Results 161 to 170 of about 51,381 (340)

Long-term persistency and costs associated with the use of iron chelation therapies in the treatment of Sickle cell disease within Medicaid programs. [PDF]

, 2013
OBJECTIVE: This retrospective study evaluated iron chelating therapy (ICT) discontinuation and costs in Sickle cell disease (SCD) Medicaid recipients using healthcare claims from 2006-2010.
Armstrong, Edward P, Ballas, Samir K., Sasane, Medha, Skrepnek, Grant H, Snodgrass, Susan M   +4 more
core   +1 more source

Synthetic Lethal Therapy Based on Dimorphism for Systemic Infection of Drug‐Resistant Candida albicans

Advanced Science, EarlyView.
To tackle the alarming mortality rate linked to Candida albicans infections, a synthetic lethal strategy precisely aimed at the two distinct forms of this fungus: yeast and hyphae is formulated. Ultimately, through the innovative use of macrophage membranes for drug delivery, the effectiveness of this strategy is substantially boosted while ...
Yang Gao, Jiahe Su, Jiawei Yuan, Qinyan Cao, Yue Wu, Yuyang Xiao, Guang Yang, Ruomu Xia, Jingpeng Yang, Yanan Li, Lina Wu, He Huang, Lingtong Meng   +12 more
wiley   +1 more source

Marrow Transplantation in Patients with Thalassemia Responsive to Iron Chelation Therapy [PDF]

, 1993
Guido Lucarelli, M Galimberti, Paola Polchi, Emanuele Angelucci, D Baronciani, Claudio Giardini, Marco Andreani, F Agostinelli, F. Albertini, Reginald A. Clift   +9 more
openalex   +1 more source

Chelation Therapy Associated with Antioxidant Supplementation Can Decrease Oxidative Stress and Inflammation in Multiple Sclerosis: Preliminary Results. [PDF]

Antioxidants (Basel), 2023
Vezzoli A, Mrakic-Sposta S, Dellanoce C, Montorsi M, Vietti D, Ferrero ME.   +5 more
europepmc   +1 more source

Fe‐S Protein FDX1 Triggers Tumor‐Intrinsic Innate Immunity via Mitochondrial Nucleic Acids Release to Orchestrate Ferroptosis in CCRCC

Advanced Science, EarlyView.
Restoration of the mitochondrial Fe–S protein FDX1 suppresses clear cell renal cell carcinoma by coupling ferroptosis with tumor‐intrinsic innate immune activation. FDX1 induces mitochondrial dysfunction and mtDNA/mt‐dsRNA release, activating cGAS–STING and RIG‐I/MDA5–MAVS signaling to elicit type I interferon responses, thereby promoting antigen ...
Xing Huang, Shaoqing Yu, Wenjie Wei, Wen Tao, Tianwei Cai, Lequan Wen, Jiali Ye, Chi Zhang, Huayi Feng, Senming Cao, Baojun Wang, Xin Ma, Yan Huang, Xu Zhang   +13 more
wiley   +1 more source

Evaluation of Cardiac Systolic and Diastolic Function by Echocardiographic Tei Index in Thalassemic Patients Referring to HazrateMasoumeh Hospital, Qom, Iran, 2012-2013

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2015
Background and Objectives: Early diagnosis of secondary cardiac involvement due to iron overload is very important in thalassemia patients. The aim of this study was to evaluate cardiac systolic and diastolic function by Tei Index in patients with β-
Mohammad Hossein Arjmandnia, Parvaneh Sadeghi Moghaddam, Seyed Kamal Eshagh Hosseini, Hamed Hassani, Mohammad Aghaali   +4 more
doaj  

Cell‐Free DNA‐Based Theranostics for Inflammatory Disorders

Advanced Science, EarlyView.
Summary on the dual potential of cfDNA as biomarkers and therapeutic targets for inflammatory disorders. Figure was created with BioRender.com. ABSTRACT Inflammatory disorders are characterized by immune‐mediated inflammatory cascades that can affect multiple organs.
Jiatong Li, Yumei Wang, Xiaoxi Fan, Miao Xu, Jiawen Li, Wenfei Tan, Jianxiang Zhang, Heran Li   +7 more
wiley   +1 more source

Chelation Therapy in Patients With Cardiovascular Disease: A Systematic Review. [PDF]

J Am Heart Assoc, 2022
Ravalli F, Vela Parada X, Ujueta F, Pinotti R, Anstrom KJ, Lamas GA, Navas-Acien A.   +6 more
europepmc   +1 more source

NADH‐Reductive Stress Induced by Dihydrolipoamide Dehydrogenase Activation Contributes to Cuproptosis

Advanced Science, EarlyView.
This study demonstrates a cuproptosis mechanism involving nicotinamide adenine dinucleotide (NADH)‐reductive stress in neural cells. Copper activates dihydrolipoamide dehydrogenase under mitochondrial pH, accumulating NADH. Copper also induces mitochondrial permeability transition pore opening, facilitating NADH translocation to the cytosol and ...
Si‐Yi Zhang, Xing‐Hua Ren, Cheng‐Hong Zhang, Zhan‐You Wang   +3 more
wiley   +1 more source

Back of the envelope estimates of environmental damage costs in Mexico [PDF]

For developing countries, budget constraints help set the agenda on mitigating environmental damage, one of the indelible marks of our era. Political considerations often dictate the measures taken.
Margulis, Sergio
core