Results 61 to 70 of about 285,190 (188)
Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β. [PDF]
, 2016 Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1.
Chen, Shu-Ching +7 more
core +1 more source
Metabolites, 2022 The importance of the proprotein convertase subtilisin/kexin type-9 (PCSK9) gene was quickly recognized by the scientific community as the third locus for familial hypercholesterolemia. By promoting the degradation of the low-density lipoprotein receptor
Paul F. Lebeau +4 more
doaj +1 more source
Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 [PDF]
, 2017 We thank Zhen-Yuan Lin for help in the preparation of the AP-MS samples, and Cathy Collins for technical assistance. MDL is supported by a Sir Henry Wellcome Postdoctoral Fellowship (Wellcome Trust 096072), LEC is supported by a Canada Research Chair in ...
Bohovych, Iryna +7 more
core +4 more sources
Co-crystalization and in vitro biological characterization of 5-Aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 inhibitors [PDF]
, 2012 A potential therapeutic strategy for targeting cancer that has gained much interest is the inhibition of the ATP binding and ATPase activity of the molecular chaperone Hsp90.
Chrisostomos Prodromou +7 more
core +6 more sources
, 2005 We investigate the translocation of a stiff polymer consisting of M monomers through a nanopore in a membrane, in the presence of binding particles (chaperones) that bind onto the polymer, and partially prevent backsliding of the polymer through the pore.
Alberts B +23 more
core +2 more sources
Assembly and beyond – The structure and functions of chaperones of the proteasome
Biomedical Research Journal, 2016 The 26S proteasome is the major protease machinery in eukaryotic cells responsible for spatio-temporally regulated turnover of the proteome and therefore critical to the maintenance of homeostasis.
Prasanna Venkatraman
doaj +1 more source
Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases
Frontiers in Neuroscience, 2019 Alzheimer’s, Huntington’s, and Parkinson’s are devastating neurodegenerative diseases that are prevalent in the aging population. Patient care costs continue to rise each year, because there is currently no cure or disease modifying treatments for these ...
Liam Gracia +3 more
doaj +1 more source
Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
Biology, 2013 Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit ...
Gabriel Waksman, James Lillington
doaj +1 more source
CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease
CellsThe development of cell-type-specific dendritic arbors is integral to the proper functioning of neurons within their circuit networks. In this study, we examine the regulatory relationship between the cytosolic chaperonin CCT, key insulin pathway genes ...
Erin N. Lottes +8 more
doaj +1 more source
Biomolecular Concepts, 2016 Despite remarkable advances in synthetic biology, the fact remains that it takes a living cell to make a new living cell. The information encoded in the genome is necessary to direct assembly of all cellular components, but it may not be sufficient. Some
McMurray Michael A.
doaj +1 more source