Results 71 to 80 of about 291,785 (296)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Intradermal DNA vaccination combined with dual CTLA-4 and PD-1 blockade provides robust tumor immunity in murine melanoma.

PLoS ONE, 2019
We aimed to explore whether the combination of intradermal DNA vaccination, to boost immune response against melanoma antigens, and immune checkpoint blockade, to alleviate immunosuppression, improves antitumor effectiveness in a murine B16F10 melanoma ...
Spela Kos, Alessandra Lopes, Veronique Preat, Maja Cemazar, Ursa Lampreht Tratar, Bernard Ucakar, Kevin Vanvarenberg, Gregor Sersa, Gaelle Vandermeulen   +8 more
doaj   +1 more source

Smoldering myocarditis following immune checkpoint blockade [PDF]

, 2017
Background Severe myocarditis associated with electrical conduction abnormalities and occasionally heart failure has been well documented following treatment with immune checkpoint blockade with an estimated incidence of less than 1%.
Litovsky, Silvio, Silvio H. Litovsky, Westbrook, Brian, Moslehi, Javid, Svetlana B. McKee, Douglas B. Johnson, Norwood, Timothy, Conry, Robert, Javid J. Moslehi, Brian C. Westbrook, Nina L. Terry, Johnson, Douglas, Alan S. Gertler, McKee, Svetlana, Terry, Nina, Timothy G. Norwood, Gertler, Alan, Robert M. Conry   +17 more
core   +1 more source

Myeloid checkpoint blockade improves killing of T-acute lymphoblastic leukemia cells by an IgA2 variant of daratumumab [PDF]

, 2022
Antibody-based immunotherapy is increasingly employed to treat acute lymphoblastic leukemia (ALL) patients. Many T-ALL cells express CD38 on their surface, which can be targeted by the CD38 antibody daratumumab (DARA), approved for the treatment of ...
Marta Lustig, Arndt, Marcus, Denis M. Schewe, Christian Kellner, Leusen, Jeanette H W, Thies Rösner, Vogiatzi, Fotini, Fotini Vogiatzi, Jeanette H. W. Leusen, Burger, Renate, Niklas Baumann, Lustig, Marta, Bultmann, Miriam, Renate Burger, Bastian, Lorenz, Rösner, Thies, Schewe, Denis M., Schewe, Denis M, Baumann, Niklas, Katja Klausz, Lorenz Bastian, Thomas Valerius, Judith Petersen, Matthias Peipp, Valerius, Thomas, Arndt, Christian, Kellner, Christian, Peipp, Matthias, Klausz, Katja, Christian Arndt, Leusen, Jeanette H. W., Petersen, Judith, Miriam Bultmann   +32 more
core   +1 more source

Immune checkpoint blockade in ovarian cancer [PDF]

memo - Magazine of European Medical Oncology, 2016
Increased numbers of tumour infiltrating T‑cells have long been associated with a better prognosis in ovarian cancer, which has led to the general assumption of a relevant impact of T‑cellular anti-tumour immunity in this disease. As a consequence of this knowledge, a multitude of immunologic therapies has emerged over the past years.
Weiss, Lukas, Huemer, Florian, Mlineritsch, Brigitte, Greil, Richard   +3 more
openaire   +2 more sources

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Combination central tolerance and peripheral checkpoint blockade unleashes antimelanoma immunity [PDF]

, 2017
Blockade of immune checkpoint proteins (e.g., CTLA-4, PD-1) improves overall survival in advanced melanoma; however, therapeutic benefit is limited to only a subset of patients.
Sandra Lee, Pearl Bakhru, Hsing-Hui Wang, Fong, Lawrence, Wang, Hsing-Hui, Mouchess, Maria, Maria Mouchess, Maureen A. Su, Sailer, David, Kirkwood, John M, John M. Kirkwood, Khan, Imran, Su, Maureen A, Zhu, Meng-Lei, Moschos, Stergios, David Sailer, Gulati, Ajay S, Joshua Starmer, Lawrence Fong, Mark S. Anderson, Starmer, Joshua, Anderson, Mark S, Stergios Moschos, Lee K. Hong, Hong, Lee K, Lee, Sandra, Fengmin Zhao, Yafei Hou, Bakhru, Pearl, Zhao, Fengmin, Meng-Lei Zhu, Imran Khan, Ajay S. Gulati, Hou, Yafei   +33 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Renal complications of immune checkpoint blockade [PDF]

Current Problems in Cancer, 2017
Immune checkpoint inhibitors have been approved for a variety of cancer species. Renal complications in use of these agents are not very common compared with other immune-related adverse events (irAE). However, it is crucial for physicians to recognize and manage renal manifestations of irAE.
Naoka, Murakami, Shveta, Motwani, Leonardo V, Riella   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source