Results 51 to 60 of about 55,160 (145)
A cyclic GMP signalling module that regulates gliding motility in a malaria parasite.
PLoS Pathogens, 2009 The ookinete is a motile stage in the malaria life cycle which forms in the mosquito blood meal from the zygote. Ookinetes use an acto-myosin motor to glide towards and penetrate the midgut wall to establish infection in the vector.
Robert W Moon +8 more
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Orphanet Journal of Rare Diseases, 2019 In phenylketonuria, casein glycomacropeptide (CGMP) requires modification with the addition of some essential and semi essential amino acids to ensure suitability as a protein substitute.
A. Daly +9 more
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Pharmacological manipulation of cGMP and NO/cGMP in CNS drug discovery
Nitric Oxide, 2019 The development of small molecule modulators of NO/cGMP signaling for use in the CNS has lagged far behind the use of such clinical agents in the periphery, despite the central role played by NO/cGMP in learning and memory, and the substantial evidence that this signaling pathway is perturbed in neurodegenerative disorders, including Alzheimer's ...
Michael A. Hollas +4 more
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The Role of cGMP-Dependent Protein Kinase in Controlling Cardiomyocyte cGMP [PDF]
Circulation Research, 2010 See related article, pages 1232–1240 The role of cGMP as a second messenger in physiological and pathophysiological processes is widely appreciated.1,–,3 The successes of drugs that target the cGMP-signaling pathway (nitrovasodilators and PDE5 inhibitors [sildenafil, tadalafil, vardenafil]) have inspired interest in other cardiovascular benefits that ...
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Research progress of phosphodiesterase 5 in heart failure [PDF]
Jichu yixue yu linchuangPhosphodiesterase 5 (PDE5), a cyclic guanosine monophosphate (cGMP)-specific hydrolase, is targets cGMP produced by soluble guanosine cyclase (sGC) that is activated by nitric oxide (NO). It catalyzes the hydrolysis of the phosphodiester bond in cGMP and
YANG Yang, ZHANG Yarong, YANG Hongqin, WANG Jing, ZHAO Hongmei
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SponGee: A Genetic Tool for Subcellular and Cell-Specific cGMP Manipulation
Cell Reports, 2019 Summary: cGMP is critical to a variety of cellular processes, but the available tools to interfere with endogenous cGMP lack cellular and subcellular specificity. We introduce SponGee, a genetically encoded chelator of this cyclic nucleotide that enables
Oriol Ros +12 more
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Frontiers in Molecular NeuroscienceA major intracellular messenger implicated in synaptic plasticity and cognitive functions both in health and disease is cyclic GMP (cGMP). Utilizing a photoactivatable guanylyl cyclase (BlgC) actuator to increase cGMP in dentate granule neurons of the ...
Jelena Borovac +16 more
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Controlling Myocyte cGMP [PDF]
Circulation Research, 2009 See related article, pages 956–964 CGMP is a central intracellular second-messenger regulating numerous cellular functions. In the cardiac myocyte, cGMP mediates effects of nitric oxide and atrial natriuretic peptide, whereas its counterpart, cAMP, mediates catecholamine signaling.
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CNP-induced cGMP signaling reduces growth cone stiffness and Ca2+ levels in embryonic DRG neurons
Frontiers in Molecular NeuroscienceA cyclic guanosine monophosphate (cGMP) signaling pathway composed of the extracellular ligand C-type natriuretic peptide (CNP), the transmembrane natriuretic peptide receptor 2 (Npr2), and the cGMP-dependent protein kinase I (cGKI) regulates axon ...
Aylin Balmes +10 more
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Molecular patterns of the NO-sGC-cGMP pathway in progressive and regressive liver fibrosis models
Scientific ReportsThe nitric oxide (NO)—soluble guanylate cyclase (sGC)—cyclic guanosine-monophosphate (cGMP) pathway is impaired in liver fibrosis. We investigated expression patterns of NO-sGC-cGMP components via RT-qPCR in various rat models of liver fibrosis and ...
Thomas Sorz-Nechay +17 more
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