, Y.T.
core +4 more sources
Cell Reports, 2023 Summary: As a key dsDNA recognition receptor, cyclic guanosine monophosphate (GMP)-AMP synthase (cGAS) plays a vital role in innate immune responses. Activated cGAS, by sensing DNA, catalyzes the synthesis of the secondary messenger cyclic GMP-AMP (cGAMP)
Jie Zhang +10 more
doaj +1 more source
An API for IPv6 Multihoming based on HBA and CGA [PDF]
, 2005 EUNICE 2005. IFIP International Workshop on Networked Applications, Colmenarejo, Madrid/Spain, 6–8 July, 2005. (Proceedings of the 11th Open European Summer School EUNICE 2005: Networked Applications)This paper proposes an API for Multihoming in IPv6 ...
Bagnulo Braun, Marcelo Gabriel +2 more
core +2 more sources