Results 31 to 40 of about 55,160 (145)

Sildenafil Potentiates a cGMP-Dependent Pathway to Promote Melanoma Growth

Cell Reports, 2016
Sildenafil, an inhibitor of the cGMP-degrading phosphodiesterase 5 that is used to treat erectile dysfunction, has been linked to an increased risk of melanoma. Here, we have examined the potential connection between cGMP-dependent signaling cascades and
Sandeep Dhayade, Susanne Kaesler, Tobias Sinnberg, Hyazinth Dobrowinski, Stefanie Peters, Ulrike Naumann, He Liu, Robert E. Hunger, Martin Thunemann, Tilo Biedermann, Birgit Schittek, Hans-Uwe Simon, Susanne Feil, Robert Feil   +13 more
doaj   +1 more source

Cyclic GMP and PKG Signaling in Heart Failure

Frontiers in Pharmacology, 2022
Cyclic guanosine monophosphate (cGMP), produced by guanylate cyclase (GC), activates protein kinase G (PKG) and regulates cardiac remodeling. cGMP/PKG signal is activated by two intrinsic pathways: nitric oxide (NO)-soluble GC and natriuretic peptide (NP)
Genri Numata, Genri Numata, Eiki Takimoto, Eiki Takimoto   +3 more
doaj   +1 more source

Ultrasound‐Responsive Dual‐Prodrug Nanoassembly for “Fenestrae‐Restoration Strategy” in Liver Fibrosis Therapy

Advanced Materials, EarlyView.
ABSTRACT Liver fibrosis is a serious yet reversible intermediate stage in the progression of liver disease, which can ultimately advance to cirrhosis and hepatocellular carcinoma. Targeted and selective inhibition of activated hepatic stellate cells (aHSCs) has emerged as a promising therapeutic strategy for the treatment of liver fibrosis.
Shutong Liu, Mengyao Zhang, Zitong Qiu, Xinyi Liu, Yunsheng Dou, Sona Krizkova, Zheyi Li, Zbynek Heger, Nan Li   +8 more
wiley   +1 more source

Intracellular cGMP increase is not involved in thyroid cancer cell death

PLoS ONE, 2023
Introduction Type 5 phosphodiesterase (PDE5) inhibitors (PDE5i) lead to intracellular cyclic-guanosine monophosphate (cGMP) increase and are used for clinical treatment of erectile dysfunction.
Sara D’ Alessandro, Elia Paradiso, Clara Lazzaretti, Samantha Sperduti, Carmela Perri, Francesco Antoniani, Sara Righi, Manuela Simoni, Giulia Brigante, Livio Casarini   +9 more
doaj   +2 more sources

Hyperammonemia impairs long-term potentiation in hippocampus by altering the modulation of cGMP-degrading phosphodiesterase by protein kinase G

Neurobiology of Disease, 2004
Hyperammonemia impairs long-term potentiation (LTP) in hippocampus, by an unknown mechanism. LTP in hippocampal slices requires activation of the soluble guanylate cyclase (sGC)-protein kinase G (PKG)-cGMP-degrading phosphodiesterase pathway.
Pilar Monfort, Marı́a-Dolores Muñoz, Vicente Felipo   +2 more
doaj   +1 more source

Increased bioavailability of cyclic guanylate monophosphate prevents retinal ganglion cell degeneration

Neurobiology of Disease, 2019
The nitric oxide – guanylyl cyclase-1 – cyclic guanylate monophosphate (NO-GC-1–cGMP) pathway has emerged as a potential pathogenic mechanism for glaucoma, a common intraocular pressure (IOP)-related optic neuropathy characterized by the degeneration of ...
Lauren K. Wareham, Ana C. Dordea, Grigorij Schleifer, Vincent Yao, Annabelle Batten, Fei Fei, Joseph Mertz, Meredith Gregory-Ksander, Louis R. Pasquale, Emmanuel S. Buys, Rebecca M. Sappington   +10 more
doaj   +1 more source

Rise of cGMP by partial phosphodiesterase-3A degradation enhances cardioprotection during hypoxia

Redox Biology, 2021
3′,5′-cyclic guanosine monophosphate (cGMP) is a druggable second messenger regulating cell growth and survival in a plethora of cells and disease states, many of which are associated with hypoxia. For example, in myocardial infarction and heart failure (
Nadja I. Bork, Anna Kuret, Melanie Cruz Santos, Cristina E. Molina, Beate Reiter, Hermann Reichenspurner, Andreas Friebe, Boris V. Skryabin, Timofey S. Rozhdestvensky, Michaela Kuhn, Robert Lukowski, Viacheslav O. Nikolaev   +11 more
doaj   +1 more source

cGMP Signaling and Vascular Smooth Muscle Cell Plasticity

Journal of Cardiovascular Development and Disease, 2018
Cyclic GMP regulates multiple cell types and functions of the cardiovascular system. This review summarizes the effects of cGMP on the growth and survival of vascular smooth muscle cells (VSMCs), which display remarkable phenotypic plasticity during the ...
Moritz Lehners, Hyazinth Dobrowinski, Susanne Feil, Robert Feil   +3 more
doaj   +1 more source

Association of elevated cyclic GMP levels with hemodynamic changes in HFrEF patients treated with sacubitril/valsartan and vericiguat: a pilot study

International Journal of Cardiology: Heart & Vasculature
Background: Patients with heart failure (HF) often present with a relative deficiency of cyclic guanosine monophosphate (cGMP) despite elevated B-type natriuretic peptide (BNP) levels.
Takumi Inoue, Hiroyuki Takahama, Hideaki Suzuki, Marina Arai, Nobuhiro Kikuchi, Taijyu Satoh, Nobuhiro Yaoita, Saori Yamamoto, Kotaro Nochioka, Makoto Nakano, Shunsuke Tatebe, Jun Takahashi, Naoto Minamino, Satoshi Yasuda   +13 more
doaj   +1 more source

Activation of HIV-1 expression and replication by cGMP dependent protein kinase type 1-β (PKG1β)

Retrovirology, 2007
The effect of cGMP (cyclic GMP) dependent protein kinase 1-β (PKG1-β) and cGMP analogues on transcriptional activity and replication of human immunodeficiency virus type 1 (HIV-1) was investigated.
Jeang Kuan-Teh, Yedavalli Venkat RK, Lee Jia   +2 more
doaj   +1 more source