Results 31 to 40 of about 176,623 (273)

Role of Macrophages in Cytotoxicity, Reactive Oxygen Species Production and DNA Damage in 1,2-Dichloropropane-Exposed Human Cholangiocytes In Vitro

Toxics, 2021
1,2-Dichloropropane (1,2-DCP), a synthetic chlorinated organic compound, was extensively used in the past in offset color proof-printing. In 2014, the International Agency for Research on Cancer (IARC) reclassified 1,2-DCP from its initial Group 3 to ...
Abigail Ekuban, Cai Zong, Frederick Adams Ekuban, Yusuke Kimura, Ryoya Takizawa, Kota Morikawa, Kazuo Kinoshita, Sahoko Ichihara, Seiichiroh Ohsako, Gaku Ichihara   +9 more
doaj   +1 more source

Tauroursodeoxycholic acid dampens oncogenic apoptosis induced by endoplasmic reticulum stress during hepatocarcinogen exposure [PDF]

, 2015
Hepatocellular carcinoma (HCC) is characterized by the accumulation of unfolded proteins in the endoplasmic reticulum (ER), which activates the unfolded protein response (UPR).
Ampe, Christophe, Bogaerts, Eliene, Descamps, Benedicte, Devisscher, Lindsey, Geerts, Anja, Govaere, O, Laukens, Debby, Libbrecht, Louis, Paridaens, Annelies, Raevens, Sarah, Van den Bussche, A, Van Steenkiste, Christophe, Van Troys, Marleen, Van Vlierberghe, Hans, Vandewynckel, Yves-Paul, Vanhove, Christian, Verhelst, Xavier   +16 more
core   +3 more sources

Circ_0025373 inhibits carbon black nanoparticles-induced malignant transformation of human bronchial epithelial cells by affecting DNA damage through binding to MSH2

Environment International
Carbon black nanoparticles (CBNPs) have been demonstrated to induce DNA damage in epithelial cells. However, the potential of the damage to initiate carcinogenesis and the underlying mechanism remain poorly understood.
Han Zhang, Wenfeng Lu, Lan Qiu, Saifeng Li, Liqiu Qiu, Mengnan He, Xintong Chen, Jiajing Wang, Jingwen Fang, Chenghui Zhong, Meiqi Lan, Xiaole Xu, Yun Zhou   +12 more
doaj   +1 more source

Carcinogenicidade do carbendazim e seus metabólitos

Química Nova, 2014
The carcinogenic potential of carbendazim and its metabolites was analyzed using statistical treatment of electronic parameters obtained from DFT/ 6-311++G(d,p) and AM1 calculations.
Renato C. Silva, Karina A. Barros, Antonio C. Pavão   +2 more
doaj   +1 more source

Mathematical methods and models for radiation carcinogenesis studies [PDF]

, 1986
Research on radiation carcinogenesis requires a twofold approach. Studies of primary molecular lesions and subsequent cytogenetic changes are essential, but they cannot at present provide numerical estimates of the risk of small doses of ionizing ...
A.M. Kellerer, Barlow, Bernoulli, Breslow, Broerse, Broerse, Chmelevsky, Chmelevsky, Chmelevsky, Groer, Hoel, Hulse, Kalbfleisch, Kaplan, Kellerer, Lafuma, Mole, National Academy of Sciences, National Research Council, Nelson, Recommendations of the International Commission on Radiological Protection, Rossi, Shellabarger, Shellabarger, Shellabarger, UNSCEAR-Report, Whittemore   +25 more
core   +1 more source

Club cells form lung adenocarcinomas and maintain the alveoli of adult mice

eLife, 2019
Lung cancer and chronic lung diseases impose major disease burdens worldwide and are caused by inhaled noxious agents including tobacco smoke. The cellular origins of environmental-induced lung tumors and of the dysfunctional airway and alveolar ...
Magda Spella, Ioannis Lilis, Mario AA Pepe, Yuanyuan Chen, Maria Armaka, Anne-Sophie Lamort, Dimitra E Zazara, Fani Roumelioti, Malamati Vreka, Nikolaos I Kanellakis, Darcy E Wagner, Anastasios D Giannou, Vasileios Armenis, Kristina AM Arendt, Laura V Klotz, Dimitrios Toumpanakis, Vassiliki Karavana, Spyros G Zakynthinos, Ioanna Giopanou, Antonia Marazioti, Vassilis Aidinis, Rocio Sotillo, Georgios T Stathopoulos   +22 more
doaj   +1 more source

Apc mutation induces resistance of colonic cells to lipoperoxide-triggered apoptosis induced by faecal water from haem-fed rats [PDF]

, 2006
Recent epidemiological studies suggest that high meat intake is associated with promotion of colon cancer linked to haem-iron intake. We previously reported that dietary haem, in the form of either haemoglobin or meat, promotes precancerous lesions in ...
Guéraud, Françoise, Jourdan, Marie-Lise, Petit, Claude, Pierre, Fabrice, Rerole, Anne-Laure, Taché, Sylviane   +5 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

A Case for Caution: An Evaluation of Calabrese and Baldwin\u27s Studies of Chemical Hormesis [PDF]

, 2000
Suggesting a need for more research, Mr. Elliott argues that it is too soon for risk-assessment policy to account for recent challenges to a toxicological linear dose-response ...
Elliott, Kevin C.
core   +2 more sources

Is telomerase reactivation associated with the down-regulatoin of TGFβ receptor-II expression in human breast cancer? [PDF]

, 2003
Background Telomerase is a ribonucleoprotein that synthesizes telomeres and plays an important role in chromosomal stability and cellular immortalisation. Telomerase activity is detectable in most human cancers but not in normal somatic cells. TGF beta (
Elkak, AE, Mokbel, K, Newbold, RF, Thomas, V   +3 more
core   +3 more sources