Results 191 to 200 of about 90,077 (217)

Mucinous histology and resistance to immune checkpoint blockade in patients with microsatellite instability-high metastatic colorectal cancer. [PDF]

Oncologist
Nasca V, Ambrosini M, Taieb J, Cohen R, Lonardi S, Boursi B, Margalit O, Salvatore L, Ros J, Sabella G, Rossi C, Tougeron D, Guimbaud R, Gallois C, Elez ME, Bergamo F, Cremolini C, Overman MJ, André T, Randon G, Pietrantonio F.   +20 more
europepmc   +1 more source

CEBPG‐Mediated Palmitic Acid Adaptation of Cancer‐Associated Fibroblasts Drives Metastasis of Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
This study reveals a metabolic signaling axis in the OSCC microenvironment where palmitic acid (PA) drives the activation of CAFs. PA uptake triggers CEBPG‐dependent epigenetic remodeling to upregulate ERN1 and TMBIM6, thereby mitigating ER stress. This adaptive program sustains CAF survival and the pro‐metastatic phenotype, establishing this pathway ...
Yiling Duan, Yitong Li, Yufei Wu, Xiao Yang, Rui Li, Hui Zhao, Zhengjun Shang   +6 more
wiley   +1 more source

Publisher Correction: Mutant KRAS vaccine with dual checkpoint blockade in resected pancreatic cancer: a phase I trial. [PDF]

Nat Commun
Huff AL, Haldar SD, Girgis AA, Wang HH, Danilova L, Heumann T, Berg M, Wang Y, Andaloori L, Hernandez A, Longway G, Barrett B, Zhu Z, Davis-Marcisak E, Thoburn C, Leatherman J, Mitchell S, Lee JW, Shu DH, Konig MF, Mog BJ, Montagne J, Coyne EM, Bever K, Baretti M, Yarchoan M, Anders RA, Kagohara LT, Laheru D, Thomas AM, Durham J, Nauroth JM, Lu J, Wang H, Fertig EJ, Ho WJ, Azad NS, Jaffee EM, Zaidi N.   +38 more
europepmc   +1 more source

Artificial intelligence-enabled multi-omics biomarkers for immune checkpoint blockade: mechanisms, predictive modeling, and clinical translation. [PDF]

Front Immunol
Wang X, Xiong D, Cui S, Duan B, Ding G, Huang Y, Wang Q.   +6 more
europepmc   +1 more source

CLEC2B-KLRB1 axis acts as an immune checkpoint, governing the exhaustion of CD8⁺ T cells and their resistance to immune checkpoint blockade. [PDF]

J Immunother Cancer
Cheng J, Lu J, Gao Z, Xiao Y, Chen P, Zhou M, Huang D, Zhao Z, Zhang X, Zhao Y, Li M, Gu J.   +11 more
europepmc   +1 more source

When Immunotherapy Hits the Joints: A Case of Late-Onset Polyarthritis Induced by an Immune Checkpoint Blockade and Literature Review. [PDF]

Cureus
Wu Y, Digregorio A.
europepmc   +1 more source

Humoral IgG1 responses to tumor antigens underpin clinical outcomes in immune checkpoint blockade. [PDF]

Nat Med
Gonzalez-Kozlova E, Sweeney R, Figueiredo I, Tuballes K, Ozbey S, Hamon P, Park MD, Ioannou G, Nose Y, Guo R, Restrepo P, Buckup M, Roudko V, Hennequin C, Le Berichel J, Venturini N, Halasz L, Troncoso L, Tabachnikova A, Chang C, Reid A, Brown H, Chin T, Cabal R, Mattiuz R, Eikawa S, Del Valle DM, Gonsalves TR, LaMarche NM, Jamal H, Lansky A, Yi N, Nelson D, Morgenroth-Rebin J, Merand R, Villagomez B, D'Souza D, Radkevich E, Nie K, Chen Z, Tada Y, Nishikawa H, Ward SC, Fiel MI, Brody R, Tabrizian P, Gunasekaran G, Kamphorst AO, Cohen N, Curotto de Lafaille M, Hapanowicz O, Lucas N, Wu K, James N, Lin JC, Thurston G, Schwartz M, Fiaschi N, Kim-Schulze S, Merad M, Marron TU, Gnjatic S.   +61 more
europepmc   +1 more source

Author Correction: Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade for treatment of breast cancer. [PDF]

NPJ Breast Cancer
Draganov D, Han Z, Rana A, Bennett N, Irvine DJ, Lee PP.   +5 more
europepmc   +1 more source

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Conserved Interferon-γ Signaling Drives Clinical Response to Immune Checkpoint Blockade Therapy in Melanoma

Cancer Cell, 2020
Egmidio Medina, Katie M Campbell, Jason J Luke   +2 more
exaly  

The ectonucleotidase CD39 identifies tumor-reactive CD8+ T cells predictive of immune checkpoint blockade efficacy in human lung cancer

Immunity, 2023
Hira Rizvi, Charles M Rüdin
exaly