Results 51 to 60 of about 62,675 (241)
Phosphodiesterase 5 attenuates the vasodilatory response in renovascular hypertension.
PLoS ONE, 2013 NO/cGMP signaling plays an important role in vascular relaxation and regulation of blood pressure. The key enzyme in the cascade, the NO-stimulated cGMP-forming guanylyl cyclase exists in two enzymatically indistinguishable isoforms (NO-GC1, NO-GC2) with
Johannes Stegbauer +8 more
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Frontiers in Plant Science, 2020 Nitration of diverse biomolecules, including proteins, lipids and nucleic acid, by reactive nitrogen species represents one of the key mechanisms mediating nitric oxide (NO) biological activity across all types of organisms.
Marek Petřivalský, Lenka Luhová
doaj +1 more source
Journal of Biological Chemistry, 1987 Several vascular and nonvascular mammalian tissue extracts exhibited variable amounts of two peaks (peaks I and II) of cGMP-dependent protein kinase by NaCl elution of DEAE columns. When [3H]cGMP was added to the extracts before chromatography, a peak of protein-bound [3H]cGMP coeluted with peak II.
L, Wolfe +3 more
openaire +2 more sources
Biotechnology and Applied Biochemistry, EarlyView.ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin +8 more
wiley +1 more source
Biotechnology and Bioengineering, EarlyView.ABSTRACT The competition in the biopharmaceutical market is increasing due to the market entry of biosimilars and rising costs in research and development of new drugs. Hence, continuous manufacturing gained significant attention due to its potential in reducing production cycle times and costs, as well as the possibility of real‐time release testing ...
Mariana Carvalho +4 more
wiley +1 more source
Phosphodiesterase 9A in Brain Regulates cGMP Signaling Independent of Nitric-Oxide
Frontiers in Neuroscience, 2019 PDE9A is a cGMP-specific phosphodiesterase expressed in neurons throughout the brain that has attracted attention as a therapeutic target to treat cognitive disorders.
John F. Harms +2 more
doaj +1 more source
BMEMat, EarlyView.A series of in vitro experiments, numerical simulations and in vivo experiments were conducted to jointly evaluate the effects of different thicknesses of bioabsorbable polymer vascular stents on their radial capacity, hemodynamics and in vivo outcomes.
Chong Chen +9 more
wiley +1 more source
A Natural Resource‐Based View of Circular Economy Practices in the Pharmaceutical Industry
Business Strategy and the Environment, EarlyView.ABSTRACT Pharmaceutical industry is facing escalating environmental sustainability issues including gaseous emissions, waste generation, and excessive consumption of energy and non‐renewable materials. Nevertheless, the adoption of sustainable business models such as the circular economy (CE) is still in its infancy in this sector due to complex ...
Amna Farrukh, Muhammad Sohaib Sajjad
wiley +1 more source
Guanylate cyclase-C/cGMP: an emerging pathway in the regulation of visceral pain
Frontiers in Molecular Neuroscience, 2014 Activation of guanylate cyclase-C (GC-C) expressed predominantly on intestinal epithelial cells by guanylin, uroguanylin or the closely related GC-C agonist peptide, linaclotide, stimulates generation and release of cyclic guanosine-3’,5’-monophosphate (
Gerhard eHannig +5 more
doaj +1 more source
Regulation of hippocampal cGMP levels as a candidate to treat cognitive deficits in Huntington's disease. [PDF]
PLoS ONE, 2013 Huntington's disease (HD) patients and mouse models show learning and memory impairment associated with hippocampal dysfunction. The neuronal nitric oxide synthase/3',5'-cyclic guanosine monophosphate (nNOS/cGMP) pathway is implicated in synaptic ...
Ana Saavedra +4 more
doaj +1 more source