Results 211 to 220 of about 143,566 (359)

Cancer immunogenomics: Computational neoantigen identification and vaccine design [PDF]

, 2016
Coffman, Adam, Graubert, Aaron, Griffith, Malachi, Griffith, Obi L, Hundal, Jasreet, Kiwala, Susanna, Mardis, Elaine R, McMichael, Joshua, Miller, Christopher J, Walker, Jason   +9 more
core   +2 more sources

Supplementary Figure 5 from Immune Checkpoint Blockade Delays Cancer Development and Extends Survival in DNA Polymerase Mutator Syndromes

Akshada Sawant, Fuqian Shi, Eduardo Cararo Lopes, Zhixian Hu, Somer Abdelfattah, Jennele Baul, Jesse R. Powers, Christian S. Hinrichs, Joshua D. Rabinowitz, Chang S. Chan, Edmund C. Lattime, Shridar Ganesan, Eileen White   +12 more
openalex   +1 more source

Chemotherapy and checkpoint blockade [PDF]

Nature Reviews Urology, 2018
openaire   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Antibody-lectin chimeras for glyco-immune checkpoint blockade. [PDF]

Nat Biotechnol
Stark JC, Gray MA, Ibarlucea-Benitez I, Lustig M, Bond A, Cho B, Govil I, Luu T, Priestley MJ, Veth TS, Errington WJ, Bruncsics B, Ribi MK, Williams LA, Sarkar CA, Wisnovsky S, Riley NM, Morrissey MA, Valerius T, Ravetch JV, Bertozzi CR.   +20 more
europepmc   +1 more source

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source

Immune checkpoint blockade in cancer: current insights and future horizons. [PDF]

Discov Oncol
Saman H, Makni-Maalej K, El-Ella DMA, Al-Tamimi MY, AbuHaweeleh MN, Abuhayeh N, Ismail MA, Prabhu KS, Fernandes Q, Jabi T, Elhussein R, Inchakalody VP, Merhi M, Dermime S, Uddin S.   +14 more
europepmc   +1 more source

Decoding Triphenotypic Neutrophils in Cervical Cancer Evolution and Targeting SPP1+/GBP1+/ELOVL5+ Tumor‐Associated Neutrophils to Sensitize Immunotherapy

Advanced Science, EarlyView.
The functional schematic diagram of tumor associated neutrophils. Abstract Enhancing cervical cancer (CC) immunotherapy requires deciphering the heterogeneous tumor immune microenvironment (TIME), particularly neutrophil phenotypic dynamics. Here, 1) we collected 543 CC cases to find that patients with elevated neutrophil levels have a higher incidence
Xingyu Chang, Xinyu Qu, Tingting Ren, Tong Wu, Weiyong Gu, Jingxin Ding, Keqin Hua, Junjun Qiu   +7 more
wiley   +1 more source

Supplementary Figures from Predictive Immune-Checkpoint Blockade Classifiers Identify Tumors Responding to Inhibition of PD-1 and/or CTLA-4

, 2023
Oscar Krijgsman, Kristel Kemper, Julia Boshuizen, David W. Vredevoogd, Elisa A. Rozeman, Sofía Ibáñez Molero, Beaunelle de Bruijn, Paulien Cornelissen‐Steijger, Aida Shahrabi, Martin Del Castillo Velasco‐Herrera, Ji‐Ying Song, Maarten A. Ligtenberg, Roelof J.C. Kluin, Thomas Kuilman, Petra Ross‐Macdonald, John B.A.G. Haanen, David J. Adams, Christian U. Blank, Daniel S. Peeper   +18 more
openalex   +2 more sources

GNL3 Orchestrates AR Transcriptional Programs to Drive Castration‐Resistant Prostate Cancer and Immune Evasion

Advanced Science, EarlyView.
GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang, Tin Long Cheong, Nitin Narwade, Dandan Dong, Mokan Deng, Zhengqiang Miao, Zhaoqiang Ding, Wenchao Li, Kate Man Kei Lei, Gong‐Hong Wei, Terence Chuen Wai Poon, Chu‐Xia Deng, Edwin Cheung   +12 more
wiley   +1 more source