Electrocardiographic Abnormalities and Treatment with Benznidazole among Children with Chronic Infection by Trypanosoma cruzi: A Retrospective Cohort Study [PDF]
, 2016 Background: Chronic infection by Trypanosoma cruzi could cause heart conduction disturbances. We sought to analyze electrocardiographic abnormalities among children with chronic T. cruzi infection with and without trypanocidal treatment with benznidazole.
Colantonio, Lisandro Damián +3 more
core +40 more sources
Circulating microRNAs as biomarkers of Chagas cardiomyopathy [PDF]
Frontiers in Cardiovascular Medicine, 2023 BackgroundChagas cardiomyopathy (CHCM) is the most important clinical manifestation of Chagas disease. The analysis of cardiac miRNAs may contribute to predicting the progression to CHCM in Chagas indeterminate phase and/or to the differential diagnosis ...
Laura Antonietti +13 more
doaj +2 more sources
Chronic Chagas cardiomyopathy: a review of the main pathogenic mechanisms and the efficacy of aetiological treatment following the BENznidazole Evaluation for Interrupting Trypanosomiasis (BENEFIT) trial [PDF]
Memorias do Instituto Oswaldo Cruz, 2017 Chagas cardiomyopathy is the most frequent and most severe manifestation of chronic Chagas disease, and is one of the leading causes of morbidity and death in Latin America.
Anis Rassi Jr +2 more
doaj +2 more sources
Deficient regulatory T cell activity and low frequency of IL-17-producing T cells correlate with the extent of cardiomyopathy in human Chagas' disease. [PDF]
PLoS Neglected Tropical Diseases, 2012 BACKGROUND: Myocardium damage during Chagas' disease results from the immunological imbalance between pro- and production of anti-inflammatory cytokines and has been explained based on the Th1-Th2 dichotomy and regulatory T cell activity.
Paulo Marcos Matta Guedes +11 more
doaj +3 more sources
Omega-3 supplementation on inflammatory markers in patients with chronic Chagas cardiomyopathy: a randomized clinical study [PDF]
Nutrition Journal, 2017 Background Several studies have been focusing on the effect of omega-3 polyunsaturated fatty acids on modulation of inflammatory markers in several cardiopathies.
Paula Simplício da Silva +10 more
doaj +2 more sources
Antigen-Based Nano-Immunotherapy Controls Parasite Persistence, Inflammatory and Oxidative Stress, and Cardiac Fibrosis, the Hallmarks of Chronic Chagas Cardiomyopathy, in A Mouse Model of Trypanosoma cruzi Infection [PDF]
Vaccines, 2020 Chagas cardiomyopathy is caused by Trypanosoma cruzi (Tc). We identified two candidate antigens (TcG2 and TcG4) that elicit antibodies and T cell responses in naturally infected diverse hosts.
Nandadeva Lokugamage +4 more
doaj +2 more sources
Heart transplantation for Chagas cardiomyopathy
Revista Portuguesa de Cardiologia, 2017 Chagas disease is an endemic disease in Latin America that is increasingly found in non-endemic areas all over the world due to the flow of migrants from Central and South America.
Ana Rita Ramalho +4 more
doaj +2 more sources
Inspiratory Muscle Strength in Chagas Cardiomyopathy: A Systematic Scoping Review. [PDF]
Rev Soc Bras Med Trop, 2023 Mazzoli-Rocha F +9 more
europepmc +3 more sources
Echocardiographic predictors of mortality in heart failure from Chagas cardiomyopathy: Refining risk stratification with speckle-tracking echocardiography [PDF]
American Heart Journal PlusBackground: Chagas cardiomyopathy is a major cause of mortality in endemic regions, predicted primarily by left ventricular (LV) systolic function. Speckle-tracking echocardiography (STE)–derived strain is a sensitive tool for assessing ventricular ...
Marcelo Alves Maia +10 more
doaj +2 more sources
Case report: diagnosis of chronic Chagas cardiomyopathy using a multimodality imaging approach. [PDF]
Eur Heart J Case Rep, 2023 Li SX, Soles EO, Sharma PS, Rao AK.
europepmc +3 more sources