25-Hydroxycholesterol Inhibition of Lassa Virus Infection through Aberrant GP1 Glycosylation
mBio, 2016 Lassa virus (LASV) infection is a major public health concern due to high fatality rates and limited effective treatment. The interferon-stimulated gene cholesterol 25-hydroxylase (CH25H) encodes an enzyme that catalyzes the production of 25 ...
Punya Shrivastava-Ranjan +6 more
doaj +1 more source
25-Hydroxycholesterol exacerbates vascular leak during acute lung injury
JCI Insight, 2023 Cholesterol-25-hydroxylase (CH25H), the biosynthetic enzyme for 25-hydroxycholesterol (25HC), is most highly expressed in the lung, but its role in lung biology is poorly defined.
Jennifer H. Madenspacher +14 more
doaj +1 more source
Cholesterolomics: An update [PDF]
, 2017 Cholesterolomics can be regarded as the identification and quantification of cholesterol, its precursors post squalene, and metabolites of cholesterol and of its precursors, in a biological sample.
Alvelius +86 more
core +1 more source
The stability of mRNA influences the temporal order of the induction of genes encoding inflammatory molecules [PDF]
, 2009 The inflammatory response plays out over time in a reproducible and organized way after an initiating stimulus. Here we show that genes activated in cultured mouse fibroblasts in response to the cytokine tumor necrosis factor could be categorized into ...
Baltimore, David, Hao, Shengli
core +2 more sources
Eimeria bovis infection modulates endothelial host cell cholesterol metabolism for successful replication [PDF]
, 2015 During first merogony Eimeria bovis forms large macromeronts in endothelial host cells containing >120 000 merozoites I. During multiplication, large amounts of cholesterol are indispensable for the enormous offspring membrane production.
Gimpl, Gerald +6 more
core +2 more sources
Research progress on the mechanism of cholesterol-25-hydroxylase in intestinal immunity
Frontiers in Immunology, 2023 Inflammatory bowel disease (IBD), a general term encompassing Crohn’s disease (CD) and ulcerative colitis (UC), and other conditions, is a chronic and relapsing autoimmune disease that can occur in any part of the digestive tract.
Guoqiang Zhong +4 more
doaj +1 more source
Disruption of cholesterol homeostasis triggers periodontal inflammation and alveolar bone loss
Experimental and Molecular Medicine, 2023 Oral diseases exhibit a significant association with metabolic syndrome, including dyslipidemia. However, direct evidence supporting this relationship is lacking, and the involvement of cholesterol metabolism in the pathogenesis of periodontitis (PD) has
Thanh-Tam Tran +10 more
doaj +1 more source
Identifying Reliable Diagnostic/Predictive Biomarkers for Rheumatoid Arthritis [PDF]
, 2018 Introduction and objective: Elevated C-reactive protein is usually a good indicator of rheumatoid arthritis (RA); however, there are limitations that compromise its specificity and therefore there is an urgent need to identify more reliable diagnostic ...
Darekar, Ashish +4 more
core +1 more source
Cell Reports, 2022 Summary: Influx of eosinophils into the lungs is typically associated with type II responses during allergy and fungal and parasitic infections. However, we previously reported that eosinophils accumulate in lung lesions during type I inflammatory ...
Andrea C. Bohrer +29 more
doaj +1 more source
Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes [PDF]
, 2016 Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA.
Anastasina, Maria +15 more
core +3 more sources