Results 41 to 50 of about 43,468 (306)

Intranasal calcitonin gene-related peptide administration impairs fear memory retention in mice through the PKD/p-HDAC5/Npas4 pathway

Scientific Reports, 2022
The calcitonin gene-related peptide (CGRP) suppresses fear memory retention in mice. Although intracerebroventricular administration of CGRP alters the fear memory processes, making it a promising therapeutic strategy for post-traumatic stress disorder ...
Narumi Hashikawa-Hobara, Yoshikazu Yoneyama, Kyoushiro Fujiwara, Naoya Hashikawa   +3 more
doaj   +1 more source

Structure and dynamics of the CGRP receptor in apo and peptide-bound forms

Science, 2021
Dynamic activation of a GPCR G protein–coupled receptors (GPCRs) coordinate a complex information flow between the outside and inside of a cell. An increasing number of GPCR structures provide insight into function.
T. Josephs, M. Belousoff, Yi-Lynn Liang, S. Piper, Jianjun Cao, Daniel J. Garama, K. Leach, K. Gregory, A. Christopoulos, D. Hay, R. Danev, D. Wootten, P. Sexton   +12 more
semanticscholar   +1 more source

Dietary capsaicin normalizes CGRP peptidergic DRG neurons in experimental diabetic peripheral neuropathy

Scientific Reports, 2021
Diabetic sensory neuropathy leads to impairment of peripheral sensory nerves and downregulation of calcitonin gene-related peptide (CGRP) in a functionally specific subset of peripheral sensory neurons mediating pain. Whether CGRP plays a neuroprotective
Xiao-Yi Zhang, Zheng Guo, Tu-Ping Li, Tao Sun   +3 more
doaj   +1 more source

Six-month therapy of CGRP monoclonal antibodies in real-world clinical practice: an interim analysis of efficacy and safety data

Медицинский совет, 2022
Introduction. Migraine is one of the most common disabling neurological disorders. Recently developed monoclonal antibodies to calcitonin gene-related peptide (CGRP) or its receptor are the first targeted medication for preventive therapy of both ...
N. V. Vashchenko, A. M. Uzhakhov, M. V. Bogorodskaya, D. Z. Korobkova, Ju. E. Azimova, K. V. Skorobogatykh   +5 more
doaj   +1 more source

Role of calcitonin gene-related peptide in bone repair after cyclic fatigue loading. [PDF]

PLoS ONE, 2011
Calcitonin gene related peptide (CGRP) is a neuropeptide that is abundant in the sensory neurons which innervate bone. The effects of CGRP on isolated bone cells have been widely studied, and CGRP is currently considered to be an osteoanabolic peptide ...
Susannah J Sample, Zhengling Hao, Aliya P Wilson, Peter Muir   +3 more
doaj   +1 more source

CGRP and the Trigeminal System in Migraine

Headache, 2019
The goal of this narrative review is to provide an overview of migraine pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) within the context of the trigeminovascular system.
S. Iyengar, Kirk W. Johnson, M. Ossipov, S. Aurora   +3 more
semanticscholar   +1 more source

Chronic Migraine: Diagnosis, Characteristics, Lifestyle Modification, Trigger Reduction and Treatment

Journal of Pharmacy and Bioallied Sciences
The most prevalent brain condition that impairs function is migraine. A chronic migraine is a very incapacitating disorder that is defined by having a migraine that lasts for at least 10 days every month.
Roshan Kumar Jha, Ranjit Ambad, Dhruba Hari Chandi, Obaid Noman   +3 more
doaj   +1 more source

The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats

Drug Delivery, 2021
The calcitonin gene-related peptide (CGRP) has been demonstrated relating to vascular and inflammatory regulations not only the nerve systems. As the anti-inflammation factor and the most potent vasodilator, the CGRP holds therapeutic potentials for the ...
Fang Wang, Yu Deng, Jieting Wang, Luying Yu, Fadian Ding, Wei Lian, Qicai Liu, Xinhua Lin   +7 more
doaj   +1 more source

CGRP sensory neurons promote tissue healing via neutrophils and macrophages

Nature
The immune system has a critical role in orchestrating tissue healing. As a result, regenerative strategies that control immune components have proved effective1,2. This is particularly relevant when immune dysregulation that results from conditions such
Yen-Zhen Lu, Bhavana Nayer, Shailendra Kumar Singh, Yasmin K Alshoubaki, Elle Yuan, Anthony J Park, Kenta Maruyama, Shizuo Akira, Mikaël M. Martino   +8 more
semanticscholar   +1 more source

CGRP receptor antagonists for migraine. Are they also AMY1 receptor antagonists?

British Journal of Pharmacology, 2021
The development of several drugs that target the calcitonin gene‐related peptide (CGRP) system has been a major breakthrough in the pharmacological management of migraine.
Michael L. Garelja, C. Walker, D. Hay
semanticscholar   +1 more source