Results 61 to 70 of about 289,858 (293)

Nucleic acid-based immune checkpoint blockade: Progress and potential

, 2021
Engaging the immune system through checkpoint blockade has become a standard of care in the treatment of many tumors. Traditionally, immune checkpoint blockade involves the use of monoclonal antibodies and whilst these have been extremely successful ...
Adam A. Walters, Walters, Adam A., Baljevan Dhadwar, Dhadwar, Baljevan, Khuloud T. Al-Jamal, Al-Jamal, Khuloud T.   +5 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma.

PLoS ONE, 2019
We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melanoma ...
Spela Kos, Alessandra Lopes, Veronique Preat, Maja Cemazar, Ursa Lampreht Tratar, Bernard Ucakar, Kevin Vanvarenberg, Gregor Sersa, Gaelle Vandermeulen   +8 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Immune checkpoint blockade in ovarian cancer [PDF]

memo - Magazine of European Medical Oncology, 2016
Increased numbers of tumour infiltrating T‑cells have long been associated with a better prognosis in ovarian cancer, which has led to the general assumption of a relevant impact of T‑cellular anti-tumour immunity in this disease. As a consequence of this knowledge, a multitude of immunologic therapies has emerged over the past years.
Weiss, Lukas, Huemer, Florian, Mlineritsch, Brigitte, Greil, Richard   +3 more
openaire   +2 more sources

Smoldering myocarditis following immune checkpoint blockade [PDF]

, 2017
Background Severe myocarditis associated with electrical conduction abnormalities and occasionally heart failure has been well documented following treatment with immune checkpoint blockade with an estimated incidence of less than 1%.
Litovsky, Silvio, Silvio H. Litovsky, Westbrook, Brian, Moslehi, Javid, Svetlana B. McKee, Douglas B. Johnson, Norwood, Timothy, Conry, Robert, Javid J. Moslehi, Brian C. Westbrook, Nina L. Terry, Johnson, Douglas, Alan S. Gertler, McKee, Svetlana, Terry, Nina, Timothy G. Norwood, Gertler, Alan, Robert M. Conry   +17 more
core   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity [PDF]

, 2017
Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients.
Sandra Lee, Pearl Bakhru, Hsing-Hui Wang, Fong, Lawrence, Wang, Hsing-Hui, Mouchess, Maria, Maria Mouchess, Maureen A. Su, Sailer, David, Kirkwood, John M, John M. Kirkwood, Khan, Imran, Su, Maureen A, Zhu, Meng-Lei, Moschos, Stergios, David Sailer, Gulati, Ajay S, Joshua Starmer, Lawrence Fong, Mark S. Anderson, Starmer, Joshua, Anderson, Mark S, Stergios Moschos, Lee K. Hong, Hong, Lee K, Lee, Sandra, Fengmin Zhao, Yafei Hou, Bakhru, Pearl, Zhao, Fengmin, Meng-Lei Zhu, Imran Khan, Ajay S. Gulati, Hou, Yafei   +33 more
core   +1 more source

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab [PDF]

, 2022
Antibody-based immunotherapy is increasingly employed to treat acute lymphoblastic leukemia (ALL) patients. Many T-ALL cells express CD38 on their surface, which can be targeted by the CD38 antibody daratumumab (DARA), approved for the treatment of ...
Marta Lustig, Arndt, Marcus, Denis M. Schewe, Christian Kellner, Leusen, Jeanette H W, Thies Rösner, Vogiatzi, Fotini, Fotini Vogiatzi, Jeanette H. W. Leusen, Burger, Renate, Niklas Baumann, Lustig, Marta, Bultmann, Miriam, Renate Burger, Bastian, Lorenz, Rösner, Thies, Schewe, Denis M., Schewe, Denis M, Baumann, Niklas, Katja Klausz, Lorenz Bastian, Thomas Valerius, Judith Petersen, Matthias Peipp, Valerius, Thomas, Arndt, Christian, Kellner, Christian, Peipp, Matthias, Klausz, Katja, Christian Arndt, Leusen, Jeanette H. W., Petersen, Judith, Miriam Bultmann   +32 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source