Results 101 to 110 of about 9,197 (244)

Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review

CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.
Schematic diagram for the excitatory glutamate receptors for morphine tolerance and drugs targeting glutamate receptors in morphine tolerance. This figure illustrates the main mechanisms by which the major ionic and metabotropic glutamatergic receptors are involved in the process of morphine tolerance.
Min Huang, Limin Luo, Wenying Wang, Hao Xu, Moxi Chen, Xiaqing Ma, Tao Xu   +6 more
wiley   +1 more source

Сells of buccal epithelium charge state in children with lesions of the oral mucosa at the background of acute lymphoblastic leukemia in the dynamics of the treatment [PDF]

, 2018
To study the charge state of buccal epithelial cells (BEC) in children with lesions of the mouth mucous membrane at the background of acute lymphoblastic leukemia in the dynamics of the treatment. The charge state of BEC in 126 children with lesions of
Buniatian, Kristina, Khotimskaya, Julia, Kovach, Ilona, Lavreniuk, Yana   +3 more
core  

Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac [PDF]

, 2017
BACKGROUND AND PURPOSE: Myocardial cAMP elevation confers cardioprotection against ischaemia/reperfusion (I/R) injury. cAMP activates two independent signalling pathways, PKA and Epac.
Alexander, Alexander, Almahariq, Appukuttan, Asimakis, Bain, Bergmeyer, Bers, Bos, Calderon-Sanchez, Cannavo, Cazorla, Chen, Christensen, Clarke, Cross, Curtis, Dekker, Depre, Dorn, Dudley, Duquesnes, Eltzschig, Glas, Glass, Gomez, Halestrap, Halestrap, Hewer, Honda, Hothi, Juhaszova, Khaliulin, Khaliulin, Khaliulin, Khaliulin, Kilkenny, Kimura, Li, Littlejohns, Lochner, Lymperopoulos, Mangmool, McGrath, Metrich, Mochly-Rosen, Novalija, Oestreich, Okumura, Omori, Pasdois, Pasdois, Pereira, Pereira, Rau, Rehmann, Rooij, Schmidt, Southan, Wang, Williams, Yang, Zhang, Zhu   +63 more
core   +2 more sources

Acute memory phase of sevoflurane preconditioning is associated with sustained translocation of protein kinase C-alpha and epsilon, but not delta, in isolated guinea pig hearts. [PDF]

, 2009
BACKGROUND AND OBJECTIVE: Anaesthetic preconditioning (APC) exerts cardioprotective effects by reducing infarct size and improving recovery of contractile function after ischaemia-reperfusion.
Domae, Naochika, Figueredo, Vincent M, Inamura, Yoshitaka, Kaneda, Kazuhiro, Kotani, Junichiro, Miyamae, Masami, Okusa, Chika, Onishi, Anna, Sugioka, Shingo   +8 more
core   +1 more source

Recent Developments in Deep Eutectic Solvents Applications in Liquid Chromatography: 2019–2025

Journal of Separation Science, Volume 48, Issue 5, May 2025.
ABSTRACT Deep eutectic solvents (DES) are used as mobile phase and stationary phase modifiers, or as for the stationary phase itself for thin layer/liquid/supercritical chromatography. Their specific properties can improve the separation selectivity, reduce peak tailing, and shorten the separation time.
Derya Demir, Joanna Antos, František Švec, Hana Sklenářová   +3 more
wiley   +1 more source

Modulatory Effect of Chelidonium majus Extract and Its Alkaloids on LPS-Stimulated Cytokine Secretion in Human Neutrophils

Molecules, 2020
Due to certain differences in terms of molecular structure, isoquinoline alkaloids from Chelidonium majus engage in various biological activities.
Sylwia Zielińska, Monika Ewa Czerwińska, Magdalena Dziągwa-Becker, Andrzej Dryś, Mariusz Kucharski, Anna Jezierska-Domaradzka, Bartosz J. Płachno, Adam Matkowski   +7 more
doaj   +1 more source

Editorial: Cell and molecular signaling, and transport pathways involved in growth factor control of synaptic development and function [PDF]

, 2015
Since the discovery of nerve growth factor (NGF) more than a half century ago (Levi-Montalcini and Cohen, 1960), the prototypic neurotrophin family has included brain derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3), and neurotrophin-4 (NT-4 ...
Constantine-Paton, Martha, Ip, Nancy Y., Yoshii, Akira   +2 more
core   +2 more sources

Supramolecular Chiral Amplification Mediated by Tiny Structural Changes in Natural Binary Carrier‐Free Hydrogels with Promotion Methicillin‐Resistant Staphylococcus aureus‐Infected wound Healing by Inhibiting the Complement System

Small Structures, Volume 6, Issue 5, May 2025.
Baicalin, scutellarin, and chelerythrine can self‐assemble into chiral supramolecular hydrogels. The hydroxyl (OH) groups play a crucial role in modulating the π–π interactions and hydrogen bonding within the hydrogel's 3D network, resulting in amplified supramolecular chirality. This enhancement contributes to the increased stability and injectability
Zhijia Wang, Jihui Lu, Wenmin Pi, Ran Xu, Shuchang Yao, Xiang Zhang, Luping Yang, Yihang Zhao, Jichang Wei, Gen Li, Yiqing Huang, Haimin Lei, Xuemei Huang, Penglong Wang   +13 more
wiley   +1 more source

Chelerythrine Inhibits Human Hepatocellular Carcinoma Metastasis in Vitro.

Biological and Pharmaceutical Bulletin, 2018
Chelerythrine (CHE) is a type of benzophenanthridine alkaloid found in many herbs and is also the main alkaloid constituent of Toddalia asiatica (L.) LAM.
Yuan-zhang Zhu, Yingyi Pan, Gui-jun Zhang, Yingchun Wu, Wei Zhong, Chunxiao Chu, Yun Qian, Guofu Zhu   +7 more
semanticscholar   +1 more source

Mitochondrial Electron Flow Dynamics Imaging for Assessing Mitochondrial Quality and Drug Screening

Advanced Science, Volume 12, Issue 9, March 6, 2025.
A Mito‐EF tracker (Mito‐EFT) is developed to investigate Mito‐EF's role in mitochondrial quality control. It maps the increased Mito‐EF dynamics in healthy, fiber‐like mitochondria compared to damaged, round ones and highlights its correlation with morphological remodeling during fission and fusion, thereby supporting Mito‐EF as a crucial parameter for
Youxiao Ren, Ling‐Ling Wu, Wenjing Song, Yanan Gao, Litao Shao, Zhiyuan Lu, Songsong Wang, Xintian Shao, Zhenjie Yu, Mengrui Zhang, Jing Wu, Liwen Han, Kewu Zeng, Qixin Chen   +13 more
wiley   +1 more source