Results 31 to 40 of about 184,458 (283)

Structural and functional characterization of Pseudomonas aeruginosa CupB chaperones [PDF]

, 2010
Pseudomonas aeruginosa, an important human pathogen, is estimated to be responsible for,10% of nosocomial infections worldwide. The pathogenesis of P. aeruginosa starts from its colonization in the damaged tissue or medical devices (e. g.
A Filloux, A Zavialov, Alain Filloux, AV Zavialov, CCP4, D Choudhury, Dipshikha Chakravortty, DJ Hassett, E Chorell, ET Saulino, F Jacob-Dubuisson, FG Sauer, FG Sauer, G Waksman, Gabriel Waksman, GP Bodey, Guoyu Meng, H Hodak, H Remaut, I Vallet, J Mazar, J Tommassen, JG Bann, JL Veesenmeyer, JR Govan, JS Pinkner, JW St Geme 3rd, KW Dodson, MD Winn, MJ Kuehn, N Mesaros, P Watnick, R Fronzes, RA Engh, RA Laskowski, Rui Wang, S Ruer, S Ruer, TJ Knowles, WL DeLano, Xun Cai   +40 more
core   +8 more sources

Cellular Chaperones As Therapeutic Targets in ALS to Restore Protein Homeostasis and Improve Cellular Function

Frontiers in Molecular Neuroscience, 2017
Heat shock proteins (Hsps) are ubiquitously expressed chaperone proteins that enable cells to cope with environmental stresses that cause misfolding and denaturation of proteins.
Bernadett Kalmar, Linda Greensmith, Linda Greensmith   +2 more
doaj   +1 more source

Hsp70 and Hsp40 inhibit an inter-domain interaction necessary for transcriptional activity in the androgen receptor. [PDF]

, 2019
Molecular chaperones such as Hsp40 and Hsp70 hold the androgen receptor (AR) in an inactive conformation. They are released in the presence of androgens, enabling transactivation and causing the receptor to become aggregation-prone.
Banduseela, Varuna C, Brun-Heath, Isabelle, Chiesa, Giulio, Di Sanza, Claudio, Eftekharzadeh, Bahareh, Felli, Isabella C, García, Jesús, Gestwicki, Jason E, Giorgetti, Elisa, Lieberman, Andrew P, Marin-Argany, Marta, Martínez-Cristóbal, Paula, Nath, Samir R, Nebreda, Ángel R, Pierattelli, Roberta, Rauch, Jennifer N, Salvatella, Xavier, Schwarz, Daniel MC, Shao, Hao, Yu, Zhigang   +19 more
core   +2 more sources

Autophagic and Proteasomal Mediated Removal of Mutant Androgen Receptor in Muscle Models of Spinal and Bulbar Muscular Atrophy

Frontiers in Endocrinology, 2019
Spinal and bulbar muscular atrophy (SBMA) is an X-linked motoneuron disease (MND) caused by a mutant androgen receptor (AR) containing an elongated polyglutamine (polyQ) tract. ARpolyQ toxicity is triggered by androgenic AR ligands, which induce aberrant
Maria Elena Cicardi, Riccardo Cristofani, Valeria Crippa, Veronica Ferrari, Barbara Tedesco, Elena Casarotto, Marta Chierichetti, Mariarita Galbiati, Margherita Piccolella, Elio Messi, Serena Carra, Maria Pennuto, Maria Pennuto, Maria Pennuto, Paola Rusmini, Angelo Poletti, Angelo Poletti   +16 more
doaj   +1 more source

Hsp70 and Hsp110 Chaperones Promote Early Steps of Proteasome Assembly

Biomolecules, 2022
Whereas assembly of the 20S proteasome core particle (CP) in prokaryotes apparently occurs spontaneously, the efficiency of this process in eukaryotes relies on the dedicated assembly chaperones Ump1, Pba1-Pba2, and Pba3-Pba4.
Ana C. Matias, Joao Matos, R. Jürgen Dohmen, Paula C. Ramos   +3 more
doaj   +1 more source

Extracellular Chaperones

, 2010
The maintenance of the levels and correct folding state of proteins (proteostasis) is a fundamental prerequisite for life. Life has evolved complex mechanisms to maintain proteostasis and many of these that operate inside cells are now well understood.
Dabbs, Rebecca A, Wyatt, Amy R, Yerbury, Justin J, Ecroyd, Heath, Wilson, Mark R   +4 more
openaire   +5 more sources

Paradigm Shift in Drug Re-purposing From Phenalenone to Phenaleno-Furanone to Combat Multi-Drug Resistant Salmonella enterica Serovar Typhi

Frontiers in Cellular and Infection Microbiology, 2018
Over recent years, typhoid fever has gained increasing attention with several cases reporting treatment failure due to multidrug resistant (MDR) strains of Salmonella enterica serovar Typhi.
Shama Mujawar, Derek Gatherer, Chandrajit Lahiri   +2 more
doaj   +1 more source

DnaJC7 specifically regulates tau seeding

eLife, 2023
Neurodegenerative tauopathies are caused by accumulation of toxic tau protein assemblies. This appears to involve template-based seeding events, whereby tau monomer changes conformation and is recruited to a growing aggregate.
Valerie Ann Perez, David W Sanders, Ayde Mendoza-Oliva, Barbara Elena Stopschinski, Vishruth Mullapudi, Charles L White, Lukasz A Joachimiak, Marc I Diamond   +7 more
doaj   +1 more source

Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response

mSystems, 2021
Dynamical properties of gene regulatory networks are tuned to ensure bacterial survival. In mycobacteria, the MprAB-σE network responds to the presence of stressors, such as surfactants that cause surface stress.
Satyajit D. Rao, Pratik Datta, Maria Laura Gennaro, Oleg A. Igoshin   +3 more
doaj   +1 more source

Myelin pathology: Involvement of molecular chaperones and the promise of chaperonotherapy [PDF]

, 2019
The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Cappello F., Conway De Macario E., Macario A. J. L., Marino Gammazza A., Scalia F.   +4 more
core   +1 more source