Canine Trypanosoma cruzi infection in the Bolivian Chaco [PDF]
, 2018 A cross-sectional study on Trypanosoma cruzi was carried out in 2013 to evaluate the role of dogs as possible source of infection for humans in two rural communities of the highly endemic Bolivian Chaco (Bartolo, Chuquisaca Department, n = 57 dogs; and ...
Bartoloni, Alessandro +9 more
core +2 more sources
Anti-Trypanosoma cruzi action of a new benzofuran derivative based on amiodarone structure [PDF]
, 2018 Chagas disease is a neglected tropical affection caused by the protozoan parasite Trypanosoma cruzi. There is no current effective treatment since the only two available drugs have a limited efficacy and produce side effects.
Benaim, Gustavo +4 more
core +1 more source
Chronic Trypanosoma cruzi infection potentiates adipose tissue macrophage polarization toward an anti-inflammatory M2 phenotype and contributes to diabetes progression in a diet-induced obesity model [PDF]
, 2016 Chronic obesity and Chagas disease (caused by the protozoan Trypanosoma cruzi) represent serious public health concerns. The interrelation between parasite infection, adipose tissue, immune system and metabolism in an obesogenic context, has not been ...
Andrada, Marta Cecilia +8 more
core +4 more sources
HIV Medicine, EarlyView.Abstract Background There are an estimated 2482 people born in Latin American countries receiving care for HIV in the United Kingdom. Although national guidance recommends screening for Trypanosoma cruzi infection (Chagas disease) in this population, there is no formal screening programme.
Natalie Elkheir +18 more
wiley +1 more source
Elevated serum levels of macrophage migration inhibitory factor and stem cell growth factor β in patients with idiopathic and systemic sclerosis associated pulmonary arterial hypertension. [PDF]
, 2015 Pulmonary arterial hypertension (PAH) can be idiopathic or secondary to autoimmune diseases, and it represents one of the most threatening complications of systemic sclerosis (SSc).
Alessandri, Cristiano +9 more
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Clinical Case Reports, Volume 14, Issue 1, January 2026.Transthoracic echocardiography demonstrating biventricular dilatation. Parasternal long‐ and short‐axis views and apical four‐ and two‐chamber views show marked left ventricular dilatation with increased end‐diastolic volume, associated with right ventricular dilatation.
Cristian Orlando Porras Bueno +3 more
wiley +1 more source
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. [PDF]
PLoS ONE, 2013 BACKGROUND:Familial aggregation of Chagas cardiac disease in T. cruzi-infected persons suggests that human genetic variation may be an important determinant of disease progression.
Xutao Deng +8 more
doaj +1 more source
Putting Infection Dynamics at the Heart of Chagas Disease. [PDF]
, 2016 In chronic Trypanosoma cruzi infections, parasite burden is controlled by effective, but nonsterilising immune responses. Infected cells are difficult to detect because they are scarce and focally distributed in multiple sites.
Kelly, John M, Lewis, Michael D
core +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 2, 29 January 2026.A. Consumption of a highsugar‐fat diet causes excess nutrients, hypertrophy and hyperplasia of adipocytes, causing obesity. Obesity leads to increased inflammatory levels in the heart, which stimulates greater activation of Metalloproteinase‐2 (MMP‐2), which has collagenolytic activity, degrading the collagen network in the heart, ultimately causing ...
Carol Cristina Vagula de Almeida de Silva +15 more
wiley +1 more source
Review of Chagas Disease and Treatment Obstacles to Eradication [PDF]
, 2019 The World Health Organization and the Center for Disease Control reports Chagas disease, or American trypanosomiasis, as a major neglected tropical disease prevalent in 21 endemic Latin American countries.
Sherman, Emily
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