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Dysfunction of chaperone-mediated autophagy in human diseases
Molecular and Cellular Biochemistry, 2021Chaperone-mediated autophagy (CMA), one of the degradation pathways of proteins, is highly selective to substrates that have KFERQ-like motif. In this process, the substrate proteins are first recognized by the chaperone protein, heat shock cognate protein 70 (Hsc70), then delivered to lysosomal membrane surface where the single-span lysosomal receptor,
Zhaozhong Liao +7 more
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Chaperone‐Mediated Autophagy in Aging and Disease
2006Different mechanisms target intracellular components for their degradation into lysosomes through what is known as autophagy. In mammals, three main forms of autophagy have been described: macroautophagy, microautophagy, and chaperone-mediated autophagy (CMA).
Ashish C, Massey +2 more
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Methods to Study Chaperone-Mediated Autophagy
2017Chaperone-mediated autophagy (CMA), a selective form of degradation of cytosolic proteins in lysosomes, contributes to maintenance of proteostasis and to the cellular adaptation to stress. CMA substrates are selectively recognized and delivered by a cytosolic chaperone to the lysosomal surface, where, upon unfolding, they are internalized through a ...
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Deficient Chaperone-Mediated Autophagy Promotes Inflammation and Atherosclerosis
Circulation Research, 2021Chungang Zhai +2 more
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Chaperone-mediated autophagy sustains haematopoietic stem-cell function
Nature, 2021Evripidis Gavathiotis +2 more
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PTEN is both an activator and a substrate of chaperone-mediated autophagy
Journal of Cell Biology, 2023Mary Skinner, David B. Lombard
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Chaperone-mediated autophagy: Dice's 'wild' idea about lysosomal selectivity
Nature Reviews Molecular Cell Biology, 2011Ana María Cuervo
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