Results 91 to 100 of about 9,197 (244)

Ensaios densitométricos para a avaliação, ao longo de um ciclo anual, d e alcalóides solúveis em água de raízes de Chelidonium majus L. (Papaveracea), nos Açores [PDF]

, 1995
Prepararam-se extractos de alcalóides solúveis em água de raízes de Chelidonium majus L. (celidónia), colhida em terrenos incultos nos Açores, mensalmente, ao longo de um ano.
Pavão, Maria Leonor, Pinto, Ruy Eugénio   +1 more
core  

Ca2+-Dependent Phosphorylation of RyR2 Can Uncouple Channel Gating from Direct Cytosolic Ca2+ Regulation [PDF]

, 2011
Phosphorylation of the cardiac ryanodine receptor (RyR2) is thought to be important not only for normal cardiac excitation-contraction coupling but also in exacerbating abnormalities in Ca²+ homeostasis in heart failure.
John Colyer, Rebecca Sitsapesan, Samantha J. Pitt, Simon Carter   +3 more
core   +2 more sources

Pyrrolo‐Fused Phenanthridines as Potential Anticancer Agents: Synthesis, Prediction, and Biological Evaluation

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 9, September 2025.
ABSTRACT We report the synthesis of four novel monoquaternary salts and four fused pyrrolo‐phenanthridine compounds, fully characterized by NMR, FT‐IR, and mass spectrometry. Guided by theoretical predictions, including molecular docking studies, we assessed their cytotoxic activity and biocompatibility.
Ashraf Al‐Matarneh, Natalia Simionescu, Alina Nicolescu, Narcis Cibotariu, Ramona Danac, Maria‐Cristina Al‐Matarneh, Ionel I. Mangalagiu   +6 more
wiley   +1 more source

Chelerythrine down regulates expression of VEGFA, BCL2 and KRAS by arresting G-Quadruplex structures at their promoter regions

Scientific Reports, 2017
A putative anticancer plant alkaloid, Chelerythrine binds to G-quadruplexes at promoters of VEGFA, BCL2 and KRAS genes and down regulates their expression.
Jagannath Jana, S. Mondal, Payel Bhattacharjee, Pallabi Sengupta, T. Roychowdhury, Pranay Saha, Pallob Kundu, S. Chatterjee   +7 more
semanticscholar   +1 more source

Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)

Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.
This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni, Milena Costa Bassicheto, Maria Vitória de Oliveira, Ana Beatriz dos Santos de Souza, Gabriella Melo Alves, Thiago André Moura Veiga   +5 more
wiley   +1 more source

Dual COX-2/5-LOX inhibitors from Zanthoxylum simulans inhibit gastric cancer cells by cross-mediating thyroid, estrogen, and oxytocin signaling pathways

Frontiers in Chemistry
Cyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX) are overexpressed in gastric cancer cells, the dual inhibitors of which exhibit potential against metastasis and invasion with fewer side effects.
Yong-Qiang Tian, Jing Liu, Peng Cheng, Jian Zou, Hui-Fang Xu, Xin-Hua Shi, Yi-Sheng Zhang, Ling Mei   +7 more
doaj   +1 more source

Greater Celandine's Ups and Downs−21 Centuries of Medicinal Uses of Chelidonium majus From the Viewpoint of Today's Pharmacology

Frontiers in Pharmacology, 2018
As antique as Dioscorides era are the first records on using Chelidonium as a remedy to several sicknesses. Inspired by the “signatura rerum” principle and an apparent ancient folk tradition, various indications were given, such as anti-jaundice and ...
Sylwia Zielińska, Anna Jezierska-Domaradzka, Anna Jezierska-Domaradzka, Magdalena Wójciak-Kosior, Ireneusz Sowa, Adam Junka, Adam M. Matkowski, Adam M. Matkowski   +7 more
doaj   +1 more source

Photoswitchable diacylglycerols enable optical control of protein kinase C. [PDF]

, 2016
Increased levels of the second messenger lipid diacylglycerol (DAG) induce downstream signaling events including the translocation of C1-domain-containing proteins toward the plasma membrane. Here, we introduce three light-sensitive DAGs, termed PhoDAGs,
A Betz, A Burgalossi, A Nadler, A Nadler, A Wuttke, AC Newton, Alexander Gottschalk, C Yang, Carsten Schultz, CI Bargmann, CJ Nolan, D Toullec, DA Jacobson, DA Jacobson, David J Hodson, DB Konrad, Dirk Trauner, Dmytro A Yushchenko, E Oancea, F Plenge-Tellechea, F Varoqueaux, FM Ashcroft, G Reither, GA Rutter, Guy A Rutter, H Fliegl, H Ishihara, J Basu, J Das, JA Frank, JA Lewis, James Allen Frank, Jatin Nagpal, JD Violin, JD Violin, JE Toettcher, Jeong-Seop Rhee, JM Herbert, JS Rhee, JT Fleming, KDB Wierda, L Coussens, M Almena, M Putyrski, MA Ravier, MA Ravier, MS Pessin, N Brose, N Brose, N Brose, Nils Brose, Noa Lipstein, P Bergsten, PA Marignani, PA Wender, PK Dadi, RJ Davis, S Brenner, S Corbalán-García, S Feng, T Hofmann, TR Mahoney, U Kikkawa, X Lou, Y Kurohane Kaneko, Y Zhao   +65 more
core   +3 more sources

Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions

Ibrain, Volume 11, Issue 2, Page 162-184, Summer 2025.
Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra, Reena Rani Nayak, Ankit Ganeshpurkar, Prashant Tiwari, Dileep Kumar   +4 more
wiley   +1 more source

Induction of reactive oxygen species-stimulated distinctive autophagy by chelerythrine in non-small cell lung cancer cells

Redox Biology, 2017
Chelerythrine (CHE), a natural benzo[c]phenanthridine alkaloid, shows anti-cancer effect through a number of mechanisms. Herein, the effect and mechanism of the CHE-induced autophagy, a type II programmed cell death, in non-small cell lung cancer (NSCLC)
Zheng-hai Tang, Wen-Xiang Cao, Zhao-Yu Wang, Jiahong Lu, Bo Liu, Xiuping Chen, Jin-jian Lu   +6 more
semanticscholar   +1 more source