Results 91 to 100 of about 10,989 (277)

Acanthus ebracteatus leaf extract provides neuronal cell protection against oxidative stress injury induced by glutamate

BMC Complementary and Alternative Medicine, 2018
Background Acanthus ebracteatus (AE), an herb native to Asia, has been recognized in traditional folk medicine not only for its antioxidant properties and various pharmacological activities but also as an ingredient of longevity formulas.
Anchalee Prasansuklab, Tewin Tencomnao
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Grid Computing and Biomolecular Simulation

, 2005
Biomolecular computer simulations are now widely used not only in an academic setting to understand the fundamental role of molecular dynamics on biological function, but also in the industrial context to assist in drug design.

core   +1 more source

Sex-specific impacts of prenatal bisphenol A exposure on genes associated with cortical development, social behaviors, and autism in the offspring’s prefrontal cortex

Biology of Sex Differences
Background Recent studies have shown that prenatal BPA exposure altered the transcriptome profiles of autism-related genes in the offspring’s hippocampus, disrupting hippocampal neuritogenesis and causing male-specific deficits in learning.
Songphon Kanlayaprasit, Thanit Saeliw, Surangrat Thongkorn, Pawinee Panjabud, Kasidit Kasitipradit, Pattanachat Lertpeerapan, Kwanjira Songsritaya, Wasana Yuwattana, Thanawin Jantheang, Depicha Jindatip, Valerie W. Hu, Takako Kikkawa, Noriko Osumi, Tewarit Sarachana   +13 more
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

Information extraction and linked open data in chemistry

, 2016
Chemists not only produce a significant amount of data-rich scholarly communication artifacts, but have also adopted a highly formulaic style of writing. The literature of this discipline is an attractive target for automated data extraction. In previous
Adams, Nico, Downing, Jim, Murray-Rust, Peter, Hawizy, Lezan   +3 more
core  

The Diversity of CYP2C19 Polymorphisms in the Thai Population: Implications for Precision Medicine

The Application of Clinical Genetics
Vorthunju Nakhonsri,1 Shobana John,2,3 Hathaichanok Panumasmontol,4,5 Manassanan Jantorn,4,5 Pongpipat Chanthot,4,5 Nuntachai Hanpramukkun,6 Supaporn Meelarp,7 Chonlaphat Sukasem,2,3 Sissades Tongsima,1 Sukhontha Hasatsri,4 Abhisit Prawang,8 Thanawat ...
Nakhonsri V, John S, Panumasmontol H, Jantorn M, Chanthot P, Hanpramukkun N, Meelarp S, Sukasem C, Tongsima S, Hasatsri S, Prawang A, Thaingtamtanha T, Vanwong N, Atasilp C, Chamnanphon M, Jinda P, Satapornpong P   +16 more
doaj  

LC-MS Analysis and Evaluation of Antioxidant and Antibacterial Activities of Royle from Nepal: An / Approach

Natural Product Communications
Background: Falconeria insignis Royle, a medicinal plant of the Euphorbiaceae family, has been extensively used in Nepal for bacteria-infected wounds, despite the lack of empirical evidence supporting its efficacy. Objectives: This study aims to evaluate
Ram Kishor Yadav, Sushil Panta, Sindhu KC, Prabhat Kumar Jha, Sandesh Poudel, Siddha Raj Upadhyaya, Kushal Subedi, Susmita Baral, Rekha Bhandari, Bipindra Pandey   +9 more
doaj   +1 more source

Biophysical approaches for studying viral entry

FEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Obituary − Emeritus Professor Dr John Davidson McCraw (1925−2014) MBE, MSc NZ, DSc Well, CRSNZ, FNZSSS.

, 2015
John McCraw was an Earth scientist who began working as a pedologist with Soil Bureau, DSIR, then became the Foundation Professor of Earth Sciences at the University of Waikato in Hamilton, inspiring a new generation to study and work in Earth sciences .
Nelson, Campbell S., Lowe, David J., Tonkin, Philip J.   +2 more
core