Results 91 to 100 of about 226,086 (342)

Notch2 Directs aTreg Cell Fate toward Immunoregulation or Inflammatory Pyroptosis

Advanced Science, EarlyView.
Schematic illustration showing that the Notch2 intracellular domain (NICD2) facilitates pyroptosis resistance in activated Tregs through the RREB1/Foxo1 signaling pathway. In addition, Notch2‐mediated pyroptosis resistance in activated Tregs promotes immunoregulatory capacity, thereby attenuating Th2‐driven inflammatory responses in allergic rhinitis ...
Yue‐Long Qiao, Shan Xu, You Zou, Rui Yang, Han Zheng, Jia‐Yu Liu, Hui‐Ming Fan, Yuan‐Yuan Zhang, Yong‐Gang Kong, Wo‐Er Jiao, Shi‐Ming Chen   +10 more
wiley   +1 more source

Regulatory coiled-coil domains promote head-to-head assemblies of AAA+ chaperones essential for tunable activity control

eLife, 2017
Ring-forming AAA+ chaperones exert ATP-fueled substrate unfolding by threading through a central pore. This activity is potentially harmful requiring mechanisms for tight repression and substrate-specific activation.
Marta Carroni, Kamila B Franke, Michael Maurer, Jasmin Jäger, Ingo Hantke, Felix Gloge, Daniela Linder, Sebastian Gremer, Kürşad Turgay, Bernd Bukau, Axel Mogk   +10 more
doaj   +1 more source

Review for "The non‐prion SUP35 preexists in large chaperone‐containing molecular complexes"

, 2021

openalex   +1 more source

#5441 EVIDENCE THAT CHAPERONE 4-PBA TREATMENT ALLEVIATES THE RENAL PHENOTYPE IN ALPORT SYNDROME MOUSE MODELS [PDF]

, 2023
Pavlos Ioannou, Christoforos Odiatis, Kyriaki I. Antoniadou, Myrtani Pieri, Gregory Papagregoriou, Apostolos Malatras, Martina Samiotaki, Matija Horaček, Danica Galešić Ljubanović, Kostas Stylianou, Constantinos Deltas   +10 more
openalex   +1 more source

Chaperone-client interactions: Non-specificity engenders multifunctionality

Journal of Biological Chemistry, 2017
Here, we provide an overview of the different mechanisms whereby three different chaperones, Spy, Hsp70, and Hsp60, interact with folding proteins, and we discuss how these chaperones may guide the folding process. Available evidence suggests that even a
P. Koldewey, S. Horowitz, J. Bardwell
semanticscholar   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Decreased Protein Quality Control Promotes the Cognitive Dysfunction Associated With Aging and Environmental Insults

Frontiers in Neuroscience, 2018
Background: Most neurodegenerative diseases are sporadic and develop with age. Degenerative neural tissues often contain intra- and extracellular protein aggregates, suggesting that the proteostasis network that combats protein misfolding could be ...
Hisayo Jin, Mari Komita, Tomohiko Aoe
doaj   +1 more source

Ambroxol chaperone therapy for neuronopathic Gaucher disease: A pilot study

Annals of Clinical and Translational Neurology, 2016
Gaucher disease (GD) is a lysosomal storage disease characterized by a deficiency of glucocerebrosidase. Although enzyme‐replacement and substrate‐reduction therapies are available, their efficacies in treating the neurological manifestations of GD are ...
A. Narita, K. Shirai, Shinji Itamura, A. Matsuda, A. Ishihara, Kumi Matsushita, C. Fukuda, Norika Kubota, R. Takayama, H. Shigematsu, Anri Hayashi, T. Kumada, K. Yuge, Yoriko Watanabe, Saori Kosugi, H. Nishida, Yukiko Kimura, Yusuke Endo, K. Higaki, E. Nanba, Y. Nishimura, A. Tamasaki, Masami Togawa, Yoshiaki Saito, Y. Maegaki, K. Ohno, Yoshiyuki Suzuki   +26 more
semanticscholar   +1 more source

Microglial Fkbp5 Impairs Post‐Stroke Vascular Integrity and Regeneration by Promoting Yap1‐Mediated Glycolysis and Oxidative Phosphorylation

Advanced Science, EarlyView.
A post‐stroke perivascular niche of microglia characterized by low expression of M2 markers and elevated glycolysis, oxidative phosphorylation (OXPHOS), and phagocytic activity is identified, which is termed stroke‐activated vascular‐associated microglia (stroke‐VAM).
Yanan Li, Yanmei Qiu, Yunlei Yang, Yanhao Wei, Haokun Peng, Longhai Zeng, Pengcheng Li, Rentang Bi, Bo Hu   +8 more
wiley   +1 more source

Modulating Purothionin Accumulation and Signal Peptide Cleavage Fine‐Tunes Wheat Flour Gluten Properties to Improve Cookie‐Making Quality

Advanced Science, EarlyView.
Dual genetic strategies for improving wheat processing quality by regulating purothionin accumulation to modulate gluten quantity and quality. The first strategy involves targeting signal peptide (SP) cleavage sites (e.g., through mutation) to indirectly reduce gluten content, thereby disrupting gluten network formation.
Yijie Liu, Siyuan Chang, Zhaoheng Zhang, Tianqi Kang, Mingde Liu, Yuan Zong, Fei Ni, Yinguang Bao, Ruijie Zhang, Xiaobang Zhang, Jinkun Du, Mingming Xin, Zhaorong Hu, Jie Liu, Zhongfu Ni, Qixin Sun, Yingyin Yao   +16 more
wiley   +1 more source