Results 51 to 60 of about 28,625 (273)

Regio‐ and Diastereoselective One‐pot Double Cascade Hybrid Formation/[3+3] Spirocyclization for the Synthesis of 3‐Spiropiperidines Under Phase Transfer Conditions

Advanced Synthesis &Catalysis, Volume 367, Issue 6, March 18, 2025.
Abstract Herein, we report an efficient approach to synthesizing hybrid 3‐spiropiperidine heterocycles that incorporate both 3‐isochromanone and 3‐isoindolinone units through a one‐pot, double cascade reaction facilitated by an economical K2CO3/TBAB catalytic system.
Antonia Di Mola, Mohammad Sadeq Mousavi, Lorenzo Simeone, Giovanni Pierri, Antonio Massa   +4 more
wiley   +1 more source

Novel Low‐Cytotoxic and Highly Efficient Type I Photoinitiators for Visible LED‐/Sunlight‐Induced Photopolymerization and High‐Precision 3D Printing

Angewandte Chemie, Volume 137, Issue 18, April 25, 2025.
This study develops new photoinitiators (PIs) for photopolymerization, combining high efficiency, low toxicity, and compatibility with 3D printing. The C5 compound, designed via molecular modeling, outperforms commercial PIs, improving initiation by 40–132 % under LED and sunlight.
Tong Gao, Zheng Liu, Jiansong Yin, Ji Feng, Céline Dietlin, Fabrice Morlet‐Savary, Michael Schmitt, Tatiana Petithory, Laurent Pieuchot, Jing Zhang, Frédéric Dumur, Jacques Lalevée, Pu Xiao   +12 more
wiley   +2 more sources

Identification of some chalcone analogues as potential antileishmanial agents: An integrated in vitro and in silico evaluation

Arabian Journal of Chemistry, 2022
Chalcones, either natural or synthetic, are known to exhibit various biological activities. The present study aimed to evaluate the in vitro and in silico activities of some chalcone analogues as potential antleishmanial agents via inhibition of the ...
Marwa S. Osman, Talal A. Awad, Shaza W. Shantier, Elrashied A. Garelnabi, Wadah Osman, Ramzi A. Mothana, Fahd A. Nasr, Rashid I. Elhag   +7 more
doaj  

Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies

Advanced Science, EarlyView.
Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu, Yao Liu, Zujun Que, Bin Luo, Yun Yang, Yan Li, Zhanxia Zhang, Jianhui Tian   +7 more
wiley   +1 more source

Flow Electroreductive Nickel‐Catalyzed Cyclopropanation of Alkenes Using gem‐Dichloroalkanes

Angewandte Chemie, Volume 137, Issue 15, April 7, 2025.
We report an efficient continuous‐flow electroreductive nickel‐catalyzed cyclopropanation of olefins using commercial gem‐dichloroalkanes. The reaction is tolerant to oxygen and moisture while displaying a broad functional group compatibility.
Morgan Regnier, Clara Vega, Dimitris I. Ioannou, Zhenyu Zhang, Timothy Noël   +4 more
wiley   +2 more sources

Evaluation and Optimization of the Anti-Melanogenic Activity of 1-(2-Cyclohexylmethoxy-6-hydroxy-phenyl)-3-(4-hydroxymethyl-phenyl)-propenone Derivatives

Molecules, 2019
The chemical modification and optimization of biologically active compounds are essential steps in the identification of promising lead compounds for drug development.
Byung-Hak Kim, Soo-Nam Hong, Sang-Kyu Ye, Jung-Youl Park   +3 more
doaj   +1 more source

Aging‐induced Alternation in the Gut Microbiota Impairs Host Antibacterial Defense

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Bacterial infections in older individuals often result in worse outcomes, but the mechanisms remain unclear. This study reveals that aging‐induced alterations in gut microbiota impair host antibacterial defense mechanisms, and exacerbate the consequences of bacterial infections.
Peng Gu, Rongjuan Wei, Ruofan Liu, Qin Yang, Yuxuan He, Jianbin Guan, Wenhao He, Jiaxin Li, Yunfei Zhao, Li Xie, Jie He, Qingling Guo, Jiajia Hu, Jingna Bao, Wandang Wang, Jiayin Guo, Zhenhua Zeng, Zhongqing Chen, Yong Jiang, Zhanguo Liu, Peng Chen   +20 more
wiley   +1 more source

Supramolecular Gels as Active Tools for Reaction Engineering

Angewandte Chemie, EarlyView.
The unique combination of environments within gels, self‐assembled from low‐molecular‐weight gelators, offers the ability to control reactivity in new ways, achieving unique reaction outcomes, leading to the emerging concept of supramolecular gels as nanoreactors. Smart chemical engineering methods enable the use of such gels to fabricate materials and
David K. Smith
wiley   +2 more sources

Trans-Chalcone Attenuates Pain and Inflammation in Experimental Acute Gout Arthritis in Mice

Frontiers in Pharmacology, 2018
Gouty arthritis is characterized by an intense inflammatory response to monosodium urate crystals (MSU), which induces severe pain and reduction in the life quality of patients.
Larissa Staurengo-Ferrari, Kenji W. Ruiz-Miyazawa, Felipe A. Pinho-Ribeiro, Victor Fattori, Tiago H. Zaninelli, Stephanie Badaro-Garcia, Sergio M. Borghi, Thacyana T. Carvalho, Jose C. Alves-Filho, Thiago M. Cunha, Fernando Q. Cunha, Rubia Casagrande, Waldiceu A. Verri   +12 more
doaj   +1 more source

N‐Heterocyclic Carbene Organocatalysis Enabled Modular Synthesis of Fluorinated Isoflavonoids to Suppress Proliferation and Migration in Breast Cancer Cells

Advanced Science, Volume 12, Issue 13, April 3, 2025.
An NHC‐catalyzed transformation is successfully developed to modularly synthesize novel fluorinated isoflavone derivatives under environmental‐friendly conditions. This approach represents an unprecedented organocatalytic 1,3,4‐trifunctionalization of 1,3‐enynes designed for the green synthesis of bioactive isoflavones in a single step.
Yan‐Qing Liu, Lei‐Lei Fu, Long‐Hai Hong, Xin‐Xin Kou, Xiang Zhang, Rong Zeng, Yong‐Qi Zhen, Bo Han, Jun‐Long Li   +8 more
wiley   +1 more source