Results 51 to 60 of about 12,753 (211)
Natural Products from Mexican Medicinal Plants as Promising Trypanocidal Drugs
ChemistrySelect, Volume 10, Issue 37, October 6, 2025.Chagas disease (American Trypanosomiasis) is caused by the protozoan Trypanosoma cruzi. Worldwide it is one of the seventeen neglected tropical diseases. There is a need of new drugs. This review assesses the literature (2012‐2024) of secondary metabolites isolated from Mexican plants active against this parasite.
Karla Daniela Rodríguez‐Hernández +2 more
wiley +1 more source
Revista da Sociedade Brasileira de Medicina TropicalINTRODUCTION: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades.
Katherine Yih-Jia Fu +13 more
doaj +1 more source
Arquivos Brasileiros de Cardiologia, 2014 Diagnosis, prognosis and evaluation of death risk in Chagas cardiomyopathy still constitute a challenge due to the diversity of manifestations, which determine the importance of using echocardiography, tissue Doppler and biomarkers. To evaluate, within a
Clodoval de Barros Pereira Júnior +1 more
doaj +1 more source
Serum Proteomic Signature of Human Chagasic Patients for the Identification of Novel Potential Protein Biomarkers of Disease [PDF]
, 2012 Chagas disease is initiated upon infection by Trypanosoma cruzi. Among the health consequences is a decline in heart function, and the pathophysiological mechanisms underlying this manifestation are not well understood. To explore the possible mechanisms,
Garg, Nisha Jain +5 more
core +1 more source
Treatment with a New Peroxisome Proliferator-Activated Receptor Gamma Agonist, Pyridinecarboxylic Acid Derivative, Increases Angiogenesis and Reduces Inflammatory Mediators in the Heart of Trypanosoma cruzi-Infected Mice [PDF]
, 2017 Trypanosoma cruzi infection induces an intense inflammatory response in diverse host tissues. The immune response and the microvascular abnormalities associated with infection are crucial aspects in the generation of heart damage in Chagas disease.
Carta, Davide +9 more
core +4 more sources
Exploring global and specific pathogenic mechanisms in Chronic Chagas Cardiomyopathy through multi-omics integration [PDF]
, 2023 Pauline Brochet +5 more
openalex +1 more source
Pacing and Clinical Electrophysiology, Volume 48, Issue 10, Page 1157-1166, October 2025.Distribution of distinct topographies and their relationship with NYHA classes and therapies. Each of the 111 dots represents a distinct PVC topography recorded in the 12L‐AECGs. Black dots represent PVC associated with patients classified as NYHA class I, green dots with NYHA class II, and yellow dots with NYHA class III.
Carlos Arthur Hansel Diniz da Costa +7 more
wiley +1 more source
Pathogenesis of chronic Chagas cardiomyopathy: the role of coronary microvascular derangements
Revista da Sociedade Brasileira de Medicina Tropical, 2013 There is ample experimental and clinical evidence of functional and structural microvascular abnormalities occurring in patients with Chagas cardiomyopathy, possibly due to the inflammatory process and/or autonomic disturbances caused by Trypanosoma ...
Jose Antonio Marin-Neto +2 more
doaj +1 more source
Rabbit models of heart disease. [PDF]
, 2008 Human heart disease is a major cause of death and disability. A variety of animal models of cardiac disease have been developed to better understand the etiology, cellular and molecular mechanisms of cardiac dysfunction and novel therapeutic strategies ...
Bers, Donald M, Pogwizd, Steven M
core
Emerging and under-recognized Chagas cardiomyopathy in non-endemic countries [PDF]
, 2012 Due to recent population emigration movements, an epidemic of Chagas disease is currently menacing most developed countries. The authors report the case of a 53-year-old Brazilian woman living in Europe for the last 10 years who developed heart failure ...
Cortez, J +7 more
core +1 more source