Results 121 to 130 of about 3,120 (165)

Selective inhibition of monoamine oxidase A by chelerythrine, an isoquinoline alkaloid

Bioorganic and Medicinal Chemistry Letters, 2018
Chelerythrine, an isoquinoline alkaloid isolated from the herbaceous perennial Chelidonium majus, was found to potently and selectively inhibit an isoform of recombinant human monoamine oxidase-A (MAO-A) with an IC50 value of 0.55 µM. Chelerythrine was a reversible competitive MAO-A inhibitor (Ki = 0.22 µM) with a potency much greater than toloxatone ...
Hyung Won Ryu, Hoon Kim, Daeui Park
exaly   +3 more sources

The pharmacological action of chelerythrine

Journal of the American Pharmaceutical Association (Scientific ed.), 1955
Chelerythrine hydrochloride, has been subjected to a pharmacologic study. Its action was determined on the blood pressure, uterus, and intestine, and the nictitating membrane of eighteen cats and one dog. Chelerythrine lowered the blood pressure in anesthetized cats, preceded by a brief pressor action.
C E, POWELL, K K, CHEN
openaire   +2 more sources

In vitro antifungal activity and possible mechanisms of action of chelerythrine

Pesticide Biochemistry and Physiology, 2020
Chelerythrine (CHE) possesses broad pharmacological activities. In this study, the extract of Chelidonium majus L. were characterized by high performance liquid chromatography (HPLC), infrared radiation (IR) spectroscopy and nuclear magnetic resonance (NMR). It was proved that the extract was CHE.
Na Zhao, Min Zhao, Xuefeng Liu
exaly   +3 more sources

Structure of Chelerythrine Base

Journal of Natural Products, 1995
The structure of chelerythrine free base was examined. When chelerythrine chloride [1b] was treated with aqueous K2CO3 solution, bis[6-(5,6-dihydrochelerythrinyl)] ether [3] was obtained. An excess of aqueous ammonia under the same conditions yielded bis[6-(5,6-dihydrochelerythrinyl)] amine [4].
Jiří Dostál, Eva Táborská, Jiří Slavík, Milan Potáček, Edmond de Hoffmann   +4 more
openaire   +1 more source

Protective effect of chelerythrine on gentamicin‐induced nephrotoxicity

Cell Biochemistry and Function, 2004
AbstractDespite their beneficial effects, aminoglycosides including gentamicin (GEN) have considerable nephrotoxic side‐effects. The toxicity of GEN at the level of the kidney seems to relate to the generation of reactive oxygen species (ROS). ROS have been reported to be involved in the activation of protein kinase C (PKC).
Bay-Karabulut, AYSUN, UÇAR, MUHARREM, Acet, A., VARDI, NİGAR, Yanilmaz, M., PARLAKPINAR, HAKAN, Kavakli, A., POLAT, ALAADİN, TAŞDEMİR, SERAP   +8 more
openaire   +3 more sources

A biomimetic conversion of berberine into chelerythrine and dihydrochelerythrine

Journal of the Chemical Society, Chemical Communications, 1984
A novel and efficient synthesis of the benzo[c]phenanthridine alkaloids, chelerythrine and dihydrochelerythrine, from berberine was developod via a biogenetic route.
Miyoji Hanaoka, Toshio Motonishi, Chisato Mukai   +2 more
openaire   +1 more source

Investigations with the selective PKC inhibitor chelerythrine on human basophils

Agents and Actions, 1994
Modulation of protein kinase C (PKC) activity in basophils (B) can influence IgE-mediated histamine release (HR). The present study investigated the effects of chelerythrine, which inhibits isolated PKC (IC50 0.7 microM), on different activation pathways in B. Fc epsilon RI-mediated HR was strongly inhibited by chelerythrine (86.5 +/- 5.4%, 5 microM, n
E, von Stebut, U, Amon, J M, Herbert, H H, Wolff   +3 more
openaire   +2 more sources

Synthesis of sanguinarine, chelerythrine, and oxysanguinarine

Collection of Czechoslovak Chemical Communications, 1984
Benzo[c]phenanthridines Va and Vb have been prepared by photocyclization of amines IVa and IVb and transformed into the alkaloids sanguinarine (VIa) and chelerythrine (VIb). Oxysanguinarine (XIV) has been prepared from diazoketone XVIII.
openaire   +1 more source

Unique Pharmacological Interactions of Taurine and Chelerythrine in the Retina

1998
The effects of taurine and chelerythrine (CHT) on ATP-dependent calcium uptake and the phosphorylation of the approximately 20 kDa phosphoprotein in the retina were compared. In the absence of the CHT, taurine stimulated ATP-dependent calcium uptake and attenuated the phosphorylation of the approximately 20 kDa phosphoprotein.
J D, Militante, J B, Lombardini
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Chelerythrine is a potent and specific inhibitor of protein kinase C

Biochemical and Biophysical Research Communications, 1990
The benzophenanthridine alkaloid chelerythrine is a potent, selective antagonist of the Ca++/phospholopid-dependent protein kinase (Protein kinase C: PKC) from the rat brain. Half-maximal inhibition of the kinase occurs at 0.66 microM. Chelerythrine interacted with the catalytic domain of PKC, was a competitive inhibitor with respect to the phosphate ...
J M, Herbert, J M, Augereau, J, Gleye, J P, Maffrand   +3 more
openaire   +2 more sources