Results 71 to 80 of about 226,086 (342)
Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili
Biology, 2013 Type I and P pili are chaperone-usher pili of uropathogenic Escherichia coli, which allow bacteria to adhere to host cell receptors. Pilus formation and secretion are orchestrated by two accessory proteins, a chaperone, which catalyses pilus subunit ...
Gabriel Waksman, James Lillington
doaj +1 more source
Dynamic control of Hsf1 during heat shock by a chaperone switch and phosphorylation
eLife, 2016 Heat shock factor (Hsf1) regulates the expression of molecular chaperones to maintain protein homeostasis. Despite its central role in stress resistance, disease and aging, the mechanisms that control Hsf1 activity remain unresolved. Here we show that in
Xu Zheng +6 more
semanticscholar +1 more source
Advanced Healthcare Materials, EarlyView.Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji +7 more
wiley +1 more source
CCT and Cullin1 Regulate the TORC1 Pathway to Promote Dendritic Arborization in Health and Disease
CellsThe development of cell-type-specific dendritic arbors is integral to the proper functioning of neurons within their circuit networks. In this study, we examine the regulatory relationship between the cytosolic chaperonin CCT, key insulin pathway genes ...
Erin N. Lottes +8 more
doaj +1 more source
Biomolecular Concepts, 2016 Despite remarkable advances in synthetic biology, the fact remains that it takes a living cell to make a new living cell. The information encoded in the genome is necessary to direct assembly of all cellular components, but it may not be sufficient. Some
McMurray Michael A.
doaj +1 more source
Cells, 2018 Proteostasis is of vital importance for cellular function and it is challenged upon exposure to acute or chronic insults during neurodegeneration and aging.
Andreas Kern +3 more
doaj +1 more source
Inhibitors and chemical probes for molecular chaperone networks
Journal of Biological Chemistry, 2018 The molecular chaperones are central mediators of protein homeostasis. In that role, they engage in widespread protein–protein interactions (PPIs) with each other and with their “client” proteins.
J. Gestwicki, H. Shao
semanticscholar +1 more source
Advanced Sensor Research, EarlyView.This Review focuses on assessing and providing perspective on the field of rationally‐designed optical sensors constructed with single‐walled carbon nanotubes. The literature is reviewed and evaluated for SWCNT‐based sensors constructed with biomolecular recognition elements, including proteins, peptides, and oligonucleotides, as well as their methods ...
Amelia K. Ryan +4 more
wiley +1 more source
Advanced Science, EarlyView.In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou +10 more
wiley +1 more source
ZNRD2 Mediated Nucleoprotein Aggregation Impairs Respiratory Syncytial Virus Replication
Advanced Science, EarlyView.During RSV infection, nucleoprotein (N) forms RNA‐bound oligomers. The host protein ZNRD2 binds to these oligomers, promoting their transition into insoluble aggregates. These aggregates simultaneously sequester functional N to restrict viral production and disrupt chaperonin assembly quality control by interfering with ZNRD2's role as an adaptor ...
Haiwu Zhou +8 more
wiley +1 more source