Results 61 to 70 of about 12,753 (211)

Trypanosoma Cruzi Lineages Shape Macrophage Cytokine Profiles in Single and Mixed Infections

Parasite Immunology, Volume 47, Issue 9, September 2025.
ABSTRACT Chagas disease, caused by Trypanosoma cruzi, exhibits a wide clinical spectrum, which is influenced by the parasite's extensive genetic diversity. Growing evidence indicates that human infections are often multiclonal, involving a dynamic population of parasite clones, collectively termed the “cruziome”. The immunological consequences of these
Cecília Luiza Pereira, Giovana Maria Salmazi de Carvalho, Laura Eduarda Miranda da Silva, Anna Clara Azevedo Silveira, Elida Cristina Monteiro de Oliveira, Claudio Vieira da Silva   +5 more
wiley   +1 more source

Deriving a parsimonious cardiac endpoint for use in epidemiological studies of Chagas disease: results from the Retrovirus Epidemiology Donor Study-II (REDS-II) cohort

Revista do Instituto de Medicina Tropical de São Paulo, 2021
Chagas cardiomyopathy (ChCM) is a severe consequence of Trypanosoma cruzi infection and has a range of electrocardiographic (ECG) and echocardiographic (ECHO) manifestations. There is a need for a standard and parsimonious research cardiac end point that
Lewis F. Buss, Taniela Marli Bes, Alexandre Pereira, Larissa Natany, Claudia Di Lorenzo Oliveira, Antonio Luiz P Ribeiro, Ester Cerdeira Sabino   +6 more
doaj   +1 more source

Evaluation of the metabolism of high energy phosphates in patients with Chagas' disease [PDF]

, 2010
FUNDAMENTO: Anormalidades do metabolismo miocárdico têm sido observadas em pacientes com insuficiência cardíaca de diferentes etiologias. A espectroscopia por ressonância magnética (ERM) com fósforo 31 é uma técnica não invasiva que permite a detecção de
IANNI, Bárbara Maria, KALIL-FILHO, Roberto, LEME, Ana Maria Betim Paes, MADY, Charles, PARGA, José Rodrigues, SALEMI, Vera Maria Cury, WEISS, Robert G.   +6 more
core   +1 more source

In Vitro Leishmanicidal Efficacy of Synthesized Arylidene Analogues of Glitazone

Drug Development Research, Volume 86, Issue 5, August 2025.
ABSTRACT Diabetes is a fast‐growing health issue in low‐ and middle‐income countries, with ~80% of diabetics living in the tropics and sub‐tropics. It is a deadly condition claiming the lives of millions of individuals annually, with no therapeutic treatment available to date. The management of diabetes is thus limited to symptomatic relief by glycemic
Janine Aucamp, Helena D. Janse van Rensburg, Simon S. Mnyakeni‐Moleele, Keisuke Suganuma, David D. N'Da   +4 more
wiley   +1 more source

Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.
Matheus Barbosa de Miranda, Adriene Siqueira de Melo, Mariana Silva Almeida, Silvia Martins Marinho, Wilson Oliveira Junior, Yara de Miranda Gomes   +5 more
doaj   +1 more source

Chagas disease cardiomyopathy: current concepts of an old disease Cardiomiopatia chagásica: conceitos atuais de doença antiga

Revista do Instituto de Medicina Tropical de São Paulo, 2008
Chagas disease continues to be a significant public health problem, as ca. 10 million people are still infected with T. cruzi in Latin America. Decades after primary infection, 30% of individuals can develop a form of chronic inflammatory cardiomyopathy ...
Angelina M.B. Bilate, Edecio Cunha-Neto
doaj   +1 more source

Evaluation of VDR gene polymorphisms in Trypanosoma cruzi infection and chronic Chagasic cardiomyopathy [PDF]

, 2016
Vitamin D is an important modulator of the immune response. It acts over several immune cell types where the Vitamin D receptor (VDR) is expressed.
Carmona, F.D., González, Clara Isabel, León Rodríguez, Daniel A., Martín, J.   +3 more
core   +2 more sources

