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Formas clínicas y diagnóstico de la enfermedad de Chagas e inmunosupresores

Revista Argentina de Reumatología, 2019
La enfermedad de Chagas constituye una infección severa de alta prevalencia en Argentina y otros países latinoamericanos. La administración de drogas reumáticas inmunosupresoras en estos pacientes, muchas veces es necesaria, pero no se conoce aún la ...
Darío Scublinsky, M. V. Pinoni, F. Ibelli, A. Valledor, E.R. Soriano   +4 more
doaj   +3 more sources

In vitro and in vivo studies of the trypanocidal properties of WRR-483 against Trypanosoma cruzi. [PDF]

, 2010
BackgroundCruzain, the major cysteine protease of Trypanosoma cruzi, is an essential enzyme for the parasite life cycle and has been validated as a viable target to treat Chagas' disease.
Brinen, Linda S, Chen, Yen Ting, Doyle, Patricia S, Hansell, Elizabeth, Kerr, Iain D, McKerrow, James H, Roush, William R   +6 more
core   +48 more sources

Chagas disease. [PDF]

CMAJ
Chagas disease persists as a global public health problem due to the high morbidity and mortality burden. Despite the possibility of a cure and advances in transmission control, epidemiological transformations, such as urbanisation and globalisation, and the emerging importance of oral and vertical transmission mean that Chagas disease should be ...
Billick MJ, Silverberg SL.
europepmc   +4 more sources

The Learning Curve for Peroral Endoscopic Myotomy in Latin America: A Slide to the Right? [PDF]

Clinical Endoscopy, 2021
Background/Aims Peroral endoscopic myotomy (POEM) has been increasingly used for achalasia in Latin America, where Chagas disease is prevalent, and this makes POEM more challenging.
Michel Kahaleh, Amy Tyberg, Supriya Suresh, Arnon Lambroza, Fernando Rodriguez Casas, Mario Rey, Jose Nieto, Guadalupe Ma Martínez, Felipe Zamarripa, Vitor Arantes, Maria G Porfilio, Monica Gaidhane, Pietro Familiari, Juan Carlos Carames, Romulo Vargas-Rubio, Raul Canadas, Albis Hani, Guillermo Munoz, Bismarck Castillo, Eduardo T Moura, Farias F Galileu, Hannah P Lukashok, Carlos Robles-Medranda, Eduardo G de Moura   +23 more
doaj   +1 more source

Seroprevalencia de la enfermedad de Chagas (Trypanosoma cruzi) en la población escolar e incidencia parasitaria de Triatoma dimidiata en la parroquia Juan Gómez Rendón, Provincia del Guayas, Ecuador

Revista Científica de Ciencias Naturales y Ambientales, 2021
Se realizaron encuestas serológicas y entomológicas para determinar la prevalencia de la enfermedad de Chagas, la presencia del vector y el índice tripano triatomino, en la población escolar de la parroquia Juan Gómez Rendón, en la provincia del Guayas,
Verónica Calderón, Jaime Buestán
doaj   +1 more source

In Silico Antiprotozoal Evaluation of 1,4-Naphthoquinone Derivatives against Chagas and Leishmaniasis Diseases Using QSAR, Molecular Docking, and ADME Approaches

Pharmaceuticals, 2022
Chagas and leishmaniasis are two neglected diseases considered as public health problems worldwide, for which there is no effective, low-cost, and low-toxicity treatment for the host.
Lina S. Prieto Cárdenas, Karen A. Arias Soler, Diana L. Nossa González, Wilson E. Rozo Núñez, Agobardo Cárdenas-Chaparro, Pablo R. Duchowicz, Jovanny A. Gómez Castaño   +6 more
doaj   +1 more source

Epidemiologia de Triatominos en la Provincia de Río Negro

Ciencia Veterinaria, 2021
Chagas es una enfermedad endemoepidémica de transmisión vec-torial en la Provincia de Rio Negro causada por Trypanosoma cruzi, transmitido por insectos vectores denominados triatominos (vinchu-cas).
Crowley P, Labanchi JL, Dade M, Daniele M, Calabro A, Grizmado C, Ochoa A, Hernandez P, Arezo M, Larrieu E   +9 more
doaj   +1 more source

Chagas Disease [PDF]

Pediatrics In Review, 2016
Approximately 8 million people worldwide are infected by the protozoan parasite Trypanosoma cruzi, the causative agent of Chagas disease. After a latent period that can last years or decades, 10% to 30% of infected people develop serious complications, such as cardiomyopathy or gastrointestinal dysfunction.
Tustin, Aaron W., Bowman, Natalie M.
openaire   +2 more sources

One-Pot Multicomponent Synthesis of Methoxybenzo[h]quinoline-3-carbonitrile Derivatives; Anti-Chagas, X-ray, and In Silico ADME/Tox Profiling Studies

Molecules, 2021
Several methoxybenzo[h]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioning approach to developing compounds with anti-prostate cancer and anti-Chagas disease properties.
Hegira Ramírez, Katiuska Charris, Esteban Fernandez-Moreira, Benjamín Nogueda-Torres, Mario V. Capparelli, Jorge Ángel, Jaime Charris   +6 more
doaj   +1 more source

Mitochondrial DNA Haplogroups and Variants Predispose to Chagas Disease Cardiomyopathy

Hearts, 2023
Cardiomyopathies are major causes of heart failure. Chagas disease (CD) is caused by the parasite Trypanosoma cruzi, and it is endemic in Central and South America.
Frédéric Gallardo, Pauline Brochet, David Goudenège, João Paulo Silva Nunes, Pauline Andrieux, Barbara Maria Ianni, Amanda Farage Frade, Charles Mady, Ronaldo Honorato Barros Santos, Andreia Kuramoto, Samuel Steffen, Antonio Noedir Stolf, Pablo Pomerantzeff, Alfredo Inacio Fiorelli, Edimar Alcides Bocchi, Cristina Wide Pissetti, Bruno Saba, Fabrício C. Dias, Marcelo Ferraz Sampaio, Fabio Antônio Gaiotto, José Antonio Marin-Neto, Abílio Fragata, Ricardo Costa Fernandes Zaniratto, Sergio Siqueira, Giselle De Lima Peixoto, Fernando Bacal, Paula Buck, Rafael Ribeiro Almeida, Hui Tzu Lin-Wang, André Schmidt, Mario Hiroyuki Hirata, Eduardo Antonio Donadi, Alexandre Costa Pereira, Virmondes Rodrigues Junior, Martino Martinelli, Michel Naslavsky, Jorge Kalil, Vincent Procaccio, Edecio Cunha-Neto, Christophe Chevillard   +39 more
doaj   +1 more source