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Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase
Cellular Signalling, 2002The structure of cyclic GMP (cGMP)-binding (cGB), cGMP specific phosphodiesterase (PDE5) comprises several domains. We have used RT-PCR methods to clone the noncatalytic cGB domains of PDE5 from human colon cancer cell RNA and constructed glutathione-S-transferase (GST) fusion proteins to express and study the domains.
Li, Liu +4 more
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Allosteric Activation of cGMP-Specific, cGMP-Binding Phosphodiesterase (PDE5) by cGMP
Biochemistry, 2002The effects of cGMP binding on the catalytic activity of cGMP-specific, cGMP-binding phosphodiesterase (PDE5) are unclear because cGMP interacts with both allosteric and catalytic sites specifically. We studied the effects of cGMP on the hydrolysis of a fluorescent substrate analogue, 2'-O-anthraniloyl cGMP, by PDE5 partially purified from rat ...
Daisuke, Okada, Shigeki, Asakawa
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A primer for measuring cGMP signaling and cGMP-mediated vascular relaxation
Nitric Oxide, 2021Soluble guanylyl cyclase (sGC, also called GC1) is the main receptor for nitric oxide (NO) that catalyzes the production of the second messenger molecule, 3'5' cyclic guanosine monophosphate (cGMP) leading to vasorelaxation, and inhibition of leukocyte recruitment and platelet aggregation.
Adam C. Straub, Annie Beuve
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cGMP Signaling through cAMP- and cGMP-Dependent Protein Kinases
1995Publisher Summary The signaling pathways by which nitric oxide (NO) affects cell function, are by no means limited to the stimulation of guanylate cyclase. Concentrations of NO that activate guanylate cyclase may also have other effects on cells.
T M, Lincoln +4 more
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Progesterone substitutes: cGMP mediation
Neuroscience & Biobehavioral Reviews, 1986Over the past 20 years many investigators have shown that one can facilitate sexual receptivity in estrogen-primed rats either by giving progesterone or a drug which stimulates or inhibits a neurotransmitter system. Drugs which have been reported to substitute for progesterone include cholinergic agonists, serotonergic agonists and antagonists ...
R E, Whalen, A H, Lauber
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Insights into cGMP signalling derived from cGMP kinase knockout mice
Frontiers in Bioscience, 2005cGMP signalling plays an important physiological role in diverse organs including the vasculature, the GI-tract and the nervous system. Furthermore, cGMP-elevating substances such as glyceryl trinitrate are important drugs used in cardiovascular diseases.
Jens, Schlossmann +2 more
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