Results 61 to 70 of about 10,225 (206)

Design and Synthesis of Pyridyl and 2-Hydroxyphenyl Chalcones with Antitubercular Activity

Molecules
A focussed library of pyridyl and 2-hydroxyphenyl chalcones were synthesized and tested for growth inhibitory activity against Mycobacterium tuberculosis H37Rv, and normal and cancer breast cell lines.
Kelphina Aziafor, Ketan Ruparelia, Brandon Moulds, Mire Zloh, Tanya Parish, Federico Brucoli   +5 more
doaj   +1 more source

Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression

Cancer Science, EarlyView.
Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley   +1 more source

Ultrasound Assisted Synthesis of Chalcones as Green Corrosion Inhibitors for Mild Steel in 1M Hydrochloric Solution

International Journal of Electrochemical Science, 2014
The three chalcones namely (E)-3-(4-hydroxyphenyl)-N-phenylacrylamide (INH-1), (E)-3- (4dimethylamino)phenyl)-N-phenylacrylamide (INH-2) and (E) -3-(4-hydroxy-3-methoxyphenyl)-N- phenylacrylamide (INH-3) were synthesized and their corrosion inhibition ...
Pooja Singh, M.A. Quraishi, E.E. Ebenso, Chandra Bhan Verma   +3 more
doaj   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

The multidimensional regulation roles and mechanisms of calcium in fruit quality

Journal of Integrative Plant Biology, EarlyView.
This review explores how calcium signaling molecule integrates plant hormones, environmental cues, and developmental signals to influence external fruit traits, internal nutritional properties, and physiological disorders. ABSTRACT Calcium (Ca2+), a dual‐functional mineral that serves both as an essential structural factor and a signaling molecule ...
Fei Jiang, Siyang Gao, Mengdi Li, Zeqi Zhao, Chengwei Yang, Ji‐Hong Liu, Chunlong Li   +6 more
wiley   +1 more source

Antimicrobial Evaluation and Synthesis of Some Phenylpyrazolo benzothiazolo quinoxaline Derivatives

E-Journal of Chemistry, 2009
2,3-Diphenyl quinoxaline (SI) was fused with 2-amino benzothiazoles (SII) by a methylene bridge, which was then allowed for acetylation. The acetylated product (SIV) was made to react with different aromatic aldehydes to give chalcones (SV1-SV5 ...
CH. Sridevi, K. Balaji, A. Naidu, R. Sudhakaran   +3 more
doaj   +1 more source

Synthesis, Antioxidant and Antimicrobial Activities of a Novel Series of Chalcones, Pyrazolic Chalcones, and Allylic Chalcones

Pharmacology & Pharmacy, 2011
A new series of chalcones (4a-c) and allylicchalcones (11a-b) have been prepared by the Claisen-Schmidt condensation. A novel series of pyrazolicchalcones (5a-c) have been synthesized by the reaction of respective chalcones (4a-c) and hydrazine hydrate.
Tan Nhut Doan, Dao Thanh Tran
openaire   +2 more sources

Engineering of the Flavone Rutinoside Biosynthetic Pathway Enables Production of Diosmin, a Venoactive Compound in Solanum lycopersicum and Nicotiana tabacum

Plant Biotechnology Journal, EarlyView.
ABSTRACT Diosmin is often used as a dietary supplement, and it is sometimes used to make phlebotropic drugs for venous diseases. Traditionally, diosmin is obtained by the dehydrogenation of the flavanone glycoside hesperidin through chemical semisynthesis.
Qianle Zhang, Qingwen Wu, Wenjing Shi, Yinai Deng, Ruoting Zhan, Dongming Ma   +5 more
wiley   +1 more source

Convergent Evolution and De Novo Reconstitution of Apiin Biosynthesis

Plant Biotechnology Journal, EarlyView.
ABSTRACT Apiin, an active flavonoid apioside, occurs in phylogenetically distant plants, such as parsley and chilli pepper (Capsicum annuum L.). Its sporadic distribution suggests the existence of convergent apiin biosynthesis; however, the molecular mechanisms underlying this convergence remain unclear.
Zhen Xu, Zheng‐Shuang Zhu, Hai‐Zhu Jia, Jian‐Qiang Kong   +3 more
wiley   +1 more source

Genetic Basis of UV Bullseye Size Variations in Turnip Rape (Brassica rapa subsp. oleifera)

Plant Biotechnology Journal, EarlyView.
ABSTRACT Floral ultraviolet (UV) patterns are visible to bee pollinators and can affect crop yields by impacting pollinator visitation. However, the mechanisms underlying the intraspecific variations of UV bullseye size remain largely unknown. We analyse the ecological consequences and genetic basis of floral UV bullseye size variation in an important ...
Zhi‐Li Zhou, Yu Zhang, Li‐Ling Jiang, An‐Ning Li, Guo‐Peng Zhang, Ming‐Liu Yang, Zhi‐Qiang Zhang, Dong‐Rui Jia, Bin Tian, Xu‐Dong Sun, Yong‐Ping Yang, Yuan‐Wen Duan   +11 more
wiley   +1 more source