Results 131 to 140 of about 3,120 (165)

Configurations and conformations of sanguinarine and chelerythrine free bases stereoisomers

Journal of Molecular Structure, 2002
Abstract The configurations and conformations of bimolecular aminoacetals of benzo[c]phenanthridine alkaloids sanguinarine and chelerythrine were investigated by NMR spectroscopy, quantum chemical calculations, and X-ray analysis. The results of the complete computational conformational analysis, the calculation of the chemical shielding of the ...
Toušek, J., Dommisse, R., Dostál, J., Zak, Z., Pieters, Luc, Marek, R.   +5 more
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Microarray Analysis of the Chelerythrine-Induced Transcriptome of Mycobacterium tuberculosis

Current Microbiology, 2010
Chelerythrine (a natural quaternary benzophenanthridine alkaloid) is an extract from the roots of Chelidonium majus with potential antimycobacterial activity. To reveal the possible mechanism of action of chelerythrine against Mycobacterium tuberculosis (M.
Junchao, Liang, Fanli, Zeng, Aizhen, Guo, Liqiang, Liu, Na, Guo, Lei, Li, Jing, Jin, Xiuping, Wu, Mingyuan, Liu, Dan, Zhao, Yang, Li, Qi, Jin, Lu, Yu   +12 more
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Chelerythrine ameliorates acute cardiac allograft rejection in mice

Transplant Immunology, 2016
The improvement in graft survival over the past decade has been mainly due to calcineurin inhibitors, which interfere with the calcium-mediated pathway. Recently, other pathways such as those mediated by protein kinase C (PKC) are coming into view. The purpose of this study was to assess the immunosuppressive properties of chelerythrine, a specific PKC
Qiyi, Zhang, Yang, Tian, Jixuan, Duan, Jingjin, Wu, Sheng, Yan, Hui, Chen, Xueqin, Meng, Kwabena Gyabaah, Owusu-Ansah, Shusen, Zheng   +8 more
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Sanguinarine and Chelerythrine as Inhibitors of Aromatic Amino Acid Decarboxylase

Journal of Enzyme Inhibition, 1996
Quaternary benzo[c]phenanthridine alkaloids sanguinarine, chelerythrine and their dihydroderivatives were tested as inhibitors of aromatic amino acid decarboxylase (EC 4.1, 1.28, AAD) from rat liver. Sanguinarine and chelerythrine exhibited strong inhibition of AAD with Ki 1.2 x 10(-4) M and 5.8 x 10(-4) M, respectively, while no inhibitory effect was ...
J, Drsata, J, Ulrichová, D, Walterová
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Staurosporine but not chelerythrine inhibits regeneration in hippocampal organotypic cultures

Synapse, 1997
A mechanical lesion in hippocampal organotypic cultures is followed by a recovery process involving scar formation, sprouting of fibres and formation of new functional synapses. Here we tested the effect of staurosporine and chelerythrine, two protein kinase C (PKC) inhibitors, on this lesion-induced neurite outgrowth of Shaffer collaterals.
Toni, Nicolas, Stoppini, Luc, Muller, Dominique   +2 more
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Chelerythrine chloride binding of guanosine in aqueous solution

Chinese Chemical Letters, 2009
Abstract In this work, the interaction between chelerythrine (CHE) and guanosine is studied using UV–vis and fluorescence measurements at various temperatures. The UV–vis spectra show that the increasing guanosine concentrations result in the decreasing absorption intensity and red shift of CHE E absorption band (267 nm). The fluorescence spectra are
Fan Liu, Jian Bin Zhang, Zheng Fu Zhang, Xiao Yan Zhang, Zuo Peng Du, Xiong Hui Wei   +5 more
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Induction of respiration-deficient mutants in Saccharomyces cerevisiae by chelerythrine

FEMS Microbiology Letters, 1994
Chelerythrine and sanguinarine, two structurally related benzo/c/phenanthridine alkaloids, prevented growth of yeast cells in medium containing either glucose or non-fermentable carbon sources. At concentrations permitting growth of the yeast Saccharomyces cerevisiae, chelerythrine, but not sanquinarine, induced cytoplasmic respiration-deficient ...
V, Krivjanský, M, Obernauerová, J, Ulrichová, V, Simánek, J, Subík   +4 more
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Differential effect of the benzophenanthridine alkaloids sanguinarine and chelerythrine on glycine transporters

Neurochemistry International, 2011
Glycine transporter inhibitors modulate the transmission of pain signals. Since it is well known that extracts from medicinal plants such as Chelidonium majus exhibit analgesic properties, we investigated the effects of alkaloids typically present in this plant on glycine transporters.
Frantisek, Jursky, Martina, Baliova
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Hydrochromism behaviors of solid forms of chelerythrine hydrochloride

CrystEngComm, 2019
Salt formation has the potential to produce smart stimulus–response fluorescent materials without modifying the main chemical structures, especially for unstable stem-nucleus structures, and this is investigated in this work.
Meiqi Li, Zhen Li, Jian-rong Wang, Xuefeng Mei   +3 more
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[Advance in studies on pharmacological activities of chelerythrine].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2014
Chelerythrine is a kind of benzo[c] phenanthridine alkaloids, with such pharmacological activities as antitumor, antibiosis and anti-inflammation, which is widely found in plant of Fumariaceae, Papaveraceae, Ranunculaceae and Rutaceae families.
Pei-Qing, Wang, Zhen-Hua, Yin, Wen-Yi, Kang   +2 more
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