Results 221 to 230 of about 143,566 (359)

YBX1&YBX3 as novel targets to potentiate immune checkpoint blockade response in gliomas. [PDF]

Neuro Oncol
Ali H, Zhou N, Chen L, van Hijfte L, Tulaiha R, Karri V, Zhou Y, Habashy K, Arrieta VA, Kim KS, Duffy J, Yeeravalli R, Tiek DM, Song X, Mishra S, Horbinski C, Lee-Chang C, Ahmed A, Wang L, Heiland DH, Sonabend AM, Dmello C.   +21 more
europepmc   +1 more source

Deep Learning‐Powered Scalable Cancer Organ Chip for Cancer Precision Medicine

Advanced Science, EarlyView.
This scalable, low‐cost Organ Chip platform, made via injection molding, uses capillary pinning for hydrogel confinement and supports versatile tissue coculture and robust imaging. Deep learning enables label‐free, sensitive phenotypic analysis.
Yu‐Chieh Yuan, Beibei Xu, Jenna McCormack, XuHai Huang, Jingzhe Ma, Thomas Marshall, Yacong Sun, Hardeep Singh, Alyssa Fanelli, Gauri Kulkarni, Ji Hye Seo, Paige Gilbride, Bing Wei, Bo Wang, Yanyan Liu, Fei Ma, Lin Zhou, Shuyang Wang, Xiaohua Qian, Zhiyong Xie, Polina Golland, Longlong Si, Yu Shrike Zhang, Xin Xie, Haiqing Bai   +24 more
wiley   +1 more source

Keeping Wnt in check for efficient checkpoint blockade in glioblastoma. [PDF]

Proc Natl Acad Sci U S A
Melssen M, Dimberg A.
europepmc   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

Bacterial colonization of tumors drives immune activation and checkpoint blockade efficacy. [PDF]

Sci Rep
Rolig AS, Ziglari T, McGee GH, Kasiewicz MJ, Kolbaba K, Simons ND, Pucilowska J, Sfanos K, Redmond WL.   +8 more
europepmc   +1 more source

773 SOF10, selectively blocking latent TGF-β1 activation, potentiates the efficacy of checkpoint blockade therapy by modulating CAF dynamics and T cell infiltration [PDF]

Izumi Sato, Masakazu Kanamori, Kenji Nakagawa, Silvia Sun, Kentaro Asanuma, Hiroki Kawauchi, Yoko Kayukawa, Saori Matsuo, Meiri Shida-Kawazoe, Daiki Kashiwagi, Takehisa Kitazawa, Tomoyuki Igawa, Hideaki Shimada   +12 more
openalex   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Merkel cell carcinoma immunotherapy: key questions in the era of immune checkpoint blockade. [PDF]

J Immunother Cancer
Becker JC, Lodde G, Haist M, Ugurel S.
europepmc   +1 more source

Boiling histotripsy and in-situ CD40 stimulation improve the checkpoint blockade therapy of poorly immunogenic tumors

, 2020
Mohit Pratap Singh, Sri Nandhini Sethuraman, Craig Miller, Jerry R. Malayer, Ashish Ranjan   +4 more
openalex   +1 more source

The current landscape of predictive and prognostic biomarkers for immune checkpoint blockade in ovarian cancer

, 2022
Yufei Xu, Fengli Zuo, Huiling Wang, Jing Jing, Xiujing He   +4 more
openalex   +1 more source