Results 41 to 50 of about 55,160 (145)

Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension.

PLoS ONE, 2013
NO/cGMP signaling plays an important role in vascular relaxation and regulation of blood pressure. The key enzyme in the cascade, the NO-stimulated cGMP-forming guanylyl cyclase exists in two enzymatically indistinguishable isoforms (NO-GC1, NO-GC2) with
Johannes Stegbauer, Sebastian Friedrich, Sebastian A Potthoff, Kathrin Broekmans, Miriam M Cortese-Krott, Ivo Quack, Lars Christian Rump, Doris Koesling, Evanthia Mergia   +8 more
doaj   +1 more source

Nitrated Nucleotides: New Players in Signaling Pathways of Reactive Nitrogen and Oxygen Species in Plants

Frontiers in Plant Science, 2020
Nitration of diverse biomolecules, including proteins, lipids and nucleic acid, by reactive nitrogen species represents one of the key mechanisms mediating nitric oxide (NO) biological activity across all types of organisms.
Marek Petřivalský, Lenka Luhová
doaj   +1 more source

Interconvertible cGMP-free and cGMP-bound forms of cGMP-dependent protein kinase in mammalian tissues.

Journal of Biological Chemistry, 1987
Several vascular and nonvascular mammalian tissue extracts exhibited variable amounts of two peaks (peaks I and II) of cGMP-dependent protein kinase by NaCl elution of DEAE columns. When [3H]cGMP was added to the extracts before chromatography, a peak of protein-bound [3H]cGMP coeluted with peak II.
L, Wolfe, S H, Francis, L R, Landiss, J D, Corbin   +3 more
openaire   +2 more sources

Real-time imaging of cGMP signaling shows pronounced differences between glomerular endothelial cells and podocytes

Scientific Reports
Recent clinical trials of drugs enhancing cyclic guanosine monophosphate (cGMP) signaling for cardiovascular diseases have renewed interest in cGMP biology within the kidney.
Nelli Rutkowski, Frederik Görlitz, Eva Wiesner, Julia Binz-Lotter, Susanne Feil, Robert Feil, Thomas Benzing, Matthias J. Hackl   +7 more
doaj   +1 more source

A new plant guanosine cyclase ZjGC found from jujube regulates growth and development via endogenous hormones

Frontiers in Plant Science
Cyclic guanosine monophosphate (cGMP) is an important second messenger involved in many physiological processes. Guanylate cyclase (GC), the key synthetase of cGMP, has been identified in many microorganisms and mammals, but very few in plants for their ...
Xin Zhao, Haonan Cao, Yao Liu, Junyan Mai, Fangyuan Yang, Zhiguo Liu, Zhiguo Liu, Mengjun Liu, Mengjun Liu   +8 more
doaj   +1 more source

Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide

Frontiers in Neuroscience, 2019
PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms, Frank S. Menniti, Christopher J. Schmidt   +2 more
doaj   +1 more source

Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease. [PDF]

PLoS ONE, 2013
Huntington's disease (HD) patients and mouse models show learning and memory impairment associated with hippocampal dysfunction. The neuronal nitric oxide synthase/3',5'-cyclic guanosine monophosphate (nNOS/cGMP) pathway is implicated in synaptic ...
Ana Saavedra, Albert Giralt, Helena Arumí, Jordi Alberch, Esther Pérez-Navarro   +4 more
doaj   +1 more source

Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain

Frontiers in Molecular Neuroscience, 2014
Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation and release of cyclic guanosine-3’,5’-monophosphate (
Gerhard eHannig, Boris eTchernychev, Caroline B Kurtz, Alexander P Bryant, Mark G Currie, Inmaculada eSilos-Santiago   +5 more
doaj   +1 more source

Effects of casein glycomacropeptide supplementation on growth performance, intestinal morphology, intestinal barrier permeability and inflammatory responses in Escherichia coli K88 challenged piglets

Animal Nutrition, 2015
Casein glycomacropeptide (CGMP) is a bioactive peptide derived from milk with multiple functions. This study was aimed at evaluating the effects of CGMP as a potential feed additive on growth performance, intestinal morphology, intestinal barrier ...
Yili Rong, Zeqing Lu, Haiwen Zhang, Lin Zhang, Deguang Song, Yizhen Wang   +5 more
doaj   +1 more source

Spectrofluorimetric determination of cyclic guanosine monophosphate in human nasal secretions: evaluating levels in healthy individuals and patients with olfactory dysfunction

BMC Chemistry
Cyclic guanosine monophosphate (cGMP) is a second messenger involved in olfactory signal transduction. cGMP levels modulate the sensitivity of olfactory neurons and are implicated in olfactory dysfunctions.
Mohamed H. Abdelazim, Faisal Alsenani, Adnan Alharbi, Fahad H. Baali, Abdulaziz H. Baali, Maram H. Abduljabbar, Reem M. Alnemari, Majed A. Algarni   +7 more
doaj   +1 more source