Genetic Variants Affect Distinct Metabolic Pathways in Pediatric Multisystem Inflammatory Syndrome and Severe COVID‐19

Journal of Medical Virology, Volume 97, Issue 8, August 2025.
ABSTRACT The coronavirus disease 2019 (COVID‐19) pandemic has triggered a global health crisis, with over 700 million confirmed cases and at least 7 million deaths reported by early 2024. Children are less vulnerable to severe SARS‐CoV‐2 infection than adults and typically experience milder respiratory symptoms.
Alysson Henrique Urbanski, Flávia Cristina de Paula Freitas, Tiago Minuzzi Freire da Fontoura Gomes, Michelle Orane Schemberger, Bárbara Carvalho Santos dos Reis, Flavia Amêndola Anísio de Carvalho, Roberta Soares Faccion, Lucas de Almeida Machado, Deborah Antunes dos Santos, Daniela Prado Cunha, Margarida dos Santos Salú, Daniella Campelo Batalha Cox Moore, Mayra Marinho Presibella, Juliana Fontes Noguchi, Henrique Lira Borges, Lais Kimie Tomiura, Luiza Silva de Castro, Letícia Graziela Costa Santos, Esdras Matheus Gomes da Silva, Vinícius Da Silva Coutinho Parreira, Luis Gustavo Morello, Fabricio Klerynton Marchini, Maria Regina Tizzot, Mauricio Marcondes Ribas, Gilberto Pascolat, Carmen Australia Paredes Marcondes Ribas, Fábio Fernandes da Rocha Vicente, Alexandre Rossi Paschoal, Rubens Cat, Benilton de Sá Carvalho, Jaqueline Carvalho de Oliveira, Marcus F. Oliveira, Luiz Lehmann Coutinho, Acácia Maria Lourenço Francisco Nasr, Irina Nastassja Riediger, Jeanine Marie Nardin, Liya Regina Mikami, Ana Carolina Ramos Guimarães, Patricia Savio de Araujo‐Souza, Arnaldo Prata‐Barbosa, Zilton Farias Meira de Vasconcelos, Helisson Faoro, Hellen Geremias dos Santos, Fabio Passetti   +43 more
wiley   +1 more source

The burden of congenital Chagas disease and implementation of molecular diagnostic tools in Latin America [PDF]

, 2018
It is estimated that between 8000 and 15 000 Trypanosoma cruzi infected babies are born every year to infected mothers in Chagas disease endemic countries. Currently, poor access to and performance of the current diagnostic algorithm, based on microscopy
Cruz, Israel, Katz, Zachary, Ndung'u, Joseph Mathu, Picado, Albert, Redard Jacot, Maël, Schijman, Alejandro Gabriel, Sosa-Estani, Sergio Alejandro, Torrico, Faustino   +7 more
core   +1 more source

The risk of death according to left ventricular ejection fraction and right ventricular dilatation in 17 321 adults with heart failure from 40 high‐, middle‐ and low‐income countries – A Global Congestive Heart Failure (G‐CHF) study

European Journal of Heart Failure, Volume 27, Issue 7, Page 1191-1201, July 2025.
Abstract Aims The aim of this study was to describe the prognostic importance of left ventricular ejection fraction (LVEF) versus right ventricular (RV) dilatation and dysfunction in patients with heart failure (HF) from countries of different income levels. Methods and results We enrolled 17 321 participants with HF from 40 countries.
Darryl P. Leong, Philip G. Joseph, Hisham Dokainish, Stefan Störk, John V.V. McMurray, Lisa M. Mielniczuk, Sanjib Kumar Sharma, Andrés Orlandini, Kamilu M. Karaye, Antoni Bayes‐Genis, Tara McCready, Alex Grinvalds, Kumar Balasubramanian, Kelley R. Branch, Kristian Kragholm, Salim Yusuf, on behalf of the G‐CHF Investigators   +16 more
wiley   +1 more source