Results 41 to 50 of about 2,835,752 (355)

Carnitine in Alleviation of Complications Caused by Acute Valproic Acid Toxicity; an Exprimental Study on Mice

Archives of Academic Emergency Medicine, 2023
Introduction: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine in mitigating the adverse effects of acute VPA toxicity in mice ...
Akram Jamshidzadeh, Reza Heidari, Mahdie Shams, Melika Ebrahimi-sharghi, Sayed Mahdi Marashi   +4 more
doaj   +1 more source

Assessment of Drug-Induced Liver Injury through Cell Morphology and Gene Expression Analysis

Chemical Research in Toxicology, 2023
Drug-induced liver injury (DILI) is a significant concern in drug development, often leading to drug withdrawal. Although many studies aim to identify biomarkers and gene/pathway signatures related to liver toxicity and aim to predict DILI compounds ...
Vanille Lejal, Natacha Cerisier, D. Rouquié, O. Taboureau   +3 more
semanticscholar   +1 more source

Relevance of Pharmacogenomics to the Safe Use of Antimicrobials

Antibiotics, 2023
There has been widespread implementation of pharmacogenomic testing to inform drug prescribing in medical specialties such as oncology and cardiology. Progress in using pharmacogenomic tests when prescribing antimicrobials has been more limited, though a
Ann K. Daly
doaj   +1 more source

Hepatic safety and possible hepatotoxic action of the metabolites of some pharmaceutical drugs [PDF]

, 2013
Liver is the principle organ for maintaining the body's internal environment. There is currently no way to reimburse for the absence of liver function. Its major influence is on the flow of nutrients and controls the metabolism of carbohydrate, protein ...
Georgieva, Svetlana
core   +2 more sources

Pharmacological correction of hepatotoxicity induced by anti-tuberculosis drugs

Лечащий Врач, 2023
Drug-induced liver injury are one of the most frequent undesirable effects of drug therapy in tuberculosis patients. Hepatoprotective drugs of various origin and chemical composition are used for the correction and prevention of drug-induced liver injury.
D. S. Sukhanov, E. V. Timofeev, Y. S. Alekseeva, K. A. Nagornova   +3 more
doaj   +1 more source

Selective Inhibition of Human Monoamine Oxidase B by Acacetin 7-Methyl Ether Isolated from Turnera diffusa (Damiana) [PDF]

, 2019
© 2019 John Wiley & Sons Ltd Background: Bodybuilding supplements can cause a profound cholestatic syndrome. Aim: To describe the drug-Induced liver injury network\u27s experience with liver injury due to bodybuilding supplements. Methods: Liver injury
Chaurasiya, Narayan D., Doerksen, Robert J., Muhammad, Ilias, Pandey, Pankaj, Tekwani, Babu L., Zhao, Jianping   +5 more
core   +2 more sources

PROSPECTIVE MONITORING OF DRUG USE: DRUG-INDUCED LIVER INJURY IN A PRIMARY HEALTHCARE CENTER [PDF]

Arquivos de Gastroenterologia, 2019
BACKGROUND: Drug-induced liver injury is still misunderstood in Brazil due to diagnostic difficulties or lack of reporting incidents. OBJECTIVE: To assess the frequency of adverse events related to the use of medicines in a primary healthcare unit, in
Nília Maria de Brito Lima PRADO, Gladistone Correia MESSIAS, Genário Oliveira SANTOS JUNIOR, Vinícius Santos NUNES, Maria Isabel SCHINONNI, Raymundo PARANÁ   +5 more
doaj   +1 more source

Acute Hepatitis Associated with Intake of Pistacia Vera L. Bud Tea; a Case Report

Archives of Academic Emergency Medicine, 2023
In this study, a patient who developed acute hepatitis due to drinking Pistacia vera L. bud tea is presented. A twenty-eight-year-old woman who had just come out of the postpartum period applied to our clinic with complaints of nausea, vomiting, loss of
Kazım Ersin Altınsoy, Mehmet Murat Oktay   +1 more
doaj   +1 more source

Dose-related liver injury of Geniposide associated with the alteration in bile acid synthesis and transportation. [PDF]

, 2017
Fructus Gardenia (FG), containing the major active constituent Geniposide, is widely used in China for medicinal purposes. Currently, clinical reports of FG toxicity have not been published, however, animal studies have shown FG or Geniposide can cause ...
Feng, Xiaoyi, Gao, Yue, Han, Jiayin, La Frano, Michael R, Li, Chunying, Li, Guiqin, Li, Xiaolong, Liang, Aihua, Liu, Jing, Newman, John W, Pan, Chen, Tian, Jingzhuo, Wang, Lianmei, Xiang, Shixie, Yi, Yan, Zhang, Yushi, Zhao, Yong, Zhu, Jingjing   +17 more
core   +2 more sources

The incidence of liver injury in Uyghur patients treated for TB in Xinjiang Uyghur autonomous region, China, and its association with hepatic enzyme polymorphisms nat2, cyp2e1, gstm1 and gstt1. [PDF]

, 2014
BACKGROUND AND OBJECTIVE: Of three first-line anti-tuberculosis (anti-TB) drugs, isoniazid is most commonly associated with hepatotoxicity. Differences in INH-induced toxicity have been attributed to genetic variability at several loci, NAT2, CYP2E1 ...
A Tostmann, Atikaimu Wubuli, B Roy, B Roy, C Benichou, Corinne Merle, D Yee, DL Zhu, DS Huang, DW Hein, H Devarbhavi, HG Xie, HJ Cho, HJ De Rosa, HR An, HR An, I Vieira, J Meyer D, JH Wang, Jiayi Gu, Jinfeng Ma, JJ Saukkonen, JN Hirschhorn, JN Pande, JR Mitchell, JR Mitchell, Lei Yang, LG Possuelo, Long Ma, M Dossing, M Guo, M Guo, M Ingelman-Sundberg, M Ohno, M Runge-Morris, Mark Patrick Nicol, Mingqin Cao, N Vuilleumier, Paul Milligan, PD Bose, PD Roy, Qian Wang, Qian Wang, R Shakya, RC Strange, RL Teixeira, S Chatterjee, S Huang Y, S Russmann, S Sunahara, S Yamada, SH Kim, SH Kim, SK Sharma, SW Lee, SW Tang, T Mohri, T Sotsuka, T Wang, T Wang, T Yamamoto, V Leiro, Wei Liu, Weidong Wu, WJ Burman, WM Lee, WW Yew, Xia Zhu, Xiumei Xin, Xuemei Yao, XZ Lv, Y Chen, Yang Xiang, Ying Mao, YM Wu, Yongguang Li, YS Huang, YS Huang, YS Huang, YS Huang   +79 more
core   +7 more sources