Results 1 to 10 of about 148,798 (282)

A shear-dependent NO-cGMP-cGKI cascade in platelets acts as an auto-regulatory brake of thrombosis

Nature Communications, 2018
Nitric oxide (NO) inhibits thrombosis in part by stimulating cyclic guanosine monophosphate (cGMP) production and cGMP-dependent protein kinase I (cGKI) activity in platelets. Here, Wen et al.
Lai Wen, Susanne Feil, Markus Wolters, Martin Thunemann, Frank Regler, Kjestine Schmidt, Andreas Friebe, Marcus Olbrich, Harald Langer, Meinrad Gawaz, Cor de Wit, Robert Feil   +11 more
doaj   +2 more sources

Spectrofluorimetric determination of cyclic guanosine monophosphate in human nasal secretions: evaluating levels in healthy individuals and patients with olfactory dysfunction [PDF]

BMC Chemistry
Cyclic guanosine monophosphate (cGMP) is a second messenger involved in olfactory signal transduction. cGMP levels modulate the sensitivity of olfactory neurons and are implicated in olfactory dysfunctions.
Mohamed H. Abdelazim, Faisal Alsenani, Adnan Alharbi, Fahad H. Baali, Abdulaziz H. Baali, Maram H. Abduljabbar, Reem M. Alnemari, Majed A. Algarni   +7 more
doaj   +2 more sources

Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) patients and mouse models show learning and memory impairment associated with hippocampal dysfunction. The neuronal nitric oxide synthase/3',5'-cyclic guanosine monophosphate (nNOS/cGMP) pathway is implicated in synaptic ...
Ana Saavedra, Albert Giralt, Helena Arumí, Jordi Alberch, Esther Pérez-Navarro   +4 more
doaj   +2 more sources

The NO/cGMP pathway inhibits transient cAMP signals through the activation of PDE2 in striatal neurons

Frontiers in Cellular Neuroscience, 2013
The NO-cGMP signaling plays an important role in the regulation of striatal function although the mechanisms of action of cGMP specifically in medium spiny neurons (MSNs) remain unclear. Using genetically encoded fluorescent biosensors, including a novel
Marina ePolito, Marina ePolito, Jeffrey eKlarenbeek, Kees eJalink, Danièle eTritsch, Danièle eTritsch, Pierre eVincent, Pierre eVincent, Liliana R.V. Castro, Liliana R.V. Castro   +9 more
doaj   +2 more sources

Antinociceptive and anti-inflammatory effect of a standardized fraction of Oenothera rosea L'Hér. ex Aiton and its possible mechanism of action in mice [PDF]

Avicenna Journal of Phytomedicine, 2022
Objective: This study was conducted to investigate the antinociceptive and anti-inflammatory effect of ethyl acetate fraction of Oenothera rosea (EAOr) and the mechanism involved, in mice.Materials and Methods: The antinociceptive activity was tested ...
Rodrigo Vargas-Ruiz, Jose Eduardo Roa-Coria, Arturo Mora-Olivo, Alejandro Zamilpa, Maribel Lucila Herrera-Ruiz, Rosa Issel Acosta-Gonzalez, Rosa Mariana Montiel-Ruiz   +6 more
doaj   +1 more source

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

Cell, 2021
2′,3′-cAMP is a positional isomer of the well-established second messenger 3′,5′-cAMP, but little is known on the biology of this noncanonical cyclic nucleotide monophosphate (cNMP). Toll/interleukin-1 receptor (TIR) domains of nucleotide-binding leucine-
Dongli Yu, Wen Song, Eddie Yong Jun Tan, Li Liu, Yu Cao, J. Jirschitzka, Ertong Li, E. Logemann, Chenrui Xu, Shijia Huang, Ao Jia, Xiaoyu Chang, Zhifu Han, Bin Wu, P. Schulze-Lefert, J. Chai   +15 more
semanticscholar   +1 more source

Potential and limitations of PKA/ PKG inhibitors for platelet studies

Platelets, 2022
Cyclic nucleotides (cAMP and cGMP) and corresponding protein kinases, protein kinase A (PKA) and protein kinase G (PKG), are the main intracellular mediators of endothelium-derived platelet inhibitors. Pharmacological PKA/PKG inhibitors are often used to
Valentina Shpakova, Natalia Rukoyatkina, Ulrich Walter, Stepan Gambaryan   +3 more
doaj   +1 more source

Compartmentation of cGMP Signaling in Induced Pluripotent Stem Cell Derived Cardiomyocytes during Prolonged Culture

Cells, 2022
The therapeutic benefit of stimulating the cGMP pathway as a form of treatment to combat heart failure, as well as other fibrotic pathologies, has become well established.
Maria Faleeva, Ivan Diakonov, Prashant Srivastava, Masoud Ramuz, Gaia Calamera, Kjetil Wessel Andressen, Nadja Bork, Lorenza Tsansizi, Marie-Victoire Cosson, Andreia Sofia Bernardo, Viacheslav Nikolaev, Julia Gorelik   +11 more
doaj   +1 more source

Vardenafil increases intracellular accumulation of the most prevalent mutant cystic fibrosis transmembrane conductance regulator (CTFR) in human bronchial epithelial cells

Biology Open, 2020
Cystic fibrosis (CF) is a genetic disease characterized by progressive lung and chronic digestive manifestations. We have shown that therapeutic doses of vardenafil, a phosphodiesterase type 5 (PDE5) inhibitor, corrects CF Transmembrane conductance ...
Barbara Dhooghe, Caroline Bouzin, Angélique Mottais, Emmanuel Hermans, Martial Delion, Nadtha Panin, Sabrina Noel, Teresinha Leal   +7 more
doaj   +1 more source

cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Most studies of the regulation of proteolysis by the ubiquitin proteasome system have focused on the control of ubiquitination. However, it is now clear that the activity of the 26S proteasome and rates of protein degradation in cells are ...
Jordan J. S. VerPlank, Sylwia D. Tyrkalska, Angeleen Fleming, D. Rubinsztein, A. Goldberg   +4 more
semanticscholar   +1 more source