Results 61 to 70 of about 235,727 (237)

Emerging Trends in Left Ventricular Thrombus: A Comprehensive Review of Non-Ischemic and Ischemic Cardiopathies, Including Eosinophilic Myocarditis, Chagas Cardiomyopathy, Amyloidosis, and Innovative Anticoagulant Approaches. [PDF]

Diagnostics (Basel)
Colle B, Demeure F, Higny J, Benoit M, Henry JP, Michaux I, Robaye B, Xhaët O, Gabriel L, Guedes A, Blommaert D, Dulieu N, Berners Y, Wery F, Droogmans S, Cosyns B, Luchian ML.   +16 more
europepmc   +3 more sources

Increases in [IP3]i aggravates diastolic [Ca2+] and contractile dysfunction in Chagas' human cardiomyocytes.

PLoS Neglected Tropical Diseases, 2020
Chagas cardiomyopathy is the most severe manifestation of human Chagas disease and represents the major cause of morbidity and mortality in Latin America.
Alfredo Mijares, Raúl Espinosa, José Adams, José R Lopez   +3 more
doaj   +1 more source

Chagas disease and systemic autoimmune diseases among Bolivian patients in Switzerland

Memorias do Instituto Oswaldo Cruz, 2018
BACKGROUND Chronic cardiomyopathy occurs in 20-40% of the patients with Chagas disease. Autoimmune mechanisms may contribute to its pathogenesis. We diagnosed several cases of systemic autoimmune diseases among Bolivian migrants in Geneva with a high ...
Yves Jackson, Drenusha Vieira de Mello Pula, Axel Finckh, Carlo Chizzolini, François Chappuis   +4 more
doaj   +1 more source

Unraveling the role of miRNAs as biomarkers in Chagas cardiomyopathy: Insights into molecular pathophysiology. [PDF]

PLoS Negl Trop Dis
Ribeiro HG, Galdino OA, de Souza KSC, Rosa Neta AP, Lin-Wang HT, Cunha-Neto E, Rezende AA, Silbiger VN.   +7 more
europepmc   +3 more sources

Chagas Disease Cardiomyopathy

International Journal of Cardiovascular Sciences, 2018
Abstract Chronic Chagas disease cardiomyopathy (CCC) is a result of low-intensity, but incessant, focal fibrosing myocarditis, caused by persistent T. cruzi infection associated with inflammation, mediated by adverse immune mechanisms. About 30 percent of infected individuals have developed throughout life the chronic cardiac form of Chagas' disease ...
Simões, Marcus Vinicius, Romano, Minna Moreira Dias, Schmidt, André, Martins, Káryta Suely Macedo, Marin-Neto, José Antonio   +4 more
openaire   +3 more sources

A systematic review and meta-analysis of mortality in chronic Chagas cardiomyopathy versus other cardiomyopathies: higher risk or fiction?

Revista Española de Cardiología
INTRODUCTION AND OBJECTIVES Although multiple studies suggest that chronic Chagas cardiomyopathy (CCC) has higher mortality than other cardiomyopathies, the absence of meta-analyses supporting this perspective limits the possibility of generating robust ...
S. Gómez-Ochoa, A. Serrano-García, A. Hurtado-Ortiz, Andrea Aceros, L. Z. Rojas, Luis E Echeverría   +5 more
semanticscholar   +1 more source

Chagas cardiomyopathy and heart failure: From epidemiology to treatment.

Revista Portuguesa de Cardiologia, 2020
Chagas disease is among the neglected tropical diseases recognized by the World Health Organization that have received insufficient attention from governments and health agencies. Chagas disease is endemic in 21 Latin America regions.
É. Santos, L. Menezes Falcão
semanticscholar   +1 more source

Heart Transplantation for Chagas Cardiomyopathy [PDF]

International Journal of Cardiovascular Sciences, 2020
Abstract Heart transplantation (HT) is an established treatment for patients with advanced heart failure (HF). Chagas disease (CD), caused by the Trypanosoma cruzi (T.cruzi) is an important cause of HF in Latin America. Considering CD is a chronic infectious disease, the use of immunosuppressive therapy after HT can reactivate T.
Maria da Consolação Moreira, Fabio Morato Castilho, Renato Braulio, Guilherme Ferraz Messina de Pádua Andrade, José Renan da Cunha Melo   +4 more
openaire   +3 more sources

Inhibition of SREBP Improves Cardiac Lipidopathy, Improves Endoplasmic Reticulum Stress, and Modulates Chronic Chagas Cardiomyopathy

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2020
Background Trypanosoma cruzi is an intracellular parasite that causes debilitating chronic Chagas cardiomyopathy (CCM), for which there is no effective drug or vaccine.
J. P. Ayyappan, Kezia Lizardo, Sean Wang, E. Yurkow, J. Nagajyothi   +4 more
semanticscholar   +1 more source

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, EarlyView.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source