Results 61 to 70 of about 3,120 (165)
Química NovaA sensitive, simple, rapid and reliable HPLC-DAD method for the analysis of the benzylisoquinoline alkaloids (BIA's) content in Argemone mexicana (Papaveraceae) is presented.
Jorge F. Xool-Tamayo +5 more
doaj +1 more source
Basic &Clinical Pharmacology &Toxicology, Volume 137, Issue 4, October 2025.ABSTRACT Cytochrome P450 3A4 (CYP3A4) is one of the most important members of the cytochrome P450 subfamily, which is involved in the catalytic process of many drug activation or deactivation. Meanwhile, it is also a risk factor for drug‐induced toxic reactions.
Fang Wang +7 more
wiley +1 more source
Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 9, September 2025.ABSTRACT We report the synthesis of four novel monoquaternary salts and four fused pyrrolo‐phenanthridine compounds, fully characterized by NMR, FT‐IR, and mass spectrometry. Guided by theoretical predictions, including molecular docking studies, we assessed their cytotoxic activity and biocompatibility.
Ashraf Al‐Matarneh +6 more
wiley +1 more source
Nonconventional Techniques in Plant Alkaloid Extraction: A Decade of Progress (2014–2023)
Chemistry &Biodiversity, Volume 22, Issue 8, August 2025.This figure seeks to represent the evolution of the different unconventional approaches that were adopted for the extraction of plant‐derived alkaloids during the decade from 2014 to 2023. ABSTRACT Plant metabolism encompasses primary and secondary pathways, with secondary metabolism yielding diverse natural products crucial for plant adaptation and ...
Victor Menezes Sipoloni +5 more
wiley +1 more source
Navigating the treatment landscape of Alzheimer's disease: Current strategies and future directions
Ibrain, Volume 11, Issue 2, Page 162-184, Summer 2025.Alzheimer's disease treatment is evolving rapidly, with emerging strategies targeting multiple disease pathways. This graphical abstract highlights the shift from traditional therapies to innovative approaches that hold promise for improving outcomes.
Tapas Kumar Mohapatra +4 more
wiley +1 more source
Frontiers in ChemistryCyclooxygenase 2 (COX-2) and 5-lipoxygenase (5-LOX) are overexpressed in gastric cancer cells, the dual inhibitors of which exhibit potential against metastasis and invasion with fewer side effects.
Yong-Qiang Tian +7 more
doaj +1 more source
Frontiers in Pharmacology, 2018 As antique as Dioscorides era are the first records on using Chelidonium as a remedy to several sicknesses. Inspired by the “signatura rerum” principle and an apparent ancient folk tradition, various indications were given, such as anti-jaundice and ...
Sylwia Zielińska +7 more
doaj +1 more source
Targeting Excitatory Glutamate Receptors for Morphine Tolerance: A Narrative Review
CNS Neuroscience &Therapeutics, Volume 31, Issue 6, June 2025.Schematic diagram for the excitatory glutamate receptors for morphine tolerance and drugs targeting glutamate receptors in morphine tolerance. This figure illustrates the main mechanisms by which the major ionic and metabotropic glutamatergic receptors are involved in the process of morphine tolerance.
Min Huang +6 more
wiley +1 more source
Frontiers in Pharmacology, 2018 Chelerythrine (CH), is a kind of benzo[c] phenanthridine alkaloid isolated from plants such as Chelidonium, with pharmacological activities as antitumor, antibiosis and anti-inflammation.
Lu Fan +9 more
doaj +1 more source
Metabolomics analysis of the effects of chelerythrine on Ustilaginoidea virens.
Journal of pesticide scienceRice false smut (RFS) caused by Ustilaginoidea virens is widely distributed in major rice-producing regions. Previous studies have shown that treating RFS with chelerythrine can decrease the germination of fungus spores by 86.7% and induce fungal cell apoptosis. In the present study, the effects of chelerythrine on the metabolism of U.
Wei, Qinghui +8 more
openaire +2 more sources