Results 71 to 80 of about 235,727 (237)

Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. [PDF]

PLoS ONE, 2013
BACKGROUND:Familial aggregation of Chagas cardiac disease in T. cruzi-infected persons suggests that human genetic variation may be an important determinant of disease progression.
Xutao Deng, Ester C Sabino, Edecio Cunha-Neto, Antonio L Ribeiro, Barbara Ianni, Charles Mady, Michael P Busch, Mark Seielstad, REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International   +8 more
doaj   +1 more source

TNF‐α partially modulates the endothelial dysfunction during the acute phase of Trypanosoma cruzi infection

British Journal of Pharmacology, EarlyView.
Background and Purpose Whereas the effects of Trypanosoma cruzi (T. cruzi) infection are well‐characterised in the heart, its impact on the vasculature has received little attention. In this study, we investigated the effects of acute and chronic T. cruzi infection on vascular responsiveness and the underlying mechanisms.
Thales M. H. Dourado, Wanessa M. C. Awata, Gustavo F. Pimenta, Barbara M. Marchetti, Maiara V. Providello, Sérgio De Albuquerque, Carlos R. Tirapelli   +6 more
wiley   +1 more source

Screening for Trypanosoma cruzi infection (Chagas disease) in the Latin American population living with HIV in London

HIV Medicine, EarlyView.
Abstract Background There are an estimated 2482 people born in Latin American countries receiving care for HIV in the United Kingdom. Although national guidance recommends screening for Trypanosoma cruzi infection (Chagas disease) in this population, there is no formal screening programme.
Natalie Elkheir, Shivani Singh, Birgit Barbini, Lucy Campbell, Alice Sharp, Jacqueline O'Connell, Louise Terry, Margherita Bracchi, Javier Rubio, Nicolo Girometti, Mohammed Hassan, Hannah Davies, Frank A. Post, Laura Nabarro, Debbie Nolder, Geraldine O'Hara, Julie Fox, Peter L. Chiodini, David A. J. Moore   +18 more
wiley   +1 more source

Chagas cardiomyopathy: Europe is not spared! [PDF]

European Heart Journal, 2008
Chagas’ disease was first described in 1909 by the Brazilian physician Carlos Chagas, who named the parasite Trypanosoma cruzi after his mentor, Oswaldo Cruz.1 It causes more deaths in the Americas than any other parasitic disease.1 Due to the parasite distribution throughout Central and South America, it is commonly known as the ‘American ...
Guerri Guttemberg R, Grana DR, AMBROSIO, Giuseppe, Milei J.   +3 more
openaire   +2 more sources

Paracoccidioidomycosis in Brazil: 25‐Year Nationwide Trends in Mortality, Hospitalisations and In‐Hospital Deaths of a Neglected Systemic Mycosis

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objective To analyse mortality, hospitalisations and in‐hospital mortality related to paracoccidioidomycosis (PCM) in Brazil, 2000–2024, from a spatio‐temporal and social inequalities perspective. Methods We conducted a mixed ecological study using death certificates from the Mortality Information System and hospital admissions from the ...
Anderson Fuentes Ferreira, Jorg Heukelbach, Eliana Amorim de Souza, Maria Aparecida Shikanai‐Yasuda, Lisandra Serra Damasceno, Terezinha do Menino Jesus Silva Leitão, Ziadir Francisco Coutinho, Helia Kawa, Milena Maria Alves Vasconcelos, Alberto Novaes Ramos Jr   +9 more
wiley   +1 more source

Association of caspase-1 polymorphisms with Chagas cardiomyopathy among individuals in Santa Cruz, Bolivia

Revista da Sociedade Brasileira de Medicina Tropical
INTRODUCTION: Trypanosoma cruzi (Tc) infection is usually acquired in childhood in endemic areas, leading to Chagas disease, which progresses to Chagas cardiomyopathy in 20-30% of infected individuals over decades.
Katherine Yih-Jia Fu, Roxana Zamudio, Jo Henderson-Frost, Alex Almuedo, Hannah Steinberg, Steven Joseph Clipman, Gustavo Duran, Rachel Marcus, Thomas Crawford, Daniel Alyesh, Rony Colanzi, Jorge Flores, Robert Hugh Gilman, Caryn Bern   +13 more
doaj   +1 more source

Clinical and echocardiographic predictors of mortality in chagasic cardiomyopathy - systematic review

Arquivos Brasileiros de Cardiologia, 2014
Diagnosis, prognosis and evaluation of death risk in Chagas cardiomyopathy still constitute a challenge due to the diversity of manifestations, which determine the importance of using echocardiography, tissue Doppler and biomarkers. To evaluate, within a
Clodoval de Barros Pereira Júnior, Brivaldo Markman Filho   +1 more
doaj   +1 more source

The Intersection of m6A Methylation and Immune Response in PCOS: A Bioinformatics Perspective

Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.
N6‐methyladenosine RNA methylation regulators are intricately linked with the development of polycystic ovary syndrome (PCOS) and may influence immune cell infiltration in affected individuals. This study enhances our understanding of the molecular interactions in PCOS and suggests potential biomarkers for diagnosis and targets for therapeutic ...
Wenting Xu, Lingli Shi, Aifang Lu, Lijuan Cui, Haiqing Qian, Jiahui Wang, Mengyu Tang, Lili Zhu, Lihong Wang   +8 more
wiley   +1 more source

Early Onset Heart Failure due to RBM20 Variant: A Case Report Emphasizing Genetic Diagnosis and Arrhythmic Risk Stratification

Clinical Case Reports, Volume 14, Issue 1, January 2026.
Transthoracic echocardiography demonstrating biventricular dilatation. Parasternal long‐ and short‐axis views and apical four‐ and two‐chamber views show marked left ventricular dilatation with increased end‐diastolic volume, associated with right ventricular dilatation.
Cristian Orlando Porras Bueno, Cesar Augusto Balaguera, Alejandro Mariño Correa, Edward Andrés Cáceres Méndez   +3 more
wiley   +1 more source

Pathogenesis of chronic Chagas cardiomyopathy: the role of coronary microvascular derangements

Revista da Sociedade Brasileira de Medicina Tropical, 2013
There is ample experimental and clinical evidence of functional and structural microvascular abnormalities occurring in patients with Chagas cardiomyopathy, possibly due to the inflammatory process and/or autonomic disturbances caused by Trypanosoma ...
Jose Antonio Marin-Neto, Marcus Vinicius Simoes, Anis Rassi Junior   +2 more
doaj   +1 more source