Results 31 to 40 of about 5,855,365 (255)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

The Open Cluster Chemical Abundances from Spanish Observatories survey (OCCASO) [PDF]

, 2015
We present the motivation, design and current status of the Open Cluster Chemical Abundances from Spanish Observatories survey (OCCASO). Using the high resolution spectroscopic facilities available at Spanish observatories, OCCASO will derive chemical ...
Jordi, C., Martínez-Vázquez, C. E., CARRERA, JIMENEZ RICARDO JESUS, Allende-Prieto, C., PANCINO, ELENA, del Pino, A., Casamiquela, L., Balaguer-Núñez, L., Recio-Blanco, A., Blanco-Cuaresma, S., Murabito, S., Gallart, C., Aparicio, A.   +12 more
core  

The Missing Link of Sulfur Chemistry in TMC-1: The Detection of c-C3H2S from the GOTHAM Survey

The Astrophysical Journal
We present the spectroscopic characterization of cyclopropenethione in the laboratory and detect it in space using the Green Bank Telescope Observations of TMC-1: Hunting Aromatic Molecules survey.
Anthony J. Remijan, P. Bryan Changala, Ci Xue, Elsa Q. H. Yuan, Miya Duffy, Haley N. Scolati, Christopher N. Shingledecker, Thomas H. Speak, Ilsa R. Cooke, Ryan Loomis, Andrew M. Burkhardt, Zachary T. P. Fried, Gabi Wenzel, Andrew Lipnicky, Michael C. McCarthy, Brett A. McGuire   +15 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

A Systematic NLTE Study of Very Metal-poor Stars with Metallicity down to −4.3 dex. VI. Light Neutron-capture Elements and the Sr–Na Correlation as a Signature of Spinstar Nucleosynthesis in the Early Galaxy

The Astrophysical Journal
We present a non–local thermodynamic equilibrium (NLTE) abundance analysis of the light neutron-capture elements Sr, Y, and Zr in a sample of 103 very metal-poor stars spanning −4.3 ≲ [Fe/H] ≲ −1.7, based on high-resolution Subaru/HDS spectra and ...
Sofya Alexeeva, Hongliang Yan, Gang Zhao, Jianrong Shi, Haining Li, Shuai Liu, Zeming Zhou, Junbo Zhang, Jingkun Zhao, Yaqian Wu, Yuqin Chen, Huiling Chen, Huawei Zhang, Wako Aoki   +13 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Chemical abundances determined from meteor spectra: I Ratios of the main chemical elements

, 2003
Relative chemical abundances of 13 meteoroids were determined by averaging the composition of the radiating gas along the fireball path that originated during their penetration into the Earth's atmosphere.
Trigo-Rodriguez, J. M., Llorca, J., Borovicka, J., Fabregat, J.   +3 more
core   +2 more sources

Detailed Chemical Abundance Analysis of the Brightest Stars in the Turranburra and Willka Yaku Stellar Streams

The Astrophysical Journal
We present a detailed chemical abundance analysis of the three brightest known stars from each of the Turranburra and Willka Yaku stellar streams using high-resolution Magellan/Magellan Inamori Kyocera Echelle spectra. Abundances for 27 elements, ranging
K. B. Webber, T. T. Hansen, J. L. Marshall, Alexander P. Ji, Ting S. Li, Gary S. Da Costa, Lara R. Cullinane, Denis Erkal, Sergey E. Koposov, Kyler Kuehn, Geraint F. Lewis, Dougal Mackey, Sarah L. Martell, Andrew B. Pace, Nora Shipp, Jeffrey D. Simpson, Zhen Wan, Daniel B. Zucker, Victor A. Alvarado, Joss Bland-Hawthorn, Guilherme Limberg, Gustavo E. Medina, Sam A. Usman   +22 more
doaj   +1 more source

Evidence for Ubiquitous Carbon Grain Destruction in Hot Protostellar Envelopes

The Astrophysical Journal Letters, 2023
Earth is deficient in carbon and nitrogen by up to ∼4 orders of magnitude compared with the Sun. Destruction of (carbon- and nitrogen-rich) refractory organics in the high-temperature planet-forming regions could explain this deficiency.
Pooneh Nazari, Benoît Tabone, Merel L. R. van ’t Hoff, Jes K. Jørgensen, Ewine F. van Dishoeck   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source