The Role of cGMP-Dependent Protein Kinase in Controlling Cardiomyocyte cGMP [PDF]
Circulation Research, 2010 See related article, pages 1232–1240 The role of cGMP as a second messenger in physiological and pathophysiological processes is widely appreciated.1,–,3 The successes of drugs that target the cGMP-signaling pathway (nitrovasodilators and PDE5 inhibitors [sildenafil, tadalafil, vardenafil]) have inspired interest in other cardiovascular benefits that ...
Sharron H. Francis
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A new plant guanosine cyclase ZjGC found from jujube regulates growth and development via endogenous hormones [PDF]
Frontiers in Plant ScienceCyclic guanosine monophosphate (cGMP) is an important second messenger involved in many physiological processes. Guanylate cyclase (GC), the key synthetase of cGMP, has been identified in many microorganisms and mammals, but very few in plants for their ...
Xin Zhao +8 more
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Antinociceptive and anti-inflammatory effect of a standardized fraction of Oenothera rosea L'Hér. ex Aiton and its possible mechanism of action in mice [PDF]
Avicenna Journal of Phytomedicine, 2022 Objective: This study was conducted to investigate the antinociceptive and anti-inflammatory effect of ethyl acetate fraction of Oenothera rosea (EAOr) and the mechanism involved, in mice.Materials and Methods: The antinociceptive activity was tested ...
Rodrigo Vargas-Ruiz +6 more
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C-type natriuretic peptide mitigates apoptosis in ovarian granulosa cells through the cGMP pathway independent of PKG signaling. [PDF]
J Ovarian ResWei Y +6 more
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Potential and limitations of PKA/ PKG inhibitors for platelet studies
Platelets, 2022 Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova +3 more
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Cells, 2022 The therapeutic benefit of stimulating the cGMP pathway as a form of treatment to combat heart failure, as well as other fibrotic pathologies, has become well established.
Maria Faleeva +11 more
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Efficacy of a novel water soluble curcumin derivative versus Tadalafile in mediating erectile function [PDF]
Journal of Bioscience and Applied Research, 2015 The present study was conducted to assess the efficacy of a novel curcumin derivative (NCD) versus Tadalafile in erectile signaling. The study was conducted on 15 control male rats and 75 diabetic male rats divided into the following groups:, diabetic ...
SA.M. Zaahkouk +4 more
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Biology Open, 2020 Cystic fibrosis (CF) is a genetic disease characterized by progressive lung and chronic digestive manifestations. We have shown that therapeutic doses of vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor, corrects CF Transmembrane conductance ...
Barbara Dhooghe +7 more
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Targeting the nitric oxide/cGMP signaling pathway to treat chronic pain
Neural Regeneration Research, 2023 Nitric oxide (NO)/cyclic guanosine 3′,5′-monophosphate (cGMP) signaling has been shown to act as a mediator involved in pain transmission and processing. In this review, we summarize and discuss the mechanisms of the NO/cGMP signaling pathway involved in
Dan-Yang Li +8 more
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cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action [PDF]
Pharmacological Reviews, 2010 To date, studies suggest that biological signaling by nitric oxide (NO) is primarily mediated by cGMP, which is synthesized by NO-activated guanylyl cyclases and broken down by cyclic nucleotide phosphodiesterases (PDEs). Effects of cGMP occur through three main groups of cellular targets: cGMP-dependent protein kinases (PKGs), cGMP-gated cation ...
Sharron H, Francis +3 more
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