Results 81 to 90 of about 43,468 (306)
Scientific Reports, 2021 This study aimed to explore the effect of calcitonin gene-related peptide (CGRP) on bladder smooth muscle cells (BSMCs) under high glucose (HG) treatment in vitro. BSMCs from Sprague–Dawley rat bladders were cultured and passaged in vitro.
Jun Xue +6 more
doaj +1 more source
CGRP Receptor Antagonism and Migraine [PDF]
Neurotherapeutics, 2010 Calcitonin gene-related peptide (CGRP) is expressed throughout the central and peripheral nervous systems, consistent with control of vasodilatation, nociception, motor function, secretion, and olfaction. alphaCGRP is prominently localized in primary spinal afferent C and ADelta fibers of sensory ganglia, and betaCGRP is the main isoform in the enteric
Lars, Edvinsson, Tony W, Ho
openaire +2 more sources
Ibrain, EarlyView.Chemotherapy‐induced peripheral neuropathy (CIPN) remains a major clinical challenge, with central sensitization considered an important pathological mechanism in its occurrence and persistence. This review focuses on spinal astrocytes and microglia, systematically summarizing the pathological mechanisms of spinal glial cells involved in CIPN caused by
Long Gu, Song Cao, Yonghuai Feng
wiley +1 more source
Therapeutics and Clinical Risk Management, 2023 Claudia Altamura,1,2 Nicoletta Brunelli,1,2 Marilena Marcosano,1,2 Alessandro Alesina,1,2 Luisa Fofi,1,2 Fabrizio Vernieri1,2 1Fondazione Policlinico Universitario Campus Bio-Medico, Roma, 00128, Italy; 2Unit of Headache and Neurosonology, Department of ...
Altamura C +5 more
doaj
CGRP outflow into jugular blood and cerebrospinal fluid and permeance for CGRP of rat dura mater
The Journal of Headache and Pain, 2021 Background Calcitonin gene-related peptide (CGRP) is released from activated meningeal afferent fibres in the cranial dura mater, which likely accompanies severe headache attacks.
Miriam Risch +3 more
doaj +1 more source
Anterior Nasal Nerves: A Cadaveric Anatomic and Immunohistochemical Analysis
The Laryngoscope, EarlyView.Anterior nasal nerves (ANNs) were identified in all cadavers, with more supplying the anterolateral nasal wall (ALNW) than the anterior portion of the inferior turbinate (IT), between the pyriform aperture (PA) and middle turbinate (MT). Both sensory and autonomic nerve markers were also identified in the ANNs.
John R. Craig +6 more
wiley +1 more source
Antagonism of CGRP Signaling by Rimegepant at Two Receptors
Frontiers in Pharmacology, 2020 The “gepants” are a class of calcitonin gene-related peptide (CGRP) receptor antagonist molecules that have been developed for the prevention and treatment of migraine.
Kylie S. Pan +3 more
semanticscholar +1 more source
The Laryngoscope, EarlyView.This prospective pilot study aims to compare nasal mucosal sensitivity to air‐jet stimuli between ENS patients and patients who underwent septoplasty/turbinate reduction (septo‐turb) surgery, but without ENS symptoms. The ENS group had a significantly higher (less sensitive) threshold than the septo‐turb group for the septum opposing the center of the ...
Kanghyun Kim +8 more
wiley +1 more source
Calcitonin Gene-Related Peptide (CGRP) and Cluster Headache
Brain Science, 2020 Cluster headache (CH) is a severe primary headache with a prevalence of 1/1000 individuals, and a predominance in men. Calcitonin gene-related peptide (CGRP) is a potent vasodilator, originating in trigeminal neurons and has a central role in CH ...
Andrea Carmine Belin +2 more
semanticscholar +1 more source
Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy, EarlyView.ABSTRACT The treatment of migraine is hampered by inter‐individual variability, leading to an inefficient “trial and error” approach. Artificial intelligence (AI) and machine learning (ML) offer a path towards precision medicine by predicting therapeutic outcomes.
Martina Giacon, Salvatore Terrazzino
wiley +1 more source