Results 41 to 50 of about 74,439 (262)

INFLUENCE OF HIGH-DOSE ATORVASTATIN ON BILE ACID METABOLISM IN MICE WITH LIVER INJURY AND RELATED MECHANISM [PDF]

open access: yes精准医学杂志, 2023
Objective To investigate the influence of high-dose atorvastatin on bile acid metabolism in mice with liver injury and its mechanism. Methods A total of 40 specific pathogen-free male C57BL/6 mice were randomly divided into normal saline group (group A ...
XIA Feifei, SONG Bingxue, SONG Yuqing, TIAN Jiawei, YAN Hui, HUANG Yuxiao, XIN Hui, LIANG Hui
doaj   +1 more source

Hyperin protects against cisplatin-induced liver injury in mice [PDF]

open access: yesActa Cirúrgica Brasileira, 2017
Purpose: To evaluate the effect of hyperin in cisplatin-induced liver injury in mice. Methods: Mice were pretreated with hyperin at doses of 25 mg/kg and 50 mg/kg, respectively, for six days, and intraperitoneal injection of cisplatin (40 mg/kg) was ...
Chengwei Niu   +4 more
doaj   +1 more source

HEPATOPROTECTIVE EFFICACY OF METHANOLIC EXTRACT OF INDIGOFERA SUFFRUTICOSA (MILL) ON PARACETAMOL-INDUCED LIVER DAMAGE IN MICE [PDF]

open access: yesArquivos de Gastroenterologia, 2019
BACKGROUND: Indigofera suffruticosa Mill (Fabaceae) is abundant in northeastern Brazil and popularly used in the treatment of infectious and inflammatory processes.
Izabela Rangel LIMA   +5 more
doaj   +1 more source

Long-term ketamine infusion-induced cholestatic liver injury in COVID-19-associated acute respiratory distress syndrome

open access: yesCritical Care, 2022
Background A higher-than-usual resistance to standard sedation regimens in COVID-19 patients suffering from acute respiratory distress syndrome (ARDS) has led to the frequent use of the second-line anaesthetic agent ketamine. Simultaneously, an increased
Pedro David Wendel-Garcia   +10 more
doaj   +1 more source

Carnitine in Alleviation of Complications Caused by Acute Valproic Acid Toxicity; an Exprimental Study on Mice

open access: yesArchives of Academic Emergency Medicine, 2023
Introduction: Hyperammonemia and hepatotoxicity are well-known complications of valproic acid (VPA) poisoning. The objective of this study is to evaluate the potential role of carnitine in mitigating the adverse effects of acute VPA toxicity in mice ...
Akram Jamshidzadeh   +4 more
doaj   +1 more source

Relevance of Pharmacogenomics to the Safe Use of Antimicrobials

open access: yesAntibiotics, 2023
There has been widespread implementation of pharmacogenomic testing to inform drug prescribing in medical specialties such as oncology and cardiology. Progress in using pharmacogenomic tests when prescribing antimicrobials has been more limited, though a
Ann K. Daly
doaj   +1 more source

Pharmacological correction of hepatotoxicity induced by anti-tuberculosis drugs

open access: yesЛечащий Врач, 2023
Drug-induced liver injury are one of the most frequent undesirable effects of drug therapy in tuberculosis patients. Hepatoprotective drugs of various origin and chemical composition are used for the correction and prevention of drug-induced liver injury.
D. S. Sukhanov   +3 more
doaj   +1 more source

PROSPECTIVE MONITORING OF DRUG USE: DRUG-INDUCED LIVER INJURY IN A PRIMARY HEALTHCARE CENTER [PDF]

open access: yesArquivos de Gastroenterologia, 2019
BACKGROUND: Drug-induced liver injury is still misunderstood in Brazil due to diagnostic difficulties or lack of reporting incidents. OBJECTIVE: To assess the frequency of adverse events related to the use of medicines in a primary healthcare unit, in
Nília Maria de Brito Lima PRADO   +5 more
doaj   +1 more source

Acute Hepatitis Associated with Intake of Pistacia Vera L. Bud Tea; a Case Report

open access: yesArchives of Academic Emergency Medicine, 2023
In this study, a patient who developed acute hepatitis due to drinking Pistacia vera L. bud tea is presented. A twenty-eight-year-old woman who had just come out of the postpartum period applied to our clinic with complaints of nausea, vomiting, loss of
Kazım Ersin Altınsoy   +1 more
doaj   +1 more source

Treatment with gefitinib after erlotinib-induced liver injury: a case report

open access: yesJournal of Medical Case Reports, 2011
Introduction Gefitinib and erlotinib have minor differences in their chemical structures, and thus it remains unclear whether the hepatotoxicity induced by one compound is affected by the other. The case of a patient who developed erlotinib-induced liver
Nakatomi Katsumi   +3 more
doaj   +1 more source

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