Integration of human cell lines gene expression and chemical properties of drugs for Drug Induced Liver Injury prediction [PDF]
Biology Direct, 2020 Abstract Motivation Drug-induced liver injury (DILI) is one of the primary problems in drug development. Early prediction of DILI can bring a significant reduction in the cost of clinical trials.
Wojciech Lesiński +3 more
openaire +3 more sources
Subnormothermic Perfusion in the Isolated Rat Liver Preserves the Antioxidant Glutathione and Enhances the Function of the Ubiquitin Proteasome System. [PDF]
, 2016 The reduction of oxidative stress is suggested to be one of the main mechanisms to explain the benefits of subnormothermic perfusion against ischemic liver damage. In this study we investigated the early cellular mechanisms induced in isolated rat livers
Alva, Norma +4 more
core +12 more sources
LIVER INJURY INDUCED BY HERBAL AND DIETARY SUPPLEMENTS: A POOLED ANALYSIS OF CASE REPORTS
Arquivos de Gastroenterologia, 2022 Background: The intake of dietary supplements and medicinal plants is very popular worldwide. However, these products are not innocuous, and their intake can cause severe damage to health, especially liver injury. Objective: This study aims to describe
Michelle Hoff de ASSIS +3 more
doaj +1 more source
Frontiers in Genetics, 2022 Drug-Induced Liver Injury (DILI), despite its low occurrence rate, can cause severe side effects or even lead to death. Thus, it is one of the leading causes for terminating the development of new, and restricting the use of already-circulating, drugs.
Nicholas M. Katritsis +11 more
openaire +3 more sources
Food Science and Human Wellness, 2021 Trametes lactinea mycelia polysaccharides (TLMPS) have a wide range of bioactivities. The potential mechanisms of action of TLMPS against acute alcohol-induced liver injury in vivo were investigated by analyzing the physical and chemical properties of ...
Jinbin Hao +5 more
doaj +1 more source
Drug-induced liver injury due to tofacitinib: a case report
Journal of Medical Case Reports, 2023 Background Drug-induced liver injury is an acute or chronic liver damage in response to drugs, herbals, and any chemical compound. Case presentation In the present work, liver failure following the use of tofacitinib was reported.
Masoud Mardani +3 more
doaj +1 more source
The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]
, 2014 BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
A Tostmann +79 more
core +8 more sources
Drug induced liver injury: East versus West – a systematic review and meta-analysis [PDF]
Clinical and Molecular Hepatology, 2020 Drug induced liver injury (DILI) may be different in the East compared to the West due to differing disease prevalence, prescribing patterns and pharmacogenetic profiles.
En Xian Sarah Low +3 more
doaj +1 more source
INFLUENCE OF HIGH-DOSE ATORVASTATIN ON BILE ACID METABOLISM IN MICE WITH LIVER INJURY AND RELATED MECHANISM [PDF]
精准医学杂志, 2023 Objective To investigate the influence of high-dose atorvastatin on bile acid metabolism in mice with liver injury and its mechanism. Methods A total of 40 specific pathogen-free male C57BL/6 mice were randomly divided into normal saline group (group A ...
XIA Feifei, SONG Bingxue, SONG Yuqing, TIAN Jiawei, YAN Hui, HUANG Yuxiao, XIN Hui, LIANG Hui
doaj +1 more source
Hyperin protects against cisplatin-induced liver injury in mice [PDF]
Acta Cirúrgica Brasileira, 2017 Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was ...
Chengwei Niu +4 more
doaj +1 more source