Editorial Note: Expression of Concern: Chaperone-mediated autophagy targets IFNAR1 for lysosomal degradation in free fatty acid treated HCV cell culture. [PDF]
PLoS OnePLOS One Editors.
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Ginkgolide C alleviates atherosclerosis by activating LAMP-2A to enhance chaperone-mediated autophagy and promote NLRP3 inflammasome degradation. [PDF]
Front PharmacolZhang R.
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Chaperone-mediated autophagy contributes to chromosomal stability by controlling TTC28 degradation. [PDF]
AutophagyZhang G, Tian W, Deng D.
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TMEM59 deficiency activates chaperone-mediated autophagy and ameliorates disease-like pathologies in tauopathy model mice. [PDF]
Alzheimers DementZheng N +12 more
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The coming of age of chaperone-mediated autophagy [PDF]
Nature Reviews Molecular Cell Biology, 2018 Chaperone-mediated autophagy (CMA) was the first studied process that indicated that degradation of intracellular components by the lysosome can be selective - a concept that is now well accepted for other forms of autophagy. Lysosomes can degrade cellular cytosol in a nonspecific manner but can also discriminate what to target for degradation with the
Ana María Cuervo, Susmita Kaushik
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Protein homeostasis is essential for maintaining cell survival. Protein synthesis and degradation coordinately regulate protein homeostasis. Chaperone-mediated autophagy (CMA) was the first lysosomal process to be discovered by which intracellular components are selectively degraded. This process involves the recognition of the substrate, the unfolding
Qian, Yang, Ronglin, Wang, Lin, Zhu
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Interplay of LRRK2 with chaperone-mediated autophagy [PDF]
Nature Neuroscience, 2013 Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common cause of familial Parkinson's disease. We found LRRK2 to be degraded in lysosomes by chaperone-mediated autophagy (CMA), whereas the most common pathogenic mutant form of LRRK2, G2019S, was poorly degraded by this pathway.
David Sulzer +2 more
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Mechanisms of chaperone-mediated autophagy
The International Journal of Biochemistry & Cell Biology, 2004Chaperone-mediated autophagy is one of several lysosomal pathways of proteolysis. This pathway is activated by physiological stresses such as prolonged starvation. Cytosolic proteins with particular peptide sequence motifs are recognized by a complex of molecular chaperones and delivered to lysosomes.
Amy E, Majeski, J Fred, Dice
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Pathophysiology of chaperone-mediated autophagy
The International Journal of Biochemistry & Cell Biology, 2004In contrast to the classically described "in bulk" lysosomal degradation, the first evidence for selective degradation of cytosolic proteins in lysosomes was presented more than 20 years ago. Throughout this time, we have gained a better understanding about this process, now known as chaperone-mediated autophagy (CMA).
Ashish, Massey +2 more
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Degradation of AF1Q by chaperone-mediated autophagy
Experimental Cell Research, 2014AF1Q, a mixed lineage leukemia gene fusion partner, is identified as a poor prognostic biomarker for pediatric acute myeloid leukemia (AML), adult AML with normal cytogenetic and adult myelodysplastic syndrome. AF1Q is highly regulated during hematopoietic progenitor differentiation and development but its regulatory mechanism has not been defined ...
Peng, Li +8 more
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