Results 41 to 50 of about 76,307 (263)

Does drug-induced liver injury still occur after sevoflurane anesthesia? -A case report- [PDF]

Anesthesia and Pain Medicine
Background Several factors contribute to post-anesthetic hepatic dysfunction, including a decrease in oxygen supply to the liver, direct physical compression of the liver, viral hepatitis, blood transfusions, preexisting hepatic dysfunction, and the use ...
Moon Ok Lee, Seonghyeon Cho, Chaeeun Kim, Hanna Koh   +3 more
doaj   +1 more source

Inhibition of Drug‐Induced Liver Injury in Mice Using a Positively Charged Peptide That Binds DNA

Hepatology Communications, 2021
Hepatic cell death occurs in response to diverse stimuli such as chemical and physical damage. The exposure of intracellular contents such as DNA during necrosis induces a severe inflammatory response that has yet to be fully explored therapeutically ...
Pedro E. Marques, Sofie Vandendriessche, Thiago H.C. deOliveira, Helena Crijns, Mateus E. Lopes, Marfa Blanter, Sara Schuermans, Karen Yu, Fariba Poosti, Vincent Vanheule, Rik Janssens, Daiane Boff, Andreas J. Kungl, Gustavo B. Menezes, Mauro M. Teixeira, Paul Proost   +15 more
doaj   +1 more source

Additional file 5 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 5: Figure S4. Enriched pathways across different feature importance cutoffs for SVM using the DILIrank (−vLessConcern) dataset. Enriched pathways are shown across different feature importance cutoffs which are identified by the percentile of DILI-enriched protein targets covered.
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Towards Decoding Hepatotoxicity of Approved Drugs through Navigation of Multiverse and Consensus Chemical Spaces

Biomolecules, 2023
Drug-induced liver injury (DILI) is the principal reason for failure in developing drug candidates. It is the most common reason to withdraw from the market after a drug has been approved for clinical use.
Edgar López-López, José L. Medina-Franco   +1 more
doaj   +1 more source

Additional file 2 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 2: Figure S1. DILI label prediction performance (balanced accuracy) of RF and SVM models trained using the DILIrank (−vLessConcern) dataset and Mordred molecular descriptors for 5-fold LOCO-CV, external test set, and FDA validation set (Methods).
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

The protective effect and crucial biological pathways analysis of Trametes lactinea mycelium polysaccharides on acute alcoholic liver injury in mice based on transcriptomics and metabonomics

Food Science and Human Wellness, 2021
Trametes lactinea mycelia polysaccharides (TLMPS) have a wide range of bioactivities. The potential mechanisms of action of TLMPS against acute alcohol-induced liver injury in vivo were investigated by analyzing the physical and chemical properties of ...
Jinbin Hao, Liyun Ye, Guoliang Meng, Yanjiao Song, Junsheng Fu, Xiaoping Wu   +5 more
doaj  

Analysis of risk factors of liver injury after intravenous methylprednisolone in neuromyelitis optica spectrum disorders

Chinese Journal of Contemporary Neurology and Neurosurgery, 2022
Objective To investigate the risk factors of liver injury in patients with neuromyelitis optica spectrum disorders (NMOSDs) after intravenous methylprednisolone (IVMP).
YANG Qing⁃lin , LIU Peng⁃peng, WANG Jia⁃wei   +2 more
doaj   +1 more source

Additional file 6 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 6: Table S1. Performance of models trained using the DILIrank (−vLessConcern) dataset. Shown is mean ± standard deviation for 7 metrics (MCC - Matthew’s Correlation Coefficient, PRAUC - Precision-Recall Area Under Curve, ROCAUC - Receiver-Operator-Characteristic Area Under Curve) for models trained using ECFP4, Mordred molecular ...
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Additional file 3 of Prediction and mechanistic analysis of drug-induced liver injury (DILI) based on chemical structure

, 2021
Additional file 3: Figure S2. DILI label prediction performance (balanced accuracy) of RF and SVM models trained using the DILIrank (−vLessConcern) dataset and protein target descriptors for 5-fold LOCO-CV, external test set, and FDA validation set (Methods).
Liu, Anika, Walter, Moritz, Wright, Peter, Bartosik, Aleksandra, Dolciami, Daniela, Elbasir, Abdurrahman, Hongbin Yang, Bender, Andreas   +7 more
openaire   +2 more sources

Pantoprazole-Induced Liver Injury in the Setting of Diabetic Ketoacidosis

Acta Médica Portuguesa
N/a.
Raquel Oliveira, Manuel Almeida, Pedro Lavado, Alexandre Baptista   +3 more
doaj   +1 more source