Results 91 to 100 of about 183,487 (307)

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Extracellular Hsp72 concentration relates to a minimum endogenous criteria during acute exercise-heat exposure [PDF]

, 2013
Extracellular heat-shock protein 72 (eHsp72) concentration increases during exercise-heat stress when conditions elicit physiological strain. Differences in severity of environmental and exercise stimuli have elicited varied response to stress.
A Asea, A Asea, A Asea, A Asea, A Burton, AG Pockley, Alex Dennis, AM Watkins, AP Gagge, AT Garrett, AT Garrett, AT Garrett, B Drust, B Nielsen, D Gagnon, DB Dill, DOF Canada, DS Moran, DS Moran, E Fehrenbach, E Fehrenbach, E Giraldo, E Ortega, EM Winter, F Amorim, FDC Magalhães, FT Amorim, G Borg, G Multhoff, GA Selkirk, GA Selkirk, GI Lancaster, GI Lancaster, GI Lancaster, HC Marshall, HH Kampinga, J Campisi, JD Johnson, JD Périard, JP McClung, JV Durnin, K Anbarasi, K Ogawa, KD Singleton, L Taylor, L Taylor, L Taylor, L Taylor, LA Mizzen, LB Rowell, Lee Taylor, LL Hom, M Fleshner, M Iguchi, M Whitham, M Whitham, MA Febbraio, ME Sandström, ME Sandström, MN Sawka, Neil S. Maxwell, Oliver R. Gibson, P-Z Lu, PA Ruell, Peter W. Watt, PM Yamada, R Duffield, R Morimoto, R Njemini, RC Walsh, RJ Maughan, RW Hubbard, S Lorenzo, S Lorenzo, SDR Galloway, SG Rhind, SN Cheuvront, Tony Parfitt, WE Siri, WJ Welch, Y Ogura, Y Oishi   +81 more
core   +1 more source

Chaperone-assisted translocation [PDF]

Physical Biology, 2004
24 pages, 3 figures, LaTeX (IOP class file)
Ambjørnsson, T, Metzler, R
openaire   +3 more sources

Engineering of Glioblastoma‐Derived Biomimetic Vesicles and Their Structural and Molecular Features

Advanced Healthcare Materials, EarlyView.
ABSTRACT Biomimetic nanosystems and vesicles have arisen as a novel approach to design vesicular transport systems with diverse therapeutic potential. The ‘biomimetic’ strategy involves the integration of cell membrane components into lipid bilayers, conferring them with biological properties originating from the cell of origin. Until now, most studies
Noelia Hernández‐Lobato, Hanan Abumanhal‐Masarweh, Martí de Cabo, Pablo Guerra, Marilena Hadjidemetriou, Neus Lozano, Kostas Kostarelos   +6 more
wiley   +1 more source

Cotranslational folding of proteins on the ribosome.

, 2020
Many proteins in the cell fold cotranslationally within the restricted space of the polypeptide exit tunnel or at the surface of the ribosome. A growing body of evidence suggests that the ribosome can alter the folding trajectory in many different ways ...
Liutkute, M., Rodnina, M., Samatova, E.
core   +1 more source

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease [PDF]

, 2008
Prion diseases are fatal, transmissible, neurodegenerative diseases caused by the misfolding of the prion protein (PrP). At present, the molecular pathways underlying prion-mediated neurotoxicity are largely unknown.
Aguzzi, Adriano, Borkowski, Andrew W., Heppner, Frank L., Hutter, Gregor, Jackson, Walter S., King, Oliver D., Lindquist, Susan, Raymond, Gregory J., Steele, Andrew D.   +8 more
core   +3 more sources

QBP1 Peptide as a Potential Anti‐Amyloidogenic Therapy for Type 2 Diabetes: An In Vitro Study

Advanced Science, EarlyView.
The anti‐amyloidogenic peptide QBP1 effectively halts human islet amyloid polypeptide (hIAPP) aggregation, preventing the formation of toxic β‐structured intermediates. Through a combination of biophysical assays, molecular dynamics, and cell‐based studies, QBP1 is shown to preserve β‐cell viability and metabolic homeostasis, positioning it as a ...
María M. Tejero‐Ojeda, Ada Bernaus Vives, Michał Wojciechowski, Dinh Quoc Huy Pham, Mateusz Chwastyk, Mario Vallejo, Anna Novials, Douglas V. Laurents, Mariano Carrión‐Vázquez   +8 more
wiley   +1 more source

Chaperoning the Mononegavirales: Current Knowledge and Future Directions

Viruses, 2018
The order Mononegavirales harbors numerous viruses of significant relevance to human health, including both established and emerging infections. Currently, vaccines are only available for a small subset of these viruses, and antiviral therapies remain ...
Victor Latorre, Florian Mattenberger, Ron Geller   +2 more
doaj   +1 more source

The ins and outs of metal homeostasis by the root nodule actinobacterium Frankia [PDF]

, 2014
Background: Frankia are actinobacteria that form a symbiotic nitrogen-fixing association with actinorhizal plants, and play a significant role in actinorhizal plant colonization of metal contaminated areas.
Furnholm, Teal R., Tisa, Louis S.
core   +2 more sources

Targeting the PGRN‐BMP Lysosomal Axis With NPs@PGRN Reverses Immunometabolic Dysfunction in Chronic Septic Arthritis

Advanced Science, EarlyView.
Chronic septic arthritis involves intracellular bacterial persistence and lipid‐immune crosstalk via the PGRN‐BMP lysosomal axis. A dual‐targeting nanoparticle system (NPs@PGRN) restores lysosomal bactericidal function, reduces bacterial burden, and reprograms macrophage immunity, offering a novel therapeutic strategy. ABSTRACT Chronic septic arthritis,
Congsun Li, Jiaqi Fan, Tao Sun, Wushi Cui, Jiaxuan Zou, Weinan Yang, Liang Chen, Jian Xiao, Shicheng Wang, Tao Zhang, Jianqiao Hong, An Liu, Haobo Wu   +12 more
wiley   +1 more source