Results 111 to 120 of about 10,989 (277)

Prenatal exposure to bisphenol A disrupts RNA splicing in the prefrontal cortex and promotes behaviors related to autism in offspring

Scientific Reports
Prenatal exposure to bisphenol A (BPA), a common endocrine disruptor, has been increasingly implicated in neurodevelopmental disorders, including autism spectrum disorder.
Pawinee Panjabud, Songphon Kanlayaprasit, Surangrat Thongkorn, Kwanjira Songsritaya, Pattanachat Lertpeerapan, Kasidit Kasitipradit, Thanawin Jantheang, Suthathip Sarobol, Thanit Saeliw, Valerie W. Hu, Takeshi Imai, Tewarit Sarachana   +11 more
doaj   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Kaempferia parviflora Extracellular Vesicle Loaded with Clarithromycin for the Treatment of Helicobacter pylori Infection

International Journal of Nanomedicine
Variya Nemidkanam,1 Wijit Banlunara,2 Nuntaree Chaichanawongsaroj3 1Department of Clinical Chemistry, Graduate Program in Clinical Biochemistry and Molecular Medicine, Faculty of Allied Health Sciences, Chulalongkorn University, Bangkok, 10330, Thailand;
Nemidkanam V, Banlunara W, Chaichanawongsaroj N   +2 more
doaj  

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Conferences 2

, 2014
ConferencesChemrawn XII - African food security and natural resource management: the new scientific frontiers20-24 June, 1999, KenyaAn international conference to foster stakeholder input to advance the role of chemistry and allied sciences in..
Technical Centre for Agricultural and Rural Cooperation
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Two-Dimensional Magnesium Phosphate Nanosheets Promote Antibacterial Effects and Wound Closure

International Journal of Nanomedicine
Salma Younes,1,2 Salma MS Ahmad,1 Pannawich Thirabowonkitphithan,3,4 Shaden H Abunasser,1 Nouran Zein,1 Amir Elhadad,5 Asada Leelahavanichkul,6– 8 Wanida Laiwattanapaisal,9,10 Awni Al-Otoom,11 Khaled A Mahmoud,12 Faleh Tamimi,5 Gheyath K Nasrallah1,2 ...
Younes S, Ahmad SMS, Thirabowonkitphithan P, Abunasser SH, Zein N, Elhadad A, Leelahavanichkul A, Laiwattanapaisal W, Al-Otoom A, Mahmoud KA, Tamimi F, Nasrallah GK   +11 more
doaj  

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

MS

, 2007
thesisA protocol is presented for adopting clinical chemistry methods in the service laboratory. The protocol may be used to adopt alternate procedures to those currently in use and for the adoption of new methods not previously performed by the service
Nielsen, Leonard Gary
core