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cGMP and cell processing

Cytotherapy, 1999
Over the past 20 years cell processing has changed. What an under statement! The types of cells processed, the complexity of the procedures, the addition of gene therapy and ex vivo cell expansion protocols together challenge the laboratory scientist.
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cGMP production in bacteria

Molecular and Cellular Biochemistry, 2009
Production of cGMP in bacteria has been studied since the early 1970s. From the beginning on it proved to be a challenging topic. In Escherichia coli the cGMP levels were two orders of magnitude lower than the corresponding cAMP levels. Furthermore, no specific cGMP receptor protein was identified in the bacterium and a physiological role of cGMP in ...
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NO-cGMP-System

2018
NO wird in Endothelzellen synthetisiert und aktiviert in glatten Muskelzellen die sGC, die den second messenger cGMP produziert. Die wichtigste Funktion von cGMP ist die Relaxation glatter Muskelzellen. cGMP wird uber die PDE5 abgebaut. Der NO-Donator GTN aktiviert die sGC und relaxiert Muskelzellen.
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cGMP and cGMP-Dependent Protein Kinase in Platelets and Blood Cells

2009
Platelets are specialized adhesive cells that play a key role in normal and pathological hemostasis through their ability to rapidly adhere to subendothelial matrix proteins (platelet adhesion) and to other activated platelets (platelet aggregation). NO plays a crucial role in preventing platelet adhesion and aggregation.
Ulrich, Walter, Stepan, Gambaryan
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cGMP signal termination

Biochemical Society Transactions, 1996
N J, Pyne, V, Arshavsky, A, Lochhead
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Can’t Ignore cGMPs

2004
Chemistry, Manufacturing and Controls (CMC) is the body of information that includes the manufacturing, testing, and release of product. Good manufacturing practices are the actual requirements that need to be followed to ensure that the product meets its intended characteristics.
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CGMP

2011
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