Results 91 to 100 of about 10,225 (206)

A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer Progression

Molecular Carcinogenesis, Volume 65, Issue 4, Page 508-522, April 2026.
ABSTRACT Prostate cancer (PCa) is the second most common cancer and second leading cause of cancer death for American men. Chemoprevention by using phytochemicals offers a promising approach to improve outcomes due to their ability to act on cancer cell metabolism and growth while maintaining low toxicity profiles.
Rachel Clark, Achinto Saha, G. Lavender Hackman, Chelsea A. Friedman, Ruggiero Gorgoglione, Stefano Tiziani, John DiGiovanni   +6 more
wiley   +1 more source

Unveiling the Anticancer Properties of New Synthesized Alkoxy‐ and Methyl Thio‐Chalcone Derivatives

Natural Sciences, Volume 6, Issue 2, April 2026.
ABSTRACT Breast and cervical cancers are a serious problem and the leading cause of death in women in this decade. Chalcone is a promising compound with great potential for anticancer use. In this work, we synthesized six chalcone derivatives with alkoxy‐ and methylthio‐substituents through Claisen–Schmidt condensation at room temperature.
Nurcahyo Iman Prakoso, Taiki Umezawa, Dwiarso Rubiyanto, Azizah Zelia Kusumo, Fanny Septianingtyas, Muhamad Ikhsan Nurochman, Laras Kristianti, Salmahaminati, Pinus Jumaryatno, Minori Abe   +9 more
wiley   +1 more source

Multifaceted roles of BBX transcription factors: impacts on key agronomical traits and environmental resilience

New Phytologist, Volume 250, Issue 2, Page 762-787, April 2026.
Summary B‐box (BBX) proteins were initially characterized as transcription factors connecting light signaling to the regulation of flowering time and seedling photomorphogenesis. However, over the last decade, increasing evidence has shown that they integrate light and hormone signaling, modulating multiple physiological processes during plant life. In
Bruno Silvestre Lira, Juliene Moreira, Luciano Freschi, Magdalena Rossi   +3 more
wiley   +1 more source

Cobalt‐Salen Catalysed Hydration of Alkenes With Water: A Complementary Ionic Approach to the Mukaiyama Hydration

Advanced Synthesis &Catalysis, Volume 368, Issue 5, 3 March 2026.
A cobalt‐salen catalysed hydration of olefins with water is reported, resulting in Markovnikov alcohol products. The reaction proceeds rapidly under mild conditions and exhibits excellent functional group tolerance, supporting a wide range of styrenyl and non‐activated alkenes.
David G. Groves, Reece H. Hoogesteger, Balakumar Emayavaramban, Craig P. Johnston   +3 more
wiley   +1 more source

Structural and Interactional Analysis of the Flavonoid Pathway Proteins: Chalcone Synthase, Chalcone Isomerase and Chalcone Isomerase-like Protein

International Journal of Molecular Sciences
Chalcone synthase (CHS) and chalcone isomerase (CHI) catalyze the first two committed steps of the flavonoid pathway that plays a pivotal role in the growth and reproduction of land plants, including UV protection, pigmentation, symbiotic nitrogen fixation, and pathogen resistance.
Jacob A. Lewis, Eric P. Jacobo, Nathan Palmer, Wilfred Vermerris, Scott E. Sattler, James A Brozik, Gautam Sarath, ChulHee Kang   +7 more
openaire   +2 more sources

Antibacterial Activity of a Mouthwash Containing Plectranthus amboinicus (Lour.) Spreng Extract and Lippia sidoides Cham. Essential Oil

Chemistry &Biodiversity, Volume 23, Issue 3, March 2026.
Plant‐Based Antibacterial Mouthwash. ABSTRACT This study investigated the development of a mouthwash formulated with Plectranthus amboinicus leaf extract (PaEE) and Lippia sidoides leaf essential oil (LsOE), exploring their antibacterial potential.
Wilma Francisca da Silva, Carla de Fatima Alves Nonato, Débora Odília Duarte Leite, Fabiola Fernandes Galvão Rodrigues, Fazia Fernandes Galvão Rodrigues, Ana Cecília Calixto Donelardy, José Galberto Martins da Costa   +6 more
wiley   +1 more source

Exploring the Anti‐Diabetic Potential of Anthocyanins: From Biochemical Pathways to Human Trials

Chronic Diseases and Translational Medicine, Volume 12, Issue 1, Page 1-15, March 2026.
ABSTRACT Diabetes mellitus (DM) is a global health challenge with increasing prevalence rates, particularly in low‐ and middle‐income countries. Anthocyanins (ACs) are potential bioactive compounds found in various fruits and vegetables, attracting the attention of researchers due to their possible role in managing diabetes and its complications ...
Lakshay Panchal, Sangeeta Yadav, Akash Kumar, Tanbeer Kaur, Yashna Bawa, Sarvesh Rustagi, Rahul Mehra   +6 more
wiley   +1 more source

Resolution of a Chiral β‐Aminoketone via Diastereomeric Salt Formation: From Experimental Evidence to Molecular‐Level Insights Into Solution‐Phase Clusters

Chirality, Volume 38, Issue 3, March 2026.
Subtle but significant differences between the heterochiral and homochiral salts during the prenucleation stage, revealed by molecular simulations, are related to the enantiomeric separation of a β‐aminoketone through the precipitation of its corresponding diastereomeric salts. ABSTRACT The classical diastereomeric salt resolution approach was employed
Caterina Momoli, Laura Palombi, Isabella Daidone, Erica Scarel, Massimiliano Aschi   +4 more
wiley   +1 more source

An Overview of Anticancer Chalcones with Apoptosis Inducing Activity

Journal of Mazandaran University of Medical Sciences, 2017
Cancer is a complex and life-threatening disease involving uncontrollable cell proliferation, evading apoptosis, and metastasis. Despite recent developments in cancer chemotherapy, there are no effective broad spectrum anticancer agents that could ...
Hassan Mirzaei, Masoud Keighobadi, Saeed Emami   +2 more
doaj  

Cardamonin Commands the Colonic Metabolite Columbianetin Acetate to Compete Against LPS in Binding HMGB1 in the Kidney, Preventing Lipopolysaccharide‐Induced Renal Tubular Pyroptosis

Food Frontiers, Volume 7, Issue 2, March 2026.
Cardamonin upregulate sd the intestinal metabolite columbianetin acetate, which competitively bound HMGB1 to prevent LPS‐induced renal tubular cell pyroptosis (the figure is created with BioRender). ABSTRACT Sepsis‐associated acute kidney injury (SA‐AKI) results in high mortality due to the lack of effective interventions. The current study reports the
Zihui Zhou, Xuechun Sun, Jian Zhou, Huali Meng, Pengfei Fan, Yufeng Chu, Hao Wu   +6 more
wiley   +1 more source