Results 101 to 110 of about 2,639,548 (308)
Molecular Oncology, EarlyView.Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen +11 more
wiley +1 more source
PlantsThe low nutrient content of soil in desert ecosystems results in unique physiological and ecological characteristics of plants under long-term water and nutrient stress, which is the basis for the productivity and stability maintenance of the desert ...
Yunhao Zhao +3 more
doaj +1 more source
Direction and Intensity of Technical Change: a Micro Model [PDF]
This paper develops a growth model combining elements of endogenous growth and induced innovation literatures. In a standard induced innovation model firms select at no cost innovations from an innovation possibilities frontier describing the trade-off ...
Luca Zamparelli
core
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Towards a Theory of Climate Innovation - A Model Framework for Analyzing Drivers and Determinants [PDF]
Climate change, including its possible causes and consequences, is one of the most controversial and intensely discussed topics of our time. However, European businesses nowadays are less affected by the direct effects of climate change than by its ...
Wilfried Ehrenfeld
core
Innovation and institutional change : the transition to a sustainable electricity system [PDF]
, 2005 The aim of this book is to specify this perspective by analysing patterns of change in the electricity system. Scientifically, the relevance of the book is in its analysis and explanation of fundamental processes of change, a topic relevant for a range ...
Hofman, Peter Silvester
core +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Recherches en ÉducationThe article aims at the ecosystem description of the 48 schools in the network of alternative public schools of Quebec (RÉPAQ), based on the positive stories of the experiences of former students and current actors. To understand their common functioning
Philippe Chaubet +4 more
doaj +1 more source
Immigrant Workers and Technological Change in U.S. Agriculture: A Profit Maximization Approach of Induced Innovation [PDF]
This paper analyzes changes in U.S. agricultural technology during 1960-1999, emphasizing the role of immigrant workers on farm mechanization. The rates and directions of biased technological change based on the induced innovation theory are compared ...
Emerson, Robert D. +1 more
core +1 more